Muscle-derived but not centrally derived transgene GDNF is neuroprotective in G93A-SOD1 mouse model of ALS.

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

journal_title：Experimental neurology

authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

更新日期：2015-05-01 00:00:00

abstract：:Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a hi...

journal_title：Experimental neurology

authors： Sattler R,Ayukawa Y,Coddington L,Sawa A,Block D,Chipkin R,Rothstein JD

更新日期：2011-12-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:The role of type IIA receptor protein tyrosine phosphatases (RPTPs), which includes LAR, RPTPσ and RPTPδ, in the nervous system is becoming increasingly recognized. Evidence supports a significant role for these RPTPs during the development of the nervous system as well as after injury, and mutations in RPTPs are asso...

journal_title：Experimental neurology

authors： Yi JH,Katagiri Y,Yu P,Lourie J,Bangayan NJ,Symes AJ,Geller HM

更新日期：2014-05-01 00:00:00

abstract：:Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...

journal_title：Experimental neurology

authors： Kawamata T,Ren J,Cha JH,Finklestein SP

更新日期：1999-07-01 00:00:00

abstract：:Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...

journal_title：Experimental neurology

authors： Fukuda H,Wada JA,Riche D,Naquet R

更新日期：1987-10-01 00:00:00

abstract：:Posttraumatic stress disorder (PTSD), chronic psychological stress, and major depressive disorder have been found to be associated with a significant decrease in glial fibrillary acidic protein (GFAP) immunoreactivity in the hippocampus of rodents. Cotinine is an alkaloid that prevents memory impairment, depressive-li...

journal_title：Experimental neurology

authors： Perez-Urrutia N,Mendoza C,Alvarez-Ricartes N,Oliveros-Matus P,Echeverria F,Grizzell JA,Barreto GE,Iarkov A,Echeverria V

更新日期：2017-09-01 00:00:00

abstract：:The longitudinal distributions of both phrenic and medial gastrocnemius motoneurons were quantitatively studied in the cat spinal cord. Both populations of motoneurons were retrogradely labeled by applying horseradish peroxidase (HRP) to the cut central ends of the appropriate peripheral nerves. The longitudinal posit...

journal_title：Experimental neurology

authors： Berger AJ,Cameron WE,Averill DB,Kramis RC,Binder MD

更新日期：1984-12-01 00:00:00

abstract：:The effect of corporal hypothermia on regional blood flow in peripheral nerve is unknown. We compared blood flow in resting sciatic nerves of anesthetized, normothermic rats with that of rats whose rectal temperatures had been acutely lowered to 28 to 30 degrees C. Peripheral nerve regional blood flow in normothermic ...

journal_title：Experimental neurology

authors： Sugimoto H,Monafo WW,Shimazaki S

更新日期：1987-08-01 00:00:00

abstract：:Both alpha- and beta-adrenergic receptors (ARs) are involved in the facilitation of the monosynaptic jaw-closing reflex in the trigeminal motor nucleus (MoV) caused by norepinephrine (NE). The amplitude of muscle spindle afferent-evoked EPSPs in masseter motor neurons is 65% greater when noradrenergic axons to the mot...

journal_title：Experimental neurology

authors： Shao YP,Sutin J

更新日期：1991-11-01 00:00:00

abstract：:This study uses the saphenous nerve crush model in Thy1-YFP mice and serial transcutaneous imaging to evaluate the rate of nerve regeneration under various FK-506 (tacrolimus) dosing regimens and in the presence of transgenic overexpression of glial cell line-derived neurotrophic factor (GDNF). Thy1-YFP transgenic mic...

journal_title：Experimental neurology

authors： Yan Y,Sun HH,Mackinnon SE,Johnson PJ

更新日期：2011-11-01 00:00:00

abstract：:Dopamine (DA) affects GABA neuronal function in the striatum and together these neurotransmitters play a large role in locomotor function. We recently reported that unilateral striatal administration of GDNF, a growth factor that has neurotrophic effects on DA neurons and enhances DA release, bilaterally increased str...

journal_title：Experimental neurology

authors： Salvatore MF,Gerhardt GA,Dayton RD,Klein RL,Stanford JA

更新日期：2009-09-01 00:00:00

abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....

journal_title：Experimental neurology

authors： Soja PJ,Finch DM,Chase MH

更新日期：1987-04-01 00:00:00

abstract：:This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral exte...

journal_title：Experimental neurology

authors： Biran V,Joly LM,Héron A,Vernet A,Véga C,Mariani J,Renolleau S,Charriaut-Marlangue C

更新日期：2006-05-01 00:00:00

abstract：:Although prior studies have implicated maladaptive remodeling of dendritic spines on wide-dynamic range dorsal horn neurons as a contributor to pain after spinal cord injury, there have been no studies on dendritic spines after peripheral nerve injury. To determine whether dendritic spine remodeling contributes to neu...

journal_title：Experimental neurology

authors： Tan AM,Chang YW,Zhao P,Hains BC,Waxman SG

更新日期：2011-12-01 00:00:00

abstract：:NMDA receptors in postmortem human spinal cord were analyzed using [3H]MK-801 ligand binding and immunoblotting with NMDA receptor subunit-specific antibodies. The average KD for [3H]MK-801 binding was 1.77 nM with a Bmax of 0.103 pmol/mg. The EC50 for stimulation of -3H-MK-801 binding with L-glutamate was 0.34 microM...

journal_title：Experimental neurology

authors： Sundström E,Whittemore S,Mo LL,Seiger A

更新日期：1997-12-01 00:00:00

abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

journal_title：Experimental neurology

authors： Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

更新日期：2004-09-01 00:00:00

abstract：:The role of capsaicin-sensitive afferents in neurogenic voiding dysfunction was studied in chronic spinal cord injured rats (SCI). Cystometry and external urethral sphincter (EUS) electromyography were performed on 2 consecutive days after induction of urethane anesthesia in SCI rats 6-8 weeks after spinal cord injury...

journal_title：Experimental neurology

authors： Cheng CL,de Groat WC

更新日期：2004-06-01 00:00:00

abstract：:We have investigated the formation of DNA adducts and oxidative base damage produced by copper sulfate activation of dopamine and 6-hydroxydopamine. In the presence of 10 microM copper sulfate both 100 microM dopamine and 100 microM 6-hydroxydopamine formed three similar DNA adducts with relative adduct levels of 8.36...

journal_title：Experimental neurology

authors： Lévay G,Ye Q,Bodell WJ

更新日期：1997-08-01 00:00:00

abstract：:Pretreatment with the synthetic glucocorticoid dexamethasone prevents hypoxic-ischemic brain damage in 7-day-old neonatal rats. We presently characterize the response further by examining the effect of varying the age, the glucocorticoid, and the time of injection and by examining whether fasting can influence the res...

journal_title：Experimental neurology

authors： Tuor UI,Chumas PD,Del Bigio MR

更新日期：1995-03-01 00:00:00

abstract：:The amount of myelination in vivo and in vitro depends on the number of oligodendrocyte progenitors, their differentiation, and on the neuron function. It has been shown that continuous administration of FGF2, a mitotic and neuroprotective factor, allows oligodendrocyte progenitors to proliferate, but prevents them fr...

journal_title：Experimental neurology

authors： Magy L,Keita M,Richard L,Piaser M,Vallat JM

更新日期：2003-05-01 00:00:00

abstract：:GABAergic dysfunction is implicated in hippocampal deficits of the Ts65Dn mouse model of Down syndrome (DS). Since Ts65Dn mice overexpress G-protein coupled inward-rectifying potassium (GIRK2) containing channels, we sought to evaluate whether increased GABAergic function disrupts the functioning of hippocampal circui...

journal_title：Experimental neurology

authors： Best TK,Cramer NP,Chakrabarti L,Haydar TF,Galdzicki Z

更新日期：2012-02-01 00:00:00

abstract：:Most neurons in the dorsal neostriatum die 1 day after 30 min of cerebral ischemia. Dopamine may play a role in the pathogenesis of neuronal injury in neostriatum following ischemia. It has been shown that the number of surviving neurons in the right neostriatum dramatically increased following ischemia after lesions ...

journal_title：Experimental neurology

authors： Xu ZC,Chwang W,Li X,Chen X,He P

更新日期：1999-07-01 00:00:00

abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

journal_title：Experimental neurology

authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

更新日期：2008-01-01 00:00:00

abstract：:We previously showed that overexpressing the 70-kDa inducible heat shock protein in primary astrocyte cultures and in a rodent stroke model using viral vectors resulted in protection from ischemia and ischemia-like injury. However, viral transfection could potentially provoke a stress response itself; therefore, we ex...

journal_title：Experimental neurology

authors： Lee JE,Yenari MA,Sun GH,Xu L,Emond MR,Cheng D,Steinberg GK,Giffard RG

更新日期：2001-07-01 00:00:00

abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...

journal_title：Experimental neurology

authors： Brook GA,Spitzer C,Nacimiento W,Kouchtir-Devanne N,Woodhams PL,Noth J

更新日期：1997-07-01 00:00:00

abstract：:It is widely accepted that the immune system plays important functional roles in regeneration after injury to the spinal cord. Immune response towards injury involves a complex interplay of immune system cells, such as neutrophils, macrophages and microglia, T- and B-lymphocytes. We investigated the influence of the l...

journal_title：Experimental neurology

authors： Wu B,Matic D,Djogo N,Szpotowicz E,Schachner M,Jakovcevski I

更新日期：2012-10-01 00:00:00

abstract：:Our previous study demonstrates that delayed (initiated 24h post injury) erythropoietin (EPO) therapy for traumatic brain injury (TBI) significantly improves spatial learning. In this study, we investigated the impact of inhibition of EPO treatment-mediated neurogenesis on spatial learning after experimental TBI. Youn...

journal_title：Experimental neurology

authors： Zhang Y,Chopp M,Mahmood A,Meng Y,Qu C,Xiong Y

更新日期：2012-05-01 00:00:00

abstract：:The binding of agonists and antagonists to beta-adrenergic receptors in brain tissue obtained postmortem in nonalcoholic controls and matched intoxicated and sober alcoholics was measured to assess the state of the receptors and their coupling to adenylate cyclase. Binding of antagonist, iodocyanopindolol, to cerebral...

journal_title：Experimental neurology

authors： Valverius P,Borg S,Valverius MR,Hoffman PL,Tabakoff B

更新日期：1989-09-01 00:00:00