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Glial activation in white matter following ischemia in the neonatal P7 rat brain.

Abstract：

:This study examines cell death and proliferation in the white matter after neonatal stroke. In postnatal day 7 injured rat, there was a marked reduction in myelin basic protein (MBP) immunostaining mainly corresponding to numerous pyknotic immature oligodendrocytes and TUNEL-positive astrocytes in the ipsilateral external capsule. In contrast, a substantial restoration of MBP, as indicated by the MBP ratio of left-to-right, occurred in the cingulum at 48 (1.27 +/- 0.12) and 72 (1.30 +/- 0.18, P < 0.05) h of recovery as compared to age-matched controls (1.03 +/- 0.14). Ki-67 immunostaining revealed a first peak of newly generated cells in the dorsolateral hippocampal subventricular zone and cingulum at 72 h after reperfusion. Double immunofluorescence revealed that most of the Ki-67-positive cells were astrocytes at 48 h and NG2 pre-oligodendrocytes at 72 h of recovery. Microglia infiltration occurs over several days in the cingulum, and a huge quantity of macrophages reached the subcortical white matter where they engulfed immature oligodendrocytes. The overall results suggest that the persistent activation of microglia involves a chronic component of immunoinflammation, which overwhelms repair processes and contributes to cystic growth in the developing brain.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Biran V,Joly LM,Héron A,Vernet A,Véga C,Mariani J,Renolleau S,Charriaut-Marlangue C

doi

10.1016/j.expneurol.2006.01.037

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

103-12

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(06)00202-0

journal_volume

199

pub_type

杂志文章

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