Abstract：
:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep. The amplitude of the reflex during these states was determined before and after strychnine, picrotoxin, and bicuculline methiodide were applied, by microinjection, to the trigeminal motor nucleus. The effectiveness of each drug in blocking the active sleep-related suppression of the masseteric reflex was examined and compared with the degree of suppression evoked, during wakefulness, by stimulation of the inferior alveolar nerve. Microinjection of strychnine (50 microM to 20 mM) reduced the degree of suppression of the masseteric reflex during active sleep, but was markedly more effective in blocking reflex suppression that was induced by stimulating the inferior alveolar nerve. Picrotoxin and bicuculline methiodide (10 microM to 5 mM) produced a nonspecific increase in the amplitude of the masseteric reflex during both states. Thus, these substances did not appear to reduce the degree of reflex suppression induced by inferior alveolar nerve stimulation or that occurring spontaneously during active sleep. We concluded that strychnine-sensitive postsynaptic inhibition does participate in the suppression of masseter motor activity during active sleep, but that it is not the exclusive factor responsible for atonia of the masseter musculature during this state.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Soja PJ,Finch DM,Chase MHdoi
10.1016/0014-4886(87)90179-8subject
Has Abstractpub_date
1987-04-01 00:00:00pages
178-93issue
1eissn
0014-4886issn
1090-2430journal_volume
96pub_type
杂志文章abstract：:The ability of striatal embryonic grafts to promote functional recovery on complex behavioral tasks depends on various factors, including the amount of striatal-like tissue within the grafts and the duration of post-graft training. However, how the innate paw bias of animals is affected by experience, or influences re...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.12.033
更新日期：2006-06-01 00:00:00
abstract：:Three-day-old rats received an infusion of a small dose of 6-hydroxydopamine (6-OHDA) (12 micrograms) directly into the locus ceruleus nuclei, in order to induce a subtotal lesion of the noradrenergic system. Significant modifications in cerebellum maturation were observed, mainly a regression failure in the perisomat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90120-7
更新日期：1985-04-01 00:00:00
abstract：:Human recombinant activated factor-VII (rFVIIa) has been used successfully in the treatment of spontaneous intracerebral hemorrhage. In addition, there is increasing interest in its use to treat uncontrolled bleeding of other origins, including trauma. The aim of this study was to evaluate the safety and potential eff...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.12.019
更新日期：2008-04-01 00:00:00
abstract：:One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.12.013
更新日期：2009-04-01 00:00:00
abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.07.022
更新日期：2017-01-01 00:00:00
abstract：:Embryonic substantia nigra grafts partially reinnervate the dopamine-denervated corpus striatum when implanted adjacent to that structure. This reinnervation is generally limited to a small portion of the denervated striatum and does not completely compensate for the behavioral effects of a 6-hydroxydopamine lesion of...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90151-8
更新日期：1987-02-01 00:00:00
abstract：:Traumatic axonal injury (TAI) evolves within minutes to hours following traumatic brain injury (TBI). Previous studies have identified axolemmal disruption and impaired axonal transport (AxT) as key mechanisms in the evolution of TAI. While initially hypothesized that axolemmal disruption culminates in impaired AxT, p...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.022
更新日期：2004-11-01 00:00:00
abstract：:Poor survival of embryonic dopamine neurons is a primary problem limiting the value of neurotransplantation for Parkinson's disease. Several neurotrophic factors have been shown to promote dopamine neuron survival when used individually in culture. We have found that two peptides, insulin-like growth factor-I (IGF-I) ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1996.0115
更新日期：1996-07-01 00:00:00
abstract：:Temporomandibular disorders (TMDs) are orofacial pains within the trigeminal distribution, which involve the masticatory musculature, the temporomandibular joint or both. Their pathophysiology remains unclear, as inflammatory mediators are thought to be involved, and clinically TMD presents pain and sometimes limitati...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.05.005
更新日期：2015-09-01 00:00:00
abstract：:This study was undertaken as part of the NIH "Facilities of Research-Spinal Cord Injury" project to support independent replication of published studies. Here, we repeated a study reporting that a combinatorial treatment with transplants of Schwann cells, systemic delivery of Rolipram to enhance cyclic AMP levels, and...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.12.020
更新日期：2012-02-01 00:00:00
abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2019.113071
更新日期：2020-01-01 00:00:00
abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.08.001
更新日期：2012-11-01 00:00:00
abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113386
更新日期：2020-10-01 00:00:00
abstract：:One of the major histopathological hallmarks of Alzheimer's disease (AD) is redundant senile plaques mainly composed of beta-amyloid (Abeta) aggregates. Alternative cleavage of the amyloid precursor protein (APP), occurring in both normal and AD subjects, results in the generation and secretion of soluble APP (sAPP) a...
journal_title：Experimental neurology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/s0014-4886(03)00027-x
更新日期：2003-09-01 00:00:00
abstract：:This article reviews stem cell-based strategies for spinal cord injury repair, and practical issues concerning their translation to the clinic. Recent progress in the stem cell field includes clinically compliant culture conditions and directed differentiation of both embryonic stem cells and somatic stem cells. We pr...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2007.09.002
更新日期：2008-02-01 00:00:00
abstract：:While past neuroimaging methods have contributed greatly to our understanding of brain function after traumatic brain injury (TBI), resting state functional MRI (rsfMRI) connectivity methods have more recently provided a far more unbiased approach with which to monitor brain circuitry compared to task-based approaches...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.12.020
更新日期：2016-03-01 00:00:00
abstract：:Fibroblast and epidermal growth factors (FGF-2 and EGF) are powerful mitogens for neural precursor cells isolated from the developing striatum and grown as neurospheres. However, questions remain as to the exact role of each of these molecules, and how the proteoglycan heparin may modify their behavior. Here, we show ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.05.007
更新日期：2004-08-01 00:00:00
abstract：:Mammals adopt a limited number of postures during their day-to-day activities. These stereotyped skeletal configurations are functionally adequate and limit the number of degrees of freedom to be controlled by the central nervous system. The temporal pattern of emergence of these configurations in altricial mammals is...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.05.018
更新日期：2006-11-01 00:00:00
abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7926
更新日期：2002-07-01 00:00:00
abstract：:After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.08.020
更新日期：2005-12-01 00:00:00
abstract：:In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90029-r
更新日期：1990-11-01 00:00:00
abstract：:Microfilaments (MFs) play an important role in wound healing and other regenerative events. The purpose of this study was to characterize changes in the distribution of MFs in traumatized auditory epithelia and compare these changes between avian (regenerating) and mammalian (nonregenerating) ears. Chicks and guinea p...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(92)90217-e
更新日期：1992-01-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.01.013
更新日期：2011-04-01 00:00:00
abstract：:Second-order neurons in trigeminal subnucleus caudalis (Vc) and upper cervical spinal cord (C1) are critical for craniofacial pain processing and project rostrally to terminate in: ventral posteromedial thalamic nucleus (VPM), medial thalamic nuclei (MTN) and parabrachial nuclei (PBN). The contribution of each region ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2017.03.024
更新日期：2017-07-01 00:00:00
abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7218
更新日期：1999-12-01 00:00:00
abstract：:Infection with human immunodeficiency virus-1 (HIV-1) is associated with dysfunctions of the central nervous system (CNS). HIV-1 induces its effects on the CNS by a variety of mechanisms, including by shedding the neurotoxic viral proteins such as gp120 and Tat. Both HIV-1 and gp120 have been shown to cross the blood-...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.11.019
更新日期：2005-05-01 00:00:00
abstract：:In cats anesthetized with nitrous oxide and halothane, ion-selecting microelectrodes were used to monitor changes in the concentration of potassium [K+]0 and calcium [Ca2+]0 in the extracellular compartment of the cerebral cortex during as long as 4 h of continuous stimulation of the cortical surface. At stimulus char...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90220-0
更新日期：1983-02-01 00:00:00
abstract：:The purpose of this study was to assess the respiratory and tonic activity of the abdominal muscles and the postinspiratory activity of the diaphragm (stage 1 expiration) in rats during sleep while they breathed air, hypercapnic, and hypoxic gas mixtures. ECoG and neck EMG recordings enabled the differentiation to be ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90064-7
更新日期：1988-07-01 00:00:00
abstract：:C2 spinal cord hemisection results in synaptic and astroglial changes in the phrenic nucleus which have been associated with the recovery of the ipsilateral hemidiaphragm during expression of the crossed phrenic phenomenon. As part of our ongoing analysis of the neurotransmitters involved, the present study investigat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7238
更新日期：1999-12-01 00:00:00
abstract：:Electrical stimulation of the midbrain tegmentum can produce differential modulation of quiet biting attack and affective defense behavior elicited from the hypothalamus of the cat. Stimulation of the lateral half of the tegmentum facilitated quiet biting attack and suppressed affective defense. Conversely, stimulatio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(84)90112-2
更新日期：1984-02-01 00:00:00
