Nerve growth factor receptors in the central nervous system.


:Nerve growth factor (NGF) is well known to be involved in the development, survival, and maintenance of sympathetic and neural crest-derived sensory neurons in the peripheral nervous system. Over the last 10-15 years, however, the role of NGF as a necessary trophic substrate for magnocellular cholinergic neurons in the central nervous system (CNS) has emerged. Because the trophic effects of NGF are initiated by its interaction with membrane-bound receptors, the characterization, localization, and function of these specific NGF receptors are essential to understanding the many actions of NGF. The first part of this review will summarize briefly the presence and possible role of NGF in the CNS, with the remainder of the review focusing on what is known about the receptor to NGF.


Exp Neurol


Experimental neurology


Springer JE




Has Abstract


1988-12-01 00:00:00












  • Plasma alpha-synuclein is decreased in subjects with Parkinson's disease.

    abstract::Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

    更新日期:2007-04-01 00:00:00

  • Beta-adrenergic receptor binding in brain of alcoholics.

    abstract::The binding of agonists and antagonists to beta-adrenergic receptors in brain tissue obtained postmortem in nonalcoholic controls and matched intoxicated and sober alcoholics was measured to assess the state of the receptors and their coupling to adenylate cyclase. Binding of antagonist, iodocyanopindolol, to cerebral...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Valverius P,Borg S,Valverius MR,Hoffman PL,Tabakoff B

    更新日期:1989-09-01 00:00:00

  • Defeating the fear: new insights into the neurobiology of stress susceptibility.

    abstract::The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Krishnan V

    更新日期:2014-11-01 00:00:00

  • Focal and dose-dependent neuroprotection in ALS mice following AAV2-neurturin delivery.

    abstract::Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patients. Previous studies in Parkinson's Disease (PD) models have shown pro...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Gross SK,Shim BS,Bartus RT,Deaver D,McEachin Z,Bétourné A,Boulis NM,Maragakis NJ

    更新日期:2020-01-01 00:00:00

  • Role of lipocalin-2 in extracellular peroxiredoxin 2-induced brain swelling, inflammation and neuronal death.

    abstract::Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

    更新日期:2021-01-01 00:00:00

  • Sympathetic projections to the epithalamus.

    abstract::Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Patrickson JW,Smith TE

    更新日期:1987-08-01 00:00:00

  • Role of the corpus callosum and hippocampal commissure on transfer phenomenon in amygdala-kindled cats.

    abstract::Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Fukuda H,Wada JA,Riche D,Naquet R

    更新日期:1987-10-01 00:00:00

  • Discharge from total populations of Ia and II afferent fibers in the cat's deefferented medial gastrocnemius muscle during static stretch.

    abstract::Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Botterman BR,Eldred E

    更新日期:1983-04-01 00:00:00

  • Anti-CD40 ligand monoclonal antibody induces a permissive state, but not tolerance, for murine peripheral nerve allografts.

    abstract::Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Brenner MJ,Tung TH,Mackinnon SE,Myckatyn TM,Hunter DA,Mohanakumar T

    更新日期:2004-03-01 00:00:00

  • Three to four-year-old nonpassaged EGF-responsive neural progenitor cells: proliferation, apoptosis, and DNA repair.

    abstract::Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Zhou FC,Kelley MR,Chiang YH,Young P

    更新日期:2000-07-01 00:00:00

  • Increased alpha-synuclein aggregation following limited cleavage by certain matrix metalloproteinases.

    abstract::Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

    更新日期:2009-01-01 00:00:00

  • Successful storage of peripheral nerve before transplantation using green tea polyphenol: an experimental study in rats.

    abstract::Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

    更新日期:2003-12-01 00:00:00

  • Nuclear magnetic resonance response of protons in normal and pathological human muscles.

    abstract::An in vitro study of the nuclear magnetic resonance (NMR) response of protons in normal and pathological human skeletal muscle is presented. Muscle biopsies from 34 patients with various neuromuscular diseases and five normal subjects were studied by proton NMR techniques and the results were compared with those of li...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Borghi L,Savoldi F,Scelsi R,Villa M

    更新日期:1983-07-01 00:00:00

  • Heparin ameliorates cerebral edema and improves outcomes following status epilepticus by protecting endothelial glycocalyx in mice.

    abstract::Blood brain barrier (BBB) hyperpermeability and brain edema contribute to increased seizure susceptibility and brain injury in status epilepticus (SE). The endothelial glycocalyx is the coating on luminal side of the endothelium and can be considered as the first barrier of BBB. Currently, little is known about the ef...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Li X,Zhu J,Liu K,Hu Y,Huang K,Pan S

    更新日期:2020-08-01 00:00:00

  • A novel closed-body model of spinal cord injury caused by high-pressure air blasts produces extensive axonal injury and motor impairments.

    abstract::Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive w...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG

    更新日期:2015-09-01 00:00:00

  • Human nasal olfactory epithelium as a dynamic marker for CNS therapy development.

    abstract::Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a hi...

    journal_title:Experimental neurology

    pub_type: 临床试验,杂志文章


    authors: Sattler R,Ayukawa Y,Coddington L,Sawa A,Block D,Chipkin R,Rothstein JD

    更新日期:2011-12-01 00:00:00

  • The effect of hemorrhage on the development of the postnatal mouse cerebellum.

    abstract::Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Yoo JY,Mak GK,Goldowitz D

    更新日期:2014-02-01 00:00:00

  • Regulation of semaphorin III/collapsin-1 gene expression during peripheral nerve regeneration.

    abstract::The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Pasterkamp RJ,Giger RJ,Verhaagen J

    更新日期:1998-10-01 00:00:00

  • Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation.

    abstract::Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Lemons ML,Howland DR,Anderson DK

    更新日期:1999-11-01 00:00:00

  • Effect of fluoxetine on HIF-1α- Netrin/VEGF cascade, angiogenesis and neuroprotection in a rat model of transient middle cerebral artery occlusion.

    abstract::Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

    更新日期:2020-07-01 00:00:00

  • FAS deficiency reduces apoptosis, spares axons and improves function after spinal cord injury.

    abstract::After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Casha S,Yu WR,Fehlings MG

    更新日期:2005-12-01 00:00:00

  • Tanycytes present in the adult rat mediobasal hypothalamus support the regeneration of monoaminergic axons.

    abstract::We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Chauvet N,Prieto M,Alonso G

    更新日期:1998-05-01 00:00:00

  • Astrocyte-derived fatty acid-binding protein 7 protects blood-brain barrier integrity through a caveolin-1/MMP signaling pathway following traumatic brain injury.

    abstract::The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

    更新日期:2019-12-01 00:00:00

  • Transplantation of mesencephalic cell suspension in dopamine-denervated striatum of the rat.I. Effects on spontaneous activity of striatal neurons.

    abstract::These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Di Loreto S,Florio T,Capozzo A,Napolitano A,Adorno D,Scarnati E

    更新日期:1996-04-01 00:00:00

  • Sleep deprivation attenuates experimental stroke severity in rats.

    abstract::Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

    更新日期:2010-03-01 00:00:00

  • Effect of repeated versus single electroconvulsive seizures on adrenergic-mediated phosphatidylinositol hydrolysis in rat neocortex.

    abstract::Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Dubeau F,Sherwin AL

    更新日期:1989-08-01 00:00:00

  • Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat.

    abstract::Axonal lesions to the optic nerve (ON) induce c-Jun expression in retinal ganglion cells (RGCs) of the rat in vivo. Detailed investigations using retrograde tracers, and double labeling studies for c-Jun and regeneration-associated factors, such as the growth-associated protein GAP-43, have suggested that this upregul...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Isenmann S,Bähr M

    更新日期:1997-09-01 00:00:00

  • Restitution of functional neural connections in chick embryos assessed in vitro after spinal cord transection in Ovo.

    abstract::Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Sholomenko GN,Delaney KR

    更新日期:1998-12-01 00:00:00

  • Vasoactive intestinal peptide antagonist treatment during mouse embryogenesis impairs social behavior and cognitive function of adult male offspring.

    abstract::Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

    journal_title:Experimental neurology

    pub_type: 杂志文章


    authors: Hill JM,Cuasay K,Abebe DT

    更新日期:2007-07-01 00:00:00

  • Modeling the complex pathology of Alzheimer's disease in Drosophila.

    abstract::Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审


    authors: Fernandez-Funez P,de Mena L,Rincon-Limas DE

    更新日期:2015-12-01 00:00:00