Nerve growth factor receptors in the central nervous system.

abstract：:Alpha-synuclein (alphaSN) is implicated in Parkinson's disease (PD) and is the major component of Lewy bodies (LBs). Although alphaSN is mainly expressed in neuronal cells and exists as a cytoplasmic protein, it has been found in body fluids including cerebrospinal fluid and blood. This study explored plasma alphaSN a...

journal_title：Experimental neurology

authors： Li QX,Mok SS,Laughton KM,McLean CA,Cappai R,Masters CL,Culvenor JG,Horne MK

更新日期：2007-04-01 00:00:00

abstract：:The binding of agonists and antagonists to beta-adrenergic receptors in brain tissue obtained postmortem in nonalcoholic controls and matched intoxicated and sober alcoholics was measured to assess the state of the receptors and their coupling to adenylate cyclase. Binding of antagonist, iodocyanopindolol, to cerebral...

journal_title：Experimental neurology

authors： Valverius P,Borg S,Valverius MR,Hoffman PL,Tabakoff B

更新日期：1989-09-01 00:00:00

abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

journal_title：Experimental neurology

authors： Krishnan V

更新日期：2014-11-01 00:00:00

abstract：:Neurotrophic factors as candidates for ALS therapeutics have previously been studied in the context of attempts to slow disease progression. For a variety of reasons, clinical trials of neurotrophic factors have failed to show efficacy in ALS patients. Previous studies in Parkinson's Disease (PD) models have shown pro...

journal_title：Experimental neurology

authors： Gross SK,Shim BS,Bartus RT,Deaver D,McEachin Z,Bétourné A,Boulis NM,Maragakis NJ

更新日期：2020-01-01 00:00:00

abstract：:Peroxiredoxin-2 (PRX-2) is known to be released from erythrocytes and induce brain damage after intracerebral hemorrhage (ICH); lipocalin-2 (LCN-2) is involved in neuroinflammation following ICH. This study examined the role of LCN-2 in PRX-2 induced brain injury and involved three parts. In the first part, adult male...

journal_title：Experimental neurology

authors： Zhang J,Novakovic N,Hua Y,Keep RF,Xi G

更新日期：2021-01-01 00:00:00

abstract：:Injections of horseradish peroxidase were made into surgically exposed superior cervical ganglia of Sprague-Dawley rats weighing 250 to 320 g. Anterogradely labeled postganglionic fibers were observed in the nervus conarii, pineal gland, pineal stalk, and the choroid plexus. Terminal fields were identified in lamina i...

journal_title：Experimental neurology

authors： Patrickson JW,Smith TE

更新日期：1987-08-01 00:00:00

abstract：:Forebrain-bisected cats underwent kindling at primary and secondary amygdala sites. The behavioral effect of amygdala kindling was then examined according to the extent of the surgical lesion in the forebrain commissures. Bisection of the corpus callosum with or without lesion of the hippocampal commissure modified bo...

journal_title：Experimental neurology

authors： Fukuda H,Wada JA,Riche D,Naquet R

更新日期：1987-10-01 00:00:00

abstract：:Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...

journal_title：Experimental neurology

authors： Botterman BR,Eldred E

更新日期：1983-04-01 00:00:00

abstract：:Anti-CD40 ligand monoclonal antibody prevents the interaction between CD40 and its T-cell-based ligand, thereby resulting in selective inhibition of T cell costimulation without pan-T-cell suppression. This antibody has found application in several animal models of solid organ transplantation. This study investigated ...

journal_title：Experimental neurology

authors： Brenner MJ,Tung TH,Mackinnon SE,Myckatyn TM,Hunter DA,Mohanakumar T

更新日期：2004-03-01 00:00:00

abstract：:Epidermal growth factor responsive (EGFr) neural progenitor (NP) cells have been shown to be a potential alternative tissue source for neural transplantation and for developmental study. We have shown that nonpassaged EGFr NP cells can self-renew for 2 years in neurospheres and can robustly differentiate into glia and...

journal_title：Experimental neurology

authors： Zhou FC,Kelley MR,Chiang YH,Young P

更新日期：2000-07-01 00:00:00

abstract：:Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

journal_title：Experimental neurology

authors： Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

更新日期：2009-01-01 00:00:00

abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

journal_title：Experimental neurology

authors： Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

更新日期：2003-12-01 00:00:00

abstract：:An in vitro study of the nuclear magnetic resonance (NMR) response of protons in normal and pathological human skeletal muscle is presented. Muscle biopsies from 34 patients with various neuromuscular diseases and five normal subjects were studied by proton NMR techniques and the results were compared with those of li...

journal_title：Experimental neurology

authors： Borghi L,Savoldi F,Scelsi R,Villa M

更新日期：1983-07-01 00:00:00

abstract：:Blood brain barrier (BBB) hyperpermeability and brain edema contribute to increased seizure susceptibility and brain injury in status epilepticus (SE). The endothelial glycocalyx is the coating on luminal side of the endothelium and can be considered as the first barrier of BBB. Currently, little is known about the ef...

journal_title：Experimental neurology

authors： Li X,Zhu J,Liu K,Hu Y,Huang K,Pan S

更新日期：2020-08-01 00:00:00

abstract：:Diffuse axonal injury is thought to be the basis of the functional impairments stemming from mild traumatic brain injury. To examine how axons are damaged by traumatic events, such as motor vehicle accidents, falls, sports activities, or explosive blasts, we have taken advantage of the spinal cord with its extensive w...

journal_title：Experimental neurology

authors： del Mar N,von Buttlar X,Yu AS,Guley NH,Reiner A,Honig MG

更新日期：2015-09-01 00:00:00

abstract：:Discovery of new central nervous system (CNS) acting therapeutics has been slowed down by the lack of useful applicable biomarkers of disease or drug action often due to inaccessibility of relevant human CNS tissue and cell types. In recent years, non-neuronal cells, such as astrocytes, have been reported to play a hi...

journal_title：Experimental neurology

authors： Sattler R,Ayukawa Y,Coddington L,Sawa A,Block D,Chipkin R,Rothstein JD

更新日期：2011-12-01 00:00:00

abstract：:Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...

journal_title：Experimental neurology

authors： Yoo JY,Mak GK,Goldowitz D

更新日期：2014-02-01 00:00:00

abstract：:The competence of neurons to regenerate depends on their ability to initiate a program of gene expression supporting growth and on the growth-permissive properties of glial cells in the distal stump of the injured nerve. Most studies on intrinsic molecular mechanisms governing peripheral nerve regeneration have focuss...

journal_title：Experimental neurology

authors： Pasterkamp RJ,Giger RJ,Verhaagen J

更新日期：1998-10-01 00:00:00

abstract：:Extrinsic factors appear to contribute to the lack of regeneration in the injured adult spinal cord. It is likely that these extrinsic factors include a group of putative growth inhibitory molecules known as chondroitin sulfate proteoglycans (CSPGs). The aims of this study were to determine: (1) the consequences of sp...

journal_title：Experimental neurology

authors： Lemons ML,Howland DR,Anderson DK

更新日期：1999-11-01 00:00:00

abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

journal_title：Experimental neurology

authors： Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:After spinal cord injury (SCI), apoptosis of neurons and oligodendrocytes is associated with axonal degeneration and loss of neurological function. Recent data have suggested a potential role for FAS death receptor-mediated apoptosis in the pathophysiology of SCI. In this study, we examined the effect of FAS deficienc...

journal_title：Experimental neurology

authors： Casha S,Yu WR,Fehlings MG

更新日期：2005-12-01 00:00:00

abstract：:We have recently shown that tanycytes present in the median eminence (ME) constitute a preferential support for the regeneration of lesioned neurohypophysial oxytocinergic and vasopressinergic axons. However, although tanycytes are particularly abundant in the ME, they are also present along the third ventricle wall. ...

journal_title：Experimental neurology

authors： Chauvet N,Prieto M,Alonso G

更新日期：1998-05-01 00:00:00

abstract：:The astrocyte-endothelial cell interaction is crucial for normal brain homeostasis and blood-brain barrier (BBB) disruption in pathological conditions. However, the mechanism by which astrocytes control BBB integrity, especially after traumatic brain injury (TBI), remains unclear. Here, we present evidence that astroc...

journal_title：Experimental neurology

authors： Rui Q,Ni H,Lin X,Zhu X,Li D,Liu H,Chen G

更新日期：2019-12-01 00:00:00

abstract：:These studies have examined the extent to which intrastriatal grafts of embryonic mesencephalic neurons induce recovery of normal discharge patterns in striatal neurons of rats after a unilateral 6-hydroxydopamine (6-OHDA) lesion of the nigrostriatal dopamine (DA) pathway. Lesioned rats were tested for rotational beha...

journal_title：Experimental neurology

authors： Di Loreto S,Florio T,Capozzo A,Napolitano A,Adorno D,Scarnati E

更新日期：1996-04-01 00:00:00

abstract：:Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

journal_title：Experimental neurology

authors： Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

更新日期：2010-03-01 00:00:00

abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

journal_title：Experimental neurology

authors： Dubeau F,Sherwin AL

更新日期：1989-08-01 00:00:00

abstract：:Axonal lesions to the optic nerve (ON) induce c-Jun expression in retinal ganglion cells (RGCs) of the rat in vivo. Detailed investigations using retrograde tracers, and double labeling studies for c-Jun and regeneration-associated factors, such as the growth-associated protein GAP-43, have suggested that this upregul...

journal_title：Experimental neurology

authors： Isenmann S,Bähr M

更新日期：1997-09-01 00:00:00

abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

journal_title：Experimental neurology

authors： Sholomenko GN,Delaney KR

更新日期：1998-12-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

journal_title：Experimental neurology

authors： Hill JM,Cuasay K,Abebe DT

更新日期：2007-07-01 00:00:00

abstract：:Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...

journal_title：Experimental neurology

authors： Fernandez-Funez P,de Mena L,Rincon-Limas DE

更新日期：2015-12-01 00:00:00