Abstract：
:Parameters related to the capacity and the rate of uptake of calcium ions by the sarcoplasmic reticulum were measured in skinned extensor digitorum longus fibers of control and myodystrophic mice. Single fibers were isolated and skinned in a relaxing solution and mounted on a force transducer and apparatus for changing the bathing solution (T = 25 degrees C). To test the capacity of the sarcoplasmic reticulum, fibers were placed in a solution for maximal loading and then moved to a test solution in which the major anion in the relaxing solution, gluconate, was replaced by chloride. In the resulting contractures, the means of the forces produced by 10 control and myodystrophic fibers were not significantly different. The conclusion is that the capacities of sarcoplasmic reticulum for calcium in control and myodystrophic fibers are equivalent. To test the rate of loading of sarcoplasmic reticulum, 11 control and myodystrophic fibers were depleted of calcium with caffeine and EGTA. Then they were placed in a solution with pCa = 5.5, and the delay before a contracture began was recorded. The delay was the time required for the sarcoplasmic reticulum to load calcium and attain a threshold for calcium-induced calcium release. The mean delay for the control fibers was significantly less than the mean delay in myodystrophic for the control fibers was significantly less than the mean delay in myodystrophic fibers. The disparity of loading times probably reflected a difference in the activities of the calcium pumps or a difference in the number of pump sites; 5 microM valinomycin did not significantly alter the loading times of either type or fiber.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Mobley BAdoi
10.1016/0014-4886(85)90140-2subject
Has Abstractpub_date
1985-01-01 00:00:00pages
137-46issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(85)90140-2journal_volume
87pub_type
杂志文章abstract：:This study uses the saphenous nerve crush model in Thy1-YFP mice and serial transcutaneous imaging to evaluate the rate of nerve regeneration under various FK-506 (tacrolimus) dosing regimens and in the presence of transgenic overexpression of glial cell line-derived neurotrophic factor (GDNF). Thy1-YFP transgenic mic...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2011.06.013
更新日期：2011-11-01 00:00:00
abstract：:Osteopontin (OPN) is a glycosylated phosphoprotein that regulates both oxidative stress and inflammatory processes. OPN is present in the rat substantia nigra (SN) and both protein and mRNA levels are up-regulated following a pro-inflammatory insult produced by lipopolysaccharide. We now report on the effects of lesio...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.05.030
更新日期：2007-09-01 00:00:00
abstract：:Following a unilateral fimbria-fornix lesion, the delivery of nerve growth factor (NGF) to the ipsilateral lateral ventricle of the rat can prevent the lesion-induced loss of choline acetyltransferase (ChAT) expression in the ipsilateral medial septum and vertical diagonal band region. In the present study, the abilit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(90)90049-x
更新日期：1990-10-01 00:00:00
abstract：:Spinal cord injury (SCI) is a tragic event causing irreversible losses of sensory, motor, and autonomic functions, that may also be associated with chronic neuropathic pain. Serotonin (5-HT) neurotransmission in the spinal cord is critical for modulating sensory, motor, and autonomic functions. Following SCI, 5-HT axo...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2019.05.007
更新日期：2019-08-01 00:00:00
abstract：:Long-term levodopa or dopamine agonist treatment in the MPTP-lesioned primate model of Parkinson's disease elicits dyskinesia, which is phenotypically similar to levodopa-induced dyskinesia in patients with Parkinson's disease. AMPA receptor antagonists have previously been shown to have both anti-parkinsonian and ant...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7854
更新日期：2002-03-01 00:00:00
abstract：:Fibroblast Growth Factors (FGFs) and their receptors (FGFRs) are widely expressed in the mature nervous system and are thought to mediate plasticity and repair. We report the generation of transgenic mice that can be induced to express a dominant-negative FGFR (dnFGFR) in select neuronal populations. We show that a mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2005.12.020
更新日期：2006-04-01 00:00:00
abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...
journal_title：Experimental neurology
pub_type： 临床试验,杂志文章
doi：10.1016/j.expneurol.2011.10.013
更新日期：2012-01-01 00:00:00
abstract：:The electromyographic (EMG) activity of the gastrocnemius and tibialis anterior muscles was recorded from normal geriatric subjects and from hemiplegic patients subjected to a continuous back-and-forth movement of the platform on which they stood. The platform oscillated at a fixed frequency of 0.5 Hz. Movement amplit...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(88)90156-2
更新日期：1988-02-01 00:00:00
abstract：:Multiple system atrophy (MSA) is a rare neurodegenerative disease of undetermined cause manifesting with progressive autonomic failure (AF), cerebellar ataxia and parkinsonism due to neuronal loss in multiple brain areas associated with (oligodendro)glial cytoplasmic alpha-synuclein (alpha SYN) inclusions (GCIs). Usin...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.05.008
更新日期：2010-08-01 00:00:00
abstract：:Neonatal hypoxia ischemia (HI) is the main cause of newborn mortality and morbidity. Preclinical studies have shown that the immature rat brain is more resilient to HI injury, suggesting innate mechanisms of neuroprotection. During neonatal period brain metabolism experience changes that might greatly affect the outco...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2020.113317
更新日期：2020-08-01 00:00:00
abstract：:While acute spinal cord injury has been the object of intensive research, chronic spinal cord injury has received less attention although most clinical cases of spinal cord injury become chronic. We attempted to surgically "repair" chronic and acute spinal cord injury in a complete transection rat model using a multip...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2004.01.032
更新日期：2004-07-01 00:00:00
abstract：:The effects of prenatal exposure to carbon monoxide (CO), a major component of cigarette smoke, was studied alone or in combination with postnatal hyperthermia, on the structural and neurochemical development of the postnatal brain at 1 and 8 weeks. Pregnant guinea pigs (n = 11) were exposed to 200 p.p.m CO for 10 h/d...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7272
更新日期：2000-04-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for nigrostriatal dopaminergic, central cholinergic, and motoneurons. GDNF also prevents the neuronal loss in experimental animal models for Parkinson's disease (PD). We have now investigated the GDNF gene for possible mutations in a group ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6857
更新日期：1998-08-01 00:00:00
abstract：:Our results indicate that Long-Evans male rats housed in standard conditions show no significant difference between the areas of sections of their left and right amygdalas. In contrast, the S1 strain maze-bright animals have a significantly greater right amygdala than left. Furthermore, the data indicate an overall in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90187-0
更新日期：1984-11-01 00:00:00
abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(84)90148-1
更新日期：1984-08-01 00:00:00
abstract：:Rat axial muscle previously has not been studied histochemically. We were interested in determining the fiber composition and fiber distribution in rat lateral longissimus (LL), the large epaxial dorsiflexor muscle active during sexual posturing in the female rat and to determine if estrogen replacement in ovariectomi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90229-7
更新日期：1983-02-01 00:00:00
abstract：:Wistar rats (n = 58) were injected subcutaneously during the lactation period with fluoxetine (5, 10, 20 or 40 mg/kg/day) and cortical spreading depression (SD) was recorded immediately after weaning (25-30 days of life). An additional group (10 mg/kg; n = 8) was SD-recorded at 60-70 days. As compared to the saline-in...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.02.014
更新日期：2006-08-01 00:00:00
abstract：:The gastrointestinal tract of vertebrates is a heterogeneous organ system innervated to varying degrees by a local enteric neural network as well as extrinsic parasympathetic and sympathetic neural circuits located along the brainstem and spinal axis. This diverse organ system serves to regulate the secretory and prop...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2019.113009
更新日期：2019-10-01 00:00:00
abstract：:The transformation of a cut axonal end into a growth cone (GC), after axotomy, is a critical event in the cascade leading to regeneration. In an earlier series of studies we analyzed the cellular cascades that transform a cut axonal end into a competent GC. We found that axotomy of cultured Aplysia neurons leads to a ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2009.05.004
更新日期：2009-09-01 00:00:00
abstract：:A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendroc...
journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2016.02.023
更新日期：2016-09-01 00:00:00
abstract：:Glial cell line-derived neurotrophic factor (GDNF) is a potent survival factor for motoneurons (MNs), and is considered a potential agent for the treatment of amyotrophic lateral sclerosis (ALS) and other MN diseases. The effectiveness of GDNF may depend significantly upon its route of delivery to MNs. In this study w...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.08.028
更新日期：2007-02-01 00:00:00
abstract：:Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(87)90261-5
更新日期：1987-12-01 00:00:00
abstract：:The contribution of chondroitin sulfate proteoglycan (CSPG) in the suppression of axonal growth in rat spinal cord has been examined by means of an in vitro bioassay in which regenerating neurons are grown on tissue section substrata. Dissociated embryonic chick dorsal root ganglionic neurons were grown on normal and ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6951
更新日期：1998-12-01 00:00:00
abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1995.1025
更新日期：1995-06-01 00:00:00
abstract：:Numerous epidemiological studies have shown an association between pesticide exposure and an increased risk of developing Parkinson's disease (PD). Here, we provide evidence that the insecticide dieldrin causes specific oxidative damage in the nigrostriatal dopamine (DA) system. We report that exposure of mice to low ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.12.020
更新日期：2007-04-01 00:00:00
abstract：:Fifteen male mice (C57/Bl6J) were fed the liquid diet "Stardit" supplemented with vitamins together with phenytoin for 8 weeks; experimental animals and controls were pair-fed. After 8 weeks of treatment, the anesthetized animals were perfused with 3.5% glutaraldehyde. Tissue samples of the cerebral cortex (area 3), c...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(86)90026-9
更新日期：1986-01-01 00:00:00
abstract：:Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be inv...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2012.11.011
更新日期：2013-02-01 00:00:00
abstract：:C2 spinal cord hemisection results in synaptic and astroglial changes in the phrenic nucleus which have been associated with the recovery of the ipsilateral hemidiaphragm during expression of the crossed phrenic phenomenon. As part of our ongoing analysis of the neurotransmitters involved, the present study investigat...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7238
更新日期：1999-12-01 00:00:00
abstract：:This paper reports that endolymphatic hydrops causes a significant reduction of retrogradely labeled cell bodies of the ipsilateral trigeminal ganglion following application of horseradish peroxidase in the cochlea. We previously showed that the trigeminal ganglion is a source of primary sensory innervation to the coc...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6813
更新日期：1998-06-01 00:00:00
abstract：:A comparison of regenerated and normal frog sciatic nerves showed a marked reduction in conduction velocity from 37.5 to 15.2 m/s with little change in the absolute refractory period. Changes in conduction velocity corresponded to a reduced mean axon caliber (4.8 versus 6.6 micron). Regenerated nerves also had markedl...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90141-4
更新日期：1985-01-01 00:00:00
