Expression of c-Jun protein in degenerating retinal ganglion cells after optic nerve lesion in the rat.

abstract：:A "neuroplastic" hypothesis proposes that changes in neuronal structural plasticity may underlie the aetiology of depression and the action of antidepressants. The medial prefrontal cortex (mPFC) is affected by this disorder and shows an intense expression of the polysialylated form of the neural cell adhesion molecul...

journal_title：Experimental neurology

authors： Castillo-Gómez E,Gómez-Climent MA,Varea E,Guirado R,Blasco-Ibáñez JM,Crespo C,Martínez-Guijarro FJ,Nácher J

更新日期：2008-11-01 00:00:00

abstract：:Injury of a peripheral nerve not only leads to target denervation, but also induces massive stripping of spinal synapses on axotomized motoneurons, with disruption of spinal circuits. Even when regeneration is successful, unspecific reinnervation and the limited reconnection of the spinal circuits impair functional re...

journal_title：Experimental neurology

authors： Arbat-Plana A,Torres-Espín A,Navarro X,Udina E

更新日期：2015-01-01 00:00:00

abstract：:Cortical spreading depression (CSD) is associated with various short- and long-term physiological and neurochemical changes and has been shown to confer an increased susceptibility to accompanying ischemic injury or provide protection against a subsequent experimental ischemia. Nitric oxide is involved in the processe...

journal_title：Experimental neurology

authors： Shen PJ,Gundlach AL

更新日期：1999-12-01 00:00:00

abstract：:Calcium-independent nitric oxide synthase (NOS) activity has been reported in ischemic brains and usually attributed to the inducible isoform, iNOS. Because calcium-independent mechanisms have recently been shown to regulate the constitutive calcium-dependent NOS, we proposed to confirm the presence of iNOS activity i...

journal_title：Experimental neurology

authors： Lerouet D,Jafarian-Tehrani M,Louin G,Palmier B,Bonnefont-Rousselot D,Plotkine M,Margaill I

更新日期：2005-09-01 00:00:00

abstract：:Reactive synaptogenesis and terminal proliferation are known to occur in the dentate gyrus of the rat hippocampus following removal of specific afferents. In the present study we have examined the relation of synaptophysin immunoreactivity to the immunohistochemical staining pattern of GAP-43, a putative marker of neu...

journal_title：Experimental neurology

authors： Masliah E,Fagan AM,Terry RD,DeTeresa R,Mallory M,Gage FH

更新日期：1991-08-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

journal_title：Experimental neurology

authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

更新日期：2014-01-01 00:00:00

abstract：:One approach to repair of transected nerves is to attempt extrinsic guidance of axons across the gaps. We inserted the proximal and distal stumps of severed mouse sciatic nerves into opposite ends of biodegradable polyester tubes. The nerves and ensheathing tubes were examined after postoperative survival times of as ...

journal_title：Experimental neurology

authors： Henry EW,Chiu TH,Nyilas E,Brushart TM,Dikkes P,Sidman RL

更新日期：1985-12-01 00:00:00

abstract：:The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. D...

journal_title：Experimental neurology

authors： Andreassen OA,Dedeoglu A,Friedlich A,Ferrante KL,Hughes D,Szabo C,Beal MF

更新日期：2001-04-01 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) is an adult-onset, fatal neurodegenerative syndrome characterized by the systemic loss of motor neurons with prominent astrocytosis and microgliosis in the spinal cord and brain. Astrocytes play an essential role in maintaining extracellular microenvironments that surround motor neu...

journal_title：Experimental neurology

authors： Shijo T,Warita H,Suzuki N,Ikeda K,Mitsuzawa S,Akiyama T,Ono H,Nishiyama A,Izumi R,Kitajima Y,Aoki M

更新日期：2018-09-01 00:00:00

abstract：:In monkeys, unilateral intracarotid infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces a useful model of hemiparkinsonism. To evaluate MPTP-induced neurochemical changes in vivo, brain microdialysis was employed to measure extracellular levels of dopamine and its metabolites in the neostriatum of...

journal_title：Experimental neurology

authors： Skirboll S,Wang J,Mefford I,Hsiao J,Bankiewicz KS

更新日期：1990-11-01 00:00:00

abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

journal_title：Experimental neurology

authors： Xie L,Zhao H,Wang Y,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:NMDA receptors in postmortem human spinal cord were analyzed using [3H]MK-801 ligand binding and immunoblotting with NMDA receptor subunit-specific antibodies. The average KD for [3H]MK-801 binding was 1.77 nM with a Bmax of 0.103 pmol/mg. The EC50 for stimulation of -3H-MK-801 binding with L-glutamate was 0.34 microM...

journal_title：Experimental neurology

authors： Sundström E,Whittemore S,Mo LL,Seiger A

更新日期：1997-12-01 00:00:00

abstract：:Urotensin-II (U-II) is a cyclic peptide identified recently in many mammalian species including man. U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues. Although this peptide has been reported initially to be a potent vasoconstrictor, increas...

journal_title：Experimental neurology

authors： Chuquet J,Lecrux C,Chatenet D,Leprince J,Chazalviel L,Roussel S,MacKenzie ET,Vaudry H,Touzani O

更新日期：2008-04-01 00:00:00

abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...

journal_title：Experimental neurology

authors： Hendrickson RC,Raskind MA

更新日期：2016-10-01 00:00:00

abstract：:Hamsters were inoculated intracerebrally with the agent of transmissible mink encephalopathy and developed clerical signs of encephalopathy. Photoreceptor degeneration occurred in all animals examined histologically. The changes were similar to those in scrapie, although less extensive. The findings suggest that eithe...

journal_title：Experimental neurology

authors： Buyukmihci NC,Goehring-Harmon F,Marsh RF

更新日期：1987-06-01 00:00:00

abstract：:We have investigated the long-term effects of 15-16 min or 19-20 min of perinatal asphyxia on D1, D2, and D3 receptors (analyzed by quantitative autoradiography) in the mesotelencephalic dopamine systems of the 4-week-old rat. Perinatal asphyxia reduced D1 antagonist binding ([3H]SCH 23390 in the presence of ketanseri...

journal_title：Experimental neurology

authors： Chen Y,Hillefors-Berglund M,Herrera-Marschitz M,Bjelke B,Gross J,Andersson K,von Euler G

更新日期：1997-07-01 00:00:00

abstract：:A transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with mutant huntingtin transgenes. In a n...

journal_title：Experimental neurology

authors： Petersén A,Chase K,Puschban Z,DiFiglia M,Brundin P,Aronin N

更新日期：2002-05-01 00:00:00

abstract：:Osteogenic protein-1 (OP-1), a member of the transforming growth factor-beta (TGF-beta) superfamily, has been demonstrated to stimulate dendrite growth from sympathetic neurons in culture. However, it is not known whether OP-1 affects dendrite growth from central nervous system neurons. Therefore we quantified axon an...

journal_title：Experimental neurology

authors： Le Roux P,Behar S,Higgins D,Charette M

更新日期：1999-11-01 00:00:00

abstract：:The focus of this study is the expression of Toll-like receptor-3 (TLR-3), a receptor for double-stranded RNA, in human brains affected by Alzheimer's disease (AD) pathology. Toll-like receptors are a family of pattern recognition molecules primarily involved in host defenses to microbial pathogens, but roles in neuro...

journal_title：Experimental neurology

authors： Walker DG,Tang TM,Lue LF

更新日期：2018-11-01 00:00:00

abstract：:Globoid cell leukodystrophy (GLD, Krabbe Disease) is a lysosomal storage disease, resulting from the genetic deficiency of galactosylceramidase (GALC). This disease is marked by accumulation of the cytotoxic lipid psychosine (Psy). Psychosine is known to induce oxidative stress in cultured cells, and this stress can b...

journal_title：Experimental neurology

authors： Hawkins-Salsbury JA,Qin EY,Reddy AS,Vogler CA,Sands MS

更新日期：2012-10-01 00:00:00

abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

journal_title：Experimental neurology

authors： Greco T,Vespa PM,Prins ML

更新日期：2020-07-01 00:00:00

abstract：:In order to test the functional implication of herpes simplex virus (HSV) vector-mediated gene transfer after axonal injury, we injected replication-incompetent HSV vectors coding for the anti-apoptotic peptide Bcl-2 and the glial cell-derived neurotrophic factor (GDNF), separately or in combination into ventral spina...

journal_title：Experimental neurology

authors： Natsume A,Wolfe D,Hu J,Huang S,Puskovic V,Glorioso JC,Fink DJ,Mata M

更新日期：2003-12-01 00:00:00

abstract：:Six patients with long-lasting spasticity resistant to different drug therapies including oral baclofen received a bolus injection of lumbar intrathecal baclofen. Electromyographic (EMG) reactions of leg muscles (soleus, tibialis anterior, quadriceps, and hamstrings) to standard stimuli and during attempts at voluntar...

journal_title：Experimental neurology

authors： Latash ML,Penn RD,Corcos DM,Gottlieb GL

更新日期：1989-02-01 00:00:00

abstract：:Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this context, the main objective of the present study was to better understand ...

journal_title：Experimental neurology

authors： Veinbergs I,Van Uden E,Mallory M,Alford M,McGiffert C,DeTeresa R,Orlando R,Masliah E

更新日期：2001-07-01 00:00:00

abstract：:Exogenous myelin- or axolemma-enriched fractions were assessed for the ability to inhibit biochemical and morphological expressions of reactive gliosis in rat optic nerve. Elvax pellets containing exogenous myelin, axolemma, whole-brain homogenate, liver, or red cell extracts or no homogenate were inserted into a dura...

journal_title：Experimental neurology

authors： Politis MJ

更新日期：1988-05-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:Traumatic axonal injury (TAI) evolves within minutes to hours following traumatic brain injury (TBI). Previous studies have identified axolemmal disruption and impaired axonal transport (AxT) as key mechanisms in the evolution of TAI. While initially hypothesized that axolemmal disruption culminates in impaired AxT, p...

journal_title：Experimental neurology

authors： Stone JR,Okonkwo DO,Dialo AO,Rubin DG,Mutlu LK,Povlishock JT,Helm GA

更新日期：2004-11-01 00:00:00