Hippocampal synaptic depression following spatial learning in a complex maze.

abstract：:The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

journal_title：Experimental neurology

authors： Cruz CD,McMahon SB,Cruz F

更新日期：2006-07-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:Increased vascular permeability causing vasogenic brain edema is characteristic for many acute neurological diseases such as stroke, brain trauma, and meningitis. Src family kinases, especially c-Src, play an important role in regulating blood-brain barrier permeability in response to VEGF, but also mediate leukocyte ...

journal_title：Experimental neurology

authors： Paul R,Angele B,Popp B,Klein M,Riedel E,Pfister HW,Koedel U

更新日期：2007-01-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Functional neural reconnection is not common after spinal cord transection in the CNS of adult higher vertebrates but has been demonstrated in embryonic avian and neonatal mammalian CNS. Chick brainstem spinal cord preparations from nontransected controls and embryos transected at the cervical level on embryonic days ...

journal_title：Experimental neurology

authors： Sholomenko GN,Delaney KR

更新日期：1998-12-01 00:00:00

abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...

journal_title：Experimental neurology

authors： Sabelström H,Stenudd M,Frisén J

更新日期：2014-10-01 00:00:00

abstract：:Chondroitin sulfate proteoglycans (CSPGs) are extracellular matrix (ECM) molecules that are widely expressed throughout the developing and adult CNS. In vitro studies demonstrate their potential to restrict neurite outgrowth, and it is believed that CSPGs also inhibit axonal regeneration after CNS injury in vivo. Prev...

journal_title：Experimental neurology

authors： Jones LL,Margolis RU,Tuszynski MH

更新日期：2003-08-01 00:00:00

abstract：:Peripheral neuropathy (PN) is a debilitating and dose-limiting side effect of treatment with the chemotherapeutic agent, paclitaxel. Understanding the effects of paclitaxel on sensory neuronal function and the signaling pathways which mediate these paclitaxel-induced changes in function are critical for the developmen...

journal_title：Experimental neurology

authors： Pittman SK,Gracias NG,Vasko MR,Fehrenbacher JC

更新日期：2014-03-01 00:00:00

abstract：:Total, Mg2+-, Na+,K+-, and Ca2+-ATPase activities were studied in fresh brain membrane preparations from adult epileptic (El) mice and nonepileptic C57BL/6J (B6) mice. The El mice have an inherited type of temporal lobe epilepsy. No significant differences were observed between the El and B6 mice for any of the ATPase...

journal_title：Experimental neurology

authors： Palayoor ST,Seyfried TN

更新日期：1988-03-01 00:00:00

abstract：:Cortical stimulation (CS) as a means to modulate regional activity and excitability in cortex is emerging as a promising approach for facilitating rehabilitative interventions after brain damage, including stroke. In this study, we investigated whether CS-induced functional improvements are linked with synaptic plasti...

journal_title：Experimental neurology

authors： Adkins DL,Hsu JE,Jones TA

更新日期：2008-07-01 00:00:00

abstract：:Children who are born preterm are at risk for encephalopathy of prematurity, a leading cause of cerebral palsy, cognitive delay and behavioral disorders. Current interventions are limited and none have been shown to reverse cognitive and behavioral impairments, a primary determinant of poor quality of life for these c...

journal_title：Experimental neurology

authors： Robinson S,Corbett CJ,Winer JL,Chan LAS,Maxwell JR,Anstine CV,Yellowhair TR,Andrews NA,Yang Y,Sillerud LO,Jantzie LL

更新日期：2018-04-01 00:00:00

abstract：:Fifteen male mice (C57/Bl6J) were fed the liquid diet "Stardit" supplemented with vitamins together with phenytoin for 8 weeks; experimental animals and controls were pair-fed. After 8 weeks of treatment, the anesthetized animals were perfused with 3.5% glutaraldehyde. Tissue samples of the cerebral cortex (area 3), c...

journal_title：Experimental neurology

authors： Volk B,Kirchgässner N,Detmar M

更新日期：1986-01-01 00:00:00

abstract：:In this study we evaluate the expression of all members of the class 3 semaphorins and their receptor components following complete transection and contusion lesions of the adult rat spinal cord. Following both types of lesions the expression of all class 3 semaphorins is induced in fibroblast in the neural scar. The ...

journal_title：Experimental neurology

authors： De Winter F,Oudega M,Lankhorst AJ,Hamers FP,Blits B,Ruitenberg MJ,Pasterkamp RJ,Gispen WH,Verhaagen J

更新日期：2002-05-01 00:00:00

abstract：:Traumatic brain injury (TBI) in animals and man generates widespread axonal injury characterized by focal axolemmal permeability changes, induction of calpain-mediated proteolysis, and neurofilament side-arm modification associated with neurofilament compaction (NFC) evolving to axonal disconnection. Recent observatio...

journal_title：Experimental neurology

authors： Büki A,Koizumi H,Povlishock JT

更新日期：1999-09-01 00:00:00

abstract：:The Fmr1 knockout (KO) mouse is characterized by an increased audiogenic seizure (AGS) susceptibility and is considered a good animal model for epilepsy and seizures in the human fragile-X (FRAX) syndrome. Here, we tested the hypothesis that the reintroduction of the FMR1 gene is able to revert the AGS susceptibility ...

journal_title：Experimental neurology

authors： Musumeci SA,Calabrese G,Bonaccorso CM,D'Antoni S,Brouwer JR,Bakker CE,Elia M,Ferri R,Nelson DL,Oostra BA,Catania MV

更新日期：2007-01-01 00:00:00

abstract：:Apnea of prematurity (AoP) is associated with severe and repeated episodes of arterial oxygen desaturation (intermittent hypoxia - IH), which in turn increases the number of apneas. So far, there is no data addressing whether IH leads to sex-specific respiratory consequences, neither if drugs targeting AoP are more ef...

journal_title：Experimental neurology

authors： Laouafa S,Iturri P,Arias-Reyes C,Marcouiller F,Gonzales M,Joseph V,Bairam A,Soliz J

更新日期：2019-10-01 00:00:00

abstract：:The functional and morphologic consequences of treatment of peripheral nerve lesions with exogenous 3,3',5-triiodo-L-thyronine (T3) are unclear. In this study adult Wistar rats with sciatic nerve crush lesions were treated with 20 micrograms/kg/day of T3. The treated animals gained weight though more slowly than vehic...

journal_title：Experimental neurology

authors： Allpress SJ,Pollock M

更新日期：1986-02-01 00:00:00

abstract：:Destruction of the entorhinal cortex (EC) triggers a number of cellular and molecular responses in the denervated hippocampus and dentate gyrus. The signals that trigger these changes are not known but could include physiological events that occur during the production of the injury or during the early postlesion peri...

journal_title：Experimental neurology

authors： Kelley MS,Steward O

更新日期：1996-05-01 00:00:00

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:The sympathetic innervation of lumbar dorsal root ganglia (DRGs) and the possible presence of spinal cord circuits connecting primary sensory afferents to the sympathetic outflow to DRGs were investigated. We used simultaneous tracing of the sympathetic input to and sensory output from DRGs. Adult male rats received u...

journal_title：Experimental neurology

authors： Hofstetter CP,Card JP,Olson L

更新日期：2005-07-01 00:00:00

abstract：:The aim of this study was to examine whether acute nerve compression damages an axonal transport system based on microtubules and how the fibers recover after the compression. A 5-mm segment of the tibial nerve of male wistar rat was compressed with a specially designed clip. Functional recovery was assessed using Tib...

journal_title：Experimental neurology

authors： Kitao A,Hirata H,Morita A,Yoshida T,Uchida A

更新日期：1997-10-01 00:00:00

abstract：:After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...

journal_title：Experimental neurology

authors： Bilchak JN,Yeakle K,Caron G,Malloy D,Côté MP

更新日期：2021-01-13 00:00:00

abstract：:We investigated the role of the NO/cGMP system in the vasodilatory response to hypercapnia after cortical spreading depression (CSD) in barbiturate anesthetized rats in vivo. Regional cerebral blood flow (rCBF) was measured by laser Doppler flowmetry (LDF). Hypercapnia (arterial pCO2 50-60 mm Hg) increased rCBF by 2.8...

journal_title：Experimental neurology

authors： Scheckenbach KE,Dreier JP,Dirnagl U,Lindauer U

更新日期：2006-12-01 00:00:00

abstract：:In the neocortex, the effectiveness of potential transplantation therapy for diseases involving neuronal loss may depend upon whether donor neurons can reestablish the precise long-distance projections that form the basis of sensory, motor, and cognitive function. During corticogenesis, the formation of these connecti...

journal_title：Experimental neurology

authors： Hernit-Grant CS,Macklis JD

更新日期：1996-05-01 00:00:00

abstract：:This paper focuses on transient boundaries of glia and glycoconjugates during development of the mouse central nervous system (CNS). Lectin-bound glycoconjugates, glial fibrillary acidic protein, and the J1/tenascin glycoprotein are distributed coextensively within boundaries around developing substructural arrangemen...

journal_title：Experimental neurology

authors： Steindler DA,O'Brien TF,Laywell E,Harrington K,Faissner A,Schachner M

更新日期：1990-07-01 00:00:00

abstract：:Dopaminergic projections to the caudate putamen (CPu) involve fibers in the nigrostriatal pathway from the ipsilateral substantia nigra-pars compacta. Post-synaptic receptor populations on cells receiving this information are composed of both D1 and D2 dopamine receptor subtypes. In the present study, unilateral lesio...

journal_title：Experimental neurology

authors： Narang N,Hunt ME,Pundt LL,Alburges ME,Wamsley JK

更新日期：1993-05-01 00:00:00

abstract：:Excitotoxic mechanisms may play a critical role in the pathophysiology of several neurological and psychiatric diseases. Excitatory amino acid receptor antagonists are therefore of great therapeutic interest, but untoward side effects often prevent their clinical use. Targeting the glycine coagonist site of the (NMDA)...

journal_title：Experimental neurology

authors： Guidetti P,Wu HQ,Schwarcz R

更新日期：2000-05-01 00:00:00

abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

journal_title：Experimental neurology

authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

更新日期：2014-01-01 00:00:00

abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...

journal_title：Experimental neurology

authors： Dinopoulos A,Dori I,Davies SW,Parnavelas JG

更新日期：1989-07-01 00:00:00

abstract：:Local field potential recordings made from the basal ganglia of patients undergoing deep brain stimulation have suggested that frequency specific activity is involved in determining the rate of force development and the peak force at the outset of a movement. However, the extent to which the basal ganglia might be inv...

journal_title：Experimental neurology

authors： Tan H,Pogosyan A,Anzak A,Foltynie T,Limousin P,Zrinzo L,Ashkan K,Bogdanovic M,Green AL,Aziz T,Brown P

更新日期：2013-02-01 00:00:00