Relationships between triggered seizures, spontaneous seizures, and interictal spiking in the kindling model of epilepsy.

abstract：:An important issue in stem cell biology relates to mechanisms of cellular plasticity. Specifically, could any observed multipotency of, e.g., adult stem cells arise from true transdifferentiation or as a result of cell-cell fusion? We studied this issue using a culture paradigm of astrocyte monolayers and multipotent ...

journal_title：Experimental neurology

authors： Chen KA,Laywell ED,Marshall G,Walton N,Zheng T,Steindler DA

更新日期：2006-03-01 00:00:00

abstract：:C2 spinal cord hemisection results in synaptic and astroglial changes in the phrenic nucleus which have been associated with the recovery of the ipsilateral hemidiaphragm during expression of the crossed phrenic phenomenon. As part of our ongoing analysis of the neurotransmitters involved, the present study investigat...

journal_title：Experimental neurology

authors： Hadley SD,Walker PD,Goshgarian HG

更新日期：1999-12-01 00:00:00

abstract：:A host protein encoded by the gene specifying the scrapie amyloid precursor affects pathogenesis of the transmissible spongiform encephalopathies: Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker's syndrome (GSS), and kuru in man, and scrapie in animals. We found a mutation in this gene of two patients ...

journal_title：Experimental neurology

authors： Goldgaber D,Goldfarb LG,Brown P,Asher DM,Brown WT,Lin S,Teener JW,Feinstone SM,Rubenstein R,Kascsak RJ

更新日期：1989-11-01 00:00:00

abstract：:Chronic administration of cocaine (10 mg/kg, i.p., every 12 h for 10 consecutive days) produced a large decrease in tyrosine hydroxylase-staining axons and terminal boutons in the caudate nucleus in rats when examined 60 days after the final cocaine injection. This effect was quantitated using the Leitz data acquisiti...

journal_title：Experimental neurology

authors： Trulson ME,Babb S,Joe JC,Raese JD

更新日期：1986-12-01 00:00:00

abstract：:In what ways do passive touch and active touch require particular properties of cortical physiology? Because it is not easy to make predictions "bottom up" from neurophysiology and anatomy to behavior, there have been surprises in studying behavioral deficits following selective ablations of SI versus SII. For example...

journal_title：Experimental neurology

authors： Glassman RB

更新日期：1994-01-01 00:00:00

abstract：:Glomerular convergence has been proposed to rely on interactions between like olfactory axons, however topographic targeting is influenced by guidance molecules encountered in the olfactory bulb. Disruption of these cues during development misdirects sensory axons, however little is known about the role of bulb-derive...

journal_title：Experimental neurology

authors： Ardiles Y,de la Puente R,Toledo R,Isgor C,Guthrie K

更新日期：2007-10-01 00:00:00

abstract：:An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life ...

journal_title：Experimental neurology

authors： Habgood MD,Hopkins WG

更新日期：1987-05-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:Multiple sclerosis (MS), the most frequent inflammatory disease of the central nervous system (CNS), affects about two and a half million individuals worldwide and causes major burdens to the patients, which develop the disease usually at the age of 20 to 40. MS is likely referable to a breakdown of immune cell tolera...

journal_title：Experimental neurology

authors： Schattling B,Eggert B,Friese MA

更新日期：2014-12-01 00:00:00

abstract：:Spinal cord injury (SCI) causes motor and sensory deficits that impair functional performance. While more functional recovery occurs with greater white matter sparing (WMS), it is unclear which locomotor features are more vulnerable to SCI than others, if recovery of certain features depends on specific amounts of WMS...

journal_title：Experimental neurology

authors： Kloos AD,Fisher LC,Detloff MR,Hassenzahl DL,Basso DM

更新日期：2005-02-01 00:00:00

abstract：:Intranuclear inclusion bodies are a shared pathological feature of Huntington's disease (HD) and its transgenic mouse model. Using a panel of antibodies spanning the entire huntingtin molecule, we have investigated the pattern of immunoreactivity within the intranuclear inclusions in the frontal cortex and striatum of...

journal_title：Experimental neurology

authors： Sieradzan KA,Mechan AO,Jones L,Wanker EE,Nukina N,Mann DM

更新日期：1999-03-01 00:00:00

abstract：:The repair of nerve gap injuries with tubular nerve guides has been used extensively as an in vivo test model in identifying substances which may enhance nerve regeneration. The model has also been used clinical nerve repair. The objective of this study was to compare three different gel matrix-forming materials as po...

journal_title：Experimental neurology

authors： Wells MR,Kraus K,Batter DK,Blunt DG,Weremowitz J,Lynch SE,Antoniades HN,Hansson HA

更新日期：1997-08-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a regulator of rodent embryogenesis during the period of neural tube closure. VIP enhanced growth in whole cultured mouse embryos; treatment with a VIP antagonist during embryogenesis inhibited growth and development. VIP antagonist treatment during embryogenesis also had permane...

journal_title：Experimental neurology

authors： Hill JM,Cuasay K,Abebe DT

更新日期：2007-07-01 00:00:00

abstract：:Infant rats were subjected to pentylenetetrazol-induced convulsions on alternate days from 5 to 13 days of age. At 17 days of age, their susceptibility to the convulsant effects of hyperthermia was examined. It was found that previous pentylenetetrazol-induced convulsions caused a significant facilitation in the devel...

journal_title：Experimental neurology

authors： McCaughran JA Jr,Manetto C

更新日期：1983-01-01 00:00:00

abstract：:Overactivation of N-methyl-D-aspartate (NMDA) glutamate receptors is closely related to epilepsy and excitotoxicity, and the phosphorylation of these receptors may facilitate glutamate-mediated synaptic transmission. Here we show that in awake rats the microinjection into the hippocampus of okadaic acid, a potent inhi...

journal_title：Experimental neurology

authors： Arias C,Montiel T,Peña F,Ferrera P,Tapia R

更新日期：2002-09-01 00:00:00

abstract：:To ascertain whether signaling due to peripheral inflammation affects motoneuron vulnerability, we examined in adult rats the reaction to axonal injury of facial motoneurons primed by muscle inflammation. In this double-hit paradigm, preconditioning was achieved by injections into the facial muscles of the T cell mito...

journal_title：Experimental neurology

authors： Mariotti R,Tongiorgi E,Bressan C,Kristensson K,Bentivoglio M

更新日期：2002-07-01 00:00:00

abstract：:One of the sexual dimorphic differences in adult rodents is neural proliferation. Here we demonstrate that physiological hormone stages can modulate this proliferation in the adult forebrain. Female mice, both pregnant and synchronized in oestrus, exhibited higher proliferating cell percentages than males in both the ...

journal_title：Experimental neurology

authors： Díaz D,Valero J,Airado C,Baltanás FC,Weruaga E,Alonso JR

更新日期：2009-04-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:We conducted a quantitative study of the trochlear motoneurons and the myotube clusters in the corresponding superior oblique muscle of the Japanese quail, before, during, and after the period of normally occurring motoneuron degeneration. A ratio of approximately 1:1 between myotube clusters and neurons was observed ...

journal_title：Experimental neurology

authors： Arumugam T,Sohal GS

更新日期：1985-10-01 00:00:00

abstract：:Traumatic brain injury (TBI) in animals and man generates widespread axonal injury characterized by focal axolemmal permeability changes, induction of calpain-mediated proteolysis, and neurofilament side-arm modification associated with neurofilament compaction (NFC) evolving to axonal disconnection. Recent observatio...

journal_title：Experimental neurology

authors： Büki A,Koizumi H,Povlishock JT

更新日期：1999-09-01 00:00:00

abstract：:The tooth pulp-evoked jaw-opening reflex was studied in the barbiturate-anesthetized cat. At liminal intensity of the stimulus, a stable short-latency response was obtained in the digastricus and in the tongue. At a higher stimulus intensity, there occasionally appeared to be a prolonged discharge of variable duration...

journal_title：Experimental neurology

authors： Pertovaara A,Huopaniemi T,Aukee K

更新日期：1986-04-01 00:00:00

abstract：:The majority of human spinal cord injuries involve gray matter loss from the cervical or lumbar enlargements. However, the deficits that arise from gray matter damage are largely masked by the severe deficits due to associated white matter damage. We have developed a model to examine gray matter-specific deficits and ...

journal_title：Experimental neurology

authors： Magnuson DS,Trinder TC,Zhang YP,Burke D,Morassutti DJ,Shields CB

更新日期：1999-03-01 00:00:00

abstract：:We have previously shown that the expression of voltage-operated Ca(++) channels (VOCCs) is highly regulated in the oligodendroglial lineage and is essential for proper oligodendrocyte progenitor cell (OPC) migration. Here we assessed the role of VOCCs, in particular the L-type, in oligodendrocyte maturation. We used ...

journal_title：Experimental neurology

authors： Cheli VT,Santiago González DA,Spreuer V,Paez PM

更新日期：2015-03-01 00:00:00

abstract：:The effects of a trigeminal tractotomy on nociceptive reactions induced by electrical stimulation of an inferior incisor were studied in freely moving rats. Behavioral tests were based on the observation of three reactions: jaw opening reflex, face scratching with forepaws, and head rotation toward the stimulated side...

journal_title：Experimental neurology

authors： Dallel R,Clavelou P,Woda A

更新日期：1989-10-01 00:00:00

abstract：:This study characterizes the impact of increasing-intensity treadmill exercise (iTR) on noradrenergic (NE) and serotonergic (5HT) modulation of neuropathic pain. Following sciatic nerve transection and repair (SNTR) rats developed significant mechanical and thermal hyperalgesia that was partially prevented by iTR perf...

journal_title：Experimental neurology

authors： Lopez-Alvarez VM,Puigdomenech M,Navarro X,Cobianchi S

更新日期：2018-01-01 00:00:00

abstract：:In order to evaluate neurologic development, postural reflexes were tested in normal kittens from birth through 7 weeks of age until stable adult patterns of performance were attained. These reflex tests included: body and air righting, visual placing, chin placing, tactile placing, hopping, and locomotion. A protocol...

journal_title：Experimental neurology

authors： Sechzer JA,Folstein SE,Geiger EH,Mervis RF,Meehan SM

更新日期：1984-12-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) support axon regeneration across artificial nerve bridges but their differentiative capacity and ability to promote nerve regeneration remains unclear. In this study, MSCs isolated from bone marrow of Sprague-Dawley rats were characterized by plastic adherence and pluripotency towards mes...

journal_title：Experimental neurology

authors： Ladak A,Olson J,Tredget EE,Gordon T

更新日期：2011-04-01 00:00:00

abstract：:The beta-Amyloid peptide (A beta) is hypothesized to mediate the neurodegeneration seen in Alzheimer's disease. Recently, we proposed a new hypothesis to explain the toxicity of A beta based on the free-radical generating capacity of A beta. We have recently demonstrated using electron paramagnetic resonance (EPR) spe...

journal_title：Experimental neurology

authors： Harris ME,Hensley K,Butterfield DA,Leedle RA,Carney JM

更新日期：1995-02-01 00:00:00

abstract：:Among endogenous adaptive systems to hypoxia, neuroglobin, a recently discovered heme protein, was suggested as a novel oxygen-dependent neuroprotectant. We aimed to characterize i) maturational age-related regulation of neuroglobin in the developing mouse brain under normoxic and hypoxic conditions, and ii) the role ...

journal_title：Experimental neurology

authors： Hümmler N,Schneider C,Giessl A,Bauer R,Walkinshaw G,Gassmann M,Rascher W,Trollmann R

更新日期：2012-07-01 00:00:00