Cerebrospinal fluid pressure during cerebroventricular infusion of angiotensin and vasopressin.

abstract：:One of the primary hallmarks of glutamate excitotoxicity is degradation of the neuronal cytoskeleton. Using a tissue culture approach, we have investigated the relationship between excitotoxicity and cytoskeletal degradation within axons, with particular reference to the axon specific neurofilament proteins. Neurofila...

journal_title：Experimental neurology

authors： Chung RS,McCormack GH,King AE,West AK,Vickers JC

更新日期：2005-06-01 00:00:00

abstract：:Intractable pain is the single most common cause of disability, affecting more than 20% of the population world-wide. There is accordingly a global effort to decipher how changes in nociceptive processing in the peripheral and central nervous systems contribute to the onset and maintenance of chronic pain. The past se...

journal_title：Experimental neurology

authors： Xie YF,Wang J,Bonin RP

更新日期：2018-08-01 00:00:00

abstract：:Parkinson's disease is a neurodegenerative disorder associated with selective loss of the dopaminergic neurons in the substantia nigra. We have previously shown that tetrahydrobiopterin (BH4), the obligatory cofactor for dopamine synthesis, exerts selective toxicity on dopamine-producing cells. In the present study we...

journal_title：Experimental neurology

authors： Choi HJ,Kim SW,Lee SY,Moon YW,Hwang O

更新日期：2003-06-01 00:00:00

abstract：:Heme oxygenase-1 is a cellular stress protein expressed in brain and other tissues in response to oxidative challenge and other noxious stimuli. In the present study, immunohistochemistry was used to assess HO-1 expression in various postmortem human brain specimens derived from PD and control subjects. In the substan...

journal_title：Experimental neurology

authors： Schipper HM,Liberman A,Stopa EG

更新日期：1998-03-01 00:00:00

abstract：:Hippocampal transplants were examined for the expression of three specific immediate early gene encoded proteins in order to establish if grafted immature tissue maintains the basic molecular program necessary for gene transcription after grafting to excitotoxic (ibotenic acid-induced) lesions in adult host rat brains...

journal_title：Experimental neurology

authors： Aznar S,Tønder N,Bele S,Kiessling M,Zimmer J,Gass P

更新日期：1995-12-01 00:00:00

abstract：:This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...

journal_title：Experimental neurology

authors： Bergman H,Prell GD,Lupica CR,Granholm AC

更新日期：1995-11-01 00:00:00

abstract：:The sciatic nerve of the rat is a commonly used model for studies on nerve injury, regeneration, and recovery of function. To interpret the changes that occur in a neuron population subsequent to peripheral nerve injury, and to compare different repair procedures, it is essential to have a complete and accurate unders...

journal_title：Experimental neurology

authors： Swett JE,Wikholm RP,Blanks RH,Swett AL,Conley LC

更新日期：1986-07-01 00:00:00

abstract：:Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...

journal_title：Experimental neurology

authors： Matsui T,Akamatsu W,Nakamura M,Okano H

更新日期：2014-10-01 00:00:00

abstract：:Extracellular unit activity from 29 neurons in the preoptic area was recorded together with the cortical EEG in encéphale isolé cats. A majority (55%) of neurons showed alterations in their firing rates during transient changes in the EEG. Among them, a majority (62.5%) showed an increased firing rate during synchroni...

journal_title：Experimental neurology

authors： Mallick BN,Chhina GS,Sundaram KR,Singh B,Kumar VM

更新日期：1983-09-01 00:00:00

abstract：:In order to study the ocular dominance and responsiveness of cells in the deafferented visual cortex, the geniculate and the callosal inputs were interrupted in adult cats by either simultaneous (OTCCX) or separate surgical transection of the optic tract (OTX) and the posterior corpus callosum (CCX). Unit recording wa...

journal_title：Experimental neurology

authors： Yinon U,Achiron A

更新日期：1988-03-01 00:00:00

abstract：:Hyperbaric oxygenation is known to affect energy metabolism and endothelial cell structure and function, but its effects on peripheral nerve have not been reported. We investigated whether it would (i) reverse established streptozotocin-induced diabetic neuropathy, a condition in which endoneurial hypoxia exists; (ii)...

journal_title：Experimental neurology

authors： Low PA,Schmelzer JD,Ward KK,Curran GL,Poduslo JF

更新日期：1988-01-01 00:00:00

abstract：:Increased intercellular coupling has been implicated in contributing to the synchronization of discharges characteristic of epileptic foci. Using RNA blot analysis, the level of mRNA for the heart-type gap junction protein, connexin43, is shown to be elevated in samples of temporal lobe neocortex obtained at the time ...

journal_title：Experimental neurology

authors： Naus CC,Bechberger JF,Paul DL

更新日期：1991-02-01 00:00:00

abstract：:Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastro...

journal_title：Experimental neurology

authors： Younger LE,Silverman H

更新日期：1984-04-01 00:00:00

abstract：:We have investigated the long-term effects of 15-16 min or 19-20 min of perinatal asphyxia on D1, D2, and D3 receptors (analyzed by quantitative autoradiography) in the mesotelencephalic dopamine systems of the 4-week-old rat. Perinatal asphyxia reduced D1 antagonist binding ([3H]SCH 23390 in the presence of ketanseri...

journal_title：Experimental neurology

authors： Chen Y,Hillefors-Berglund M,Herrera-Marschitz M,Bjelke B,Gross J,Andersson K,von Euler G

更新日期：1997-07-01 00:00:00

abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...

journal_title：Experimental neurology

authors： Galati S,Song W,Orban G,Luft AR,Kaelin-Lang A

更新日期：2018-03-01 00:00:00

abstract：:Recent studies have implicated nitric oxide (NO) in several mechanisms related to neuronal degeneration and synaptic plasticity. In the present study, two models of traumatic neuronal injury were used to examine the expression of NOS following neuronal injury and its relationship to axonal sprouting and neuronal degen...

journal_title：Experimental neurology

authors： Wu W

更新日期：1993-04-01 00:00:00

abstract：:Parkinson's disease (PD) is characterized by the polymerization of wild-type (WT) or mutant alpha-synuclein (AS) into aggregates and fibrils, which are observed as Lewy bodies (LBs) and Lewy neurites (LNs) in PD patients. However, inability to demonstrate aggregation in many cell culture systems is a major drawback fo...

journal_title：Experimental neurology

authors： Pandey N,Schmidt RE,Galvin JE

更新日期：2006-02-01 00:00:00

abstract：:Exposure to low doses of gamma irradiation results in the modification of both the antinociceptive properties of morphine and the severity of naloxone-precipitated withdrawal in morphine-dependent rats. To better define the interactions between gamma irradiation and these opiate-mediated phenomena, dose-response studi...

journal_title：Experimental neurology

authors： Dougherty PM,Dafny N

更新日期：1987-11-01 00:00:00

abstract：:The ST14A cell line was previously derived from embryonic day 14 rat striatal primordia by retroviral transduction of the temperature-sensitive SV40 large T antigen. We showed that cell division and expression of nestin persists at 33 degrees C, the permissive temperature, whereas cell division ceases, nestin expressi...

journal_title：Experimental neurology

authors： Ehrlich ME,Conti L,Toselli M,Taglietti L,Fiorillo E,Taglietti V,Ivkovic S,Guinea B,Tranberg A,Sipione S,Rigamonti D,Cattaneo E

更新日期：2001-02-01 00:00:00

abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

journal_title：Experimental neurology

authors： Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

更新日期：2005-01-01 00:00:00

abstract：:While past neuroimaging methods have contributed greatly to our understanding of brain function after traumatic brain injury (TBI), resting state functional MRI (rsfMRI) connectivity methods have more recently provided a far more unbiased approach with which to monitor brain circuitry compared to task-based approaches...

journal_title：Experimental neurology

authors： Harris NG,Verley DR,Gutman BA,Thompson PM,Yeh HJ,Brown JA

更新日期：2016-03-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:A central role for noradrenergic dysregulation in the pathophysiology of post-traumatic stress disorder (PTSD) is increasingly suggested by both clinical and basic neuroscience research. Here, we integrate recent findings from clinical and animal research with the earlier literature. We first review the evidence for n...

journal_title：Experimental neurology

authors： Hendrickson RC,Raskind MA

更新日期：2016-10-01 00:00:00

abstract：:Many neurological and psychiatric disorders exhibit gender disparities, and sex differences in the brain likely explain some of these effects. Recent work in rodents points to a role for epigenetics in the development or maintenance of neural sex differences, although genome-wide studies have so far been lacking. Here...

journal_title：Experimental neurology

authors： Shen EY,Ahern TH,Cheung I,Straubhaar J,Dincer A,Houston I,de Vries GJ,Akbarian S,Forger NG

更新日期：2015-06-01 00:00:00

abstract：:Ghrelin, a 28-amino acid peptide, is an endogenous ligand for the growth hormone secretagogue (GHS) receptor. Our previous data showed that ghrelin could inhibit apoptosis in Parkinson's disease (PD) models both in vitro and in vivo. There is now growing evidence that oxidative stress has a critical role in the etiolo...

journal_title：Experimental neurology

authors： Liu L,Xu H,Jiang H,Wang J,Song N,Xie J

更新日期：2010-03-01 00:00:00

abstract：:We provide evidence for apoptosis in Alzheimer's disease using the in situ labeling technique TUNEL (terminal transferase-mediated dUTP-biotin nick end labeling). The technique specifically detects apoptotic cells by utilizing terminal transferase to incorporate biotinylated nucleotides into the fragmented DNA of apop...

journal_title：Experimental neurology

authors： Smale G,Nichols NR,Brady DR,Finch CE,Horton WE Jr

更新日期：1995-06-01 00:00:00

abstract：:Tamoxifen-induced mutagenesis via the so-called CreER(T2) fusion enzyme is a key technology for the inducible gene knockout in the adult murine brain. However, it requires a subchronic transient treatment with high doses of the non-selective estrogen receptor antagonist tamoxifen. It has been shown earlier that acute ...

journal_title：Experimental neurology

authors： Vogt MA,Chourbaji S,Brandwein C,Dormann C,Sprengel R,Gass P

更新日期：2008-05-01 00:00:00

abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...

journal_title：Experimental neurology

authors： Leibowitz SF,Eidelman D,Suh JS,Diaz S,Sladek CD

更新日期：1990-12-01 00:00:00

abstract：BACKGROUND:Medial forebrain bundle (MFB) deep brain stimulation (DBS) has anti-depressant effects clinically and in depression models. Currently, therapeutic mechanisms of MFB DBS or how stimulation parameters acutely impact neurotransmitter release, particularly dopamine, are unknown. Experimentally, MFB DBS has been ...

journal_title：Experimental neurology

authors： Ashouri Vajari D,Ramanathan C,Tong Y,Stieglitz T,Coenen VA,Döbrössy MD

更新日期：2020-05-01 00:00:00

abstract：:Neglect is a clinical syndrome characterized by an inability to orient, report, or respond to novel or meaningful stimuli presented to one side of the body or in one hemispace. Neglect in humans and monkeys most often results from damage to one of several interconnected cortical areas, including limbic cortex. In rats...

journal_title：Experimental neurology

authors： King V,Corwin JV,Reep RL

更新日期：1989-09-01 00:00:00