Subfornical organ efferents influence the activity of median preoptic neurons projecting to the hypothalamic paraventricular nucleus in the rat.

Abstract:

:Twelve neurons in the median preoptic nucleus were antidromically activated by electrical stimulation of the hypothalamic paraventricular nucleus in the rat. Electrical stimulation of the subfornical organ produced excitation (N = 7) or inhibition (N = 4) of the activity of these identified units. The activity of all identified units that were excited by stimulation of the subfornical organ was also excited by microiontophoretically applied angiotensin II whereas the remaining units were not affected. The excitatory responses of the identified units to subfornical organ stimulation or applied angiotension II were blocked by saralasin, an angiotensin II antagonist.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Tanaka J,Kaba H,Saito H,Seto K

doi

10.1016/0014-4886(86)90184-6

subject

Has Abstract

pub_date

1986-09-01 00:00:00

pages

647-51

issue

3

eissn

0014-4886

issn

1090-2430

journal_volume

93

pub_type

杂志文章
  • Increased amyloid protein precursor and apolipoprotein E immunoreactivity in the selectively vulnerable hippocampus following transient forebrain ischemia in gerbils.

    abstract::The postischemic time course of amyloid protein precursor (APP), beta-amyloid protein (beta-AP), and apolipoprotein E (APO-E) immunoreactivity were examined in comparison to neuronal necrosis in the selectively vulnerable hippocampal CA1 region of gerbils subjected to 10 min of bilateral carotid occlusion-induced fore...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1006/exnr.1995.1062

    authors: Hall ED,Oostveen JA,Dunn E,Carter DB

    更新日期:1995-09-01 00:00:00

  • Apolipoprotein E epsilon4 allele has no effect on age at onset or duration of disease in cases of frontotemporal dementia with pick- or microvacuolar-type histology.

    abstract::Frontotemporal dementia (FTD) is the second most common cause of presenile dementia. Here we have investigated the frequency of the epsilon4 allele of the Apolipoprotein (APOE) gene in FTD and in other non-Alzheimer forms of dementia related to FTD such as Motor Neurone disease dementia, semantic dementia, progressive...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1006/exnr.2000.7387

    authors: Pickering-Brown SM,Owen F,Isaacs A,Snowden J,Varma A,Neary D,Furlong R,Daniel SE,Cairns NJ,Mann DM

    更新日期:2000-06-01 00:00:00

  • Intranasal insulin restores insulin signaling, increases synaptic proteins, and reduces Aβ level and microglia activation in the brains of 3xTg-AD mice.

    abstract::Decreased brain insulin signaling has been found recently in Alzheimer's disease (AD). Intranasal administration of insulin, which delivers the drug directly into the brain, improves memory and cognition in both animal studies and small clinical trials. However, the underlying mechanisms are unknown. Here, we treated ...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2014.06.004

    authors: Chen Y,Zhao Y,Dai CL,Liang Z,Run X,Iqbal K,Liu F,Gong CX

    更新日期:2014-11-01 00:00:00

  • Inflammation-induced GluA1 trafficking and membrane insertion of Ca2+ permeable AMPA receptors in dorsal horn neurons is dependent on spinal tumor necrosis factor, PI3 kinase and protein kinase A.

    abstract::Peripheral inflammation induces sensitization of nociceptive spinal cord neurons. Both spinal tumor necrosis factor (TNF) and neuronal membrane insertion of Ca2+ permeable AMPA receptor (AMPAr) contribute to spinal sensitization and resultant pain behavior, molecular mechanisms connecting these two events have not bee...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2017.04.004

    authors: Wigerblad G,Huie JR,Yin HZ,Leinders M,Pritchard RA,Koehrn FJ,Xiao WH,Bennett GJ,Huganir RL,Ferguson AR,Weiss JH,Svensson CI,Sorkin LS

    更新日期:2017-07-01 00:00:00

  • Programmed cell death in developing grafts of fetal substantia nigra.

    abstract::Intracerebral transplants of ventral mesencephalic (VM) tissue have been well characterized. VM grafts contain numerous tyrosine hydroxylase immunoreactive neurons which send axons into the host brain. Transplanted neurons in VM grafts develop normally in that they contain tyrosine hydroxylase and GAP43. An overlooked...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1006/exnr.1994.1144

    authors: Mahalik TJ,Hahn WE,Clayton GH,Owens GP

    更新日期:1994-09-01 00:00:00

  • Effect of L-carnitine on nucleic acid status of aged rat brain.

    abstract::The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2004.09.009

    authors: Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

    更新日期:2005-01-01 00:00:00

  • GM1 ganglioside treatment of spontaneously hypertensive stroke prone rats.

    abstract::Many reports indicate that GM1 ganglioside is effective in reducing CNS ischemic injury in animal models. These models employ invasive surgery to induce ischemic damage in otherwise healthy animals. The purpose of this study was to determine if the beneficial effects of GM1 could be generalized to Spontaneously Hypert...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1006/exnr.1994.1045

    authors: Hernandez NE,MacDonall JS,Stier CT Jr,Belmonte A,Fernandez R,Karpiak SE

    更新日期:1994-03-01 00:00:00

  • The relationships among the severity of spinal cord injury, residual neurological function, axon counts, and counts of retrogradely labeled neurons after experimental spinal cord injury.

    abstract::Substantial residual neurological function may persist after spinal cord injury (SCI) with survival of as few as 5-10% of the original number of axons. A detailed understanding of the relationships among the severity of injury, the number and origin of surviving axons at the injury site, and the extent of neurological...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(95)90027-6

    authors: Fehlings MG,Tator CH

    更新日期:1995-04-01 00:00:00

  • Tumor necrosis factor receptor 1 and 2 proteins are differentially regulated during Wallerian degeneration of mouse sciatic nerve.

    abstract::The pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) is involved in injury-induced peripheral nerve pathology and in the generation of neuropathic pain. Here, we investigated local protein levels of the two known TNF receptors, TNF receptor 1 and 2 (TNFR1, TNFR2), on days 0, 1, 3, 7, 14, and 28 after unilat...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2004.11.002

    authors: George A,Buehl A,Sommer C

    更新日期:2005-03-01 00:00:00

  • A longitudinal DTI and histological study of the spinal cord reveals early pathological alterations in G93A-SOD1 mouse model of amyotrophic lateral sclerosis.

    abstract::Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by selective motor neuron degeneration in the motor cortex, brainstem and spinal cord. It is generally accepted that ALS is caused by death of motor neurons, however the exact temporal cascade of degenerative processes is not yet complete...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2017.03.018

    authors: Marcuzzo S,Bonanno S,Figini M,Scotti A,Zucca I,Minati L,Riva N,Domi T,Fossaghi A,Quattrini A,Galbardi B,D'Alessandro S,Bruzzone MG,García-Verdugo JM,Moreno-Manzano V,Mantegazza R,Bernasconi P

    更新日期:2017-07-01 00:00:00

  • The effect of type 2 diabetes on CD36 expression and the uptake of oxLDL: Diabetes affects CD36 and oxLDL uptake.

    abstract::We investigated whether type 2 diabetes mellitus (T2DM), a risk factor of stroke, affects the level of scavenger receptor CD36 and the uptake of its ligand, oxidized LDL (oxLDL); and whether pioglitazone, a drug that enhances CD36, promotes oxLDL uptake. Compared to normoglycemic db/+ mice, adult db/db mice showed a p...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2020.113461

    authors: Kanoke A,Nishijima Y,Ljungberg M,Omodaka S,Yang SY,Wong S,Rabiller G,Tominaga T,Hsieh CL,Liu J

    更新日期:2020-12-01 00:00:00

  • Cyclic AMP elevates tubulin expression without increasing intrinsic axon growth capacity.

    abstract::Exposing rat dorsal root ganglion (DRG) neurons to dibutyryl cAMP (db-cAMP) enables central branches to regenerate in the spinal cord by nullifying the ability of CNS myelin to inhibit elongation. A conditioning lesion (CL) promotes similar regeneration of central branches in the spinal cord by increasing neuronal cAM...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2004.03.010

    authors: Han PJ,Shukla S,Subramanian PS,Hoffman PN

    更新日期:2004-10-01 00:00:00

  • CD11d integrin blockade reduces the systemic inflammatory response syndrome after traumatic brain injury in rats.

    abstract::Traumatic CNS injury triggers a systemic inflammatory response syndrome (SIRS), in which circulating inflammatory cells invade body organs causing local inflammation and tissue damage. We have shown that the SIRS caused by spinal cord injury is greatly reduced by acute intravenous treatment with an antibody against th...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2015.07.003

    authors: Weaver LC,Bao F,Dekaban GA,Hryciw T,Shultz SR,Cain DP,Brown A

    更新日期:2015-09-01 00:00:00

  • Alternative splicing of AMPA receptor subunits in the 6-OHDA-lesioned rat model of Parkinson's disease and L-DOPA-induced dyskinesia.

    abstract::Abnormal corticostriatal plasticity is a key mechanism of L-DOPA-induced dyskinesia (LID) in Parkinson's disease (PD). Antagonists at glutamatergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, such as IEM 1460, reduce induction and expression of dyskinesia in rat and non-human primate models ...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2013.01.019

    authors: Kobylecki C,Crossman AR,Ravenscroft P

    更新日期:2013-09-01 00:00:00

  • Spinal RyR2 pathway regulated by the RNA-binding protein HuD induces pain hypersensitivity in antiretroviral neuropathy.

    abstract::The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2015.02.036

    authors: Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

    更新日期:2015-05-01 00:00:00

  • Changes in the cholinergic system of rat sciatic nerve and skeletal muscle following suspension-induced disuse.

    abstract::Muscle disuse-induced changes in the cholinergic system of sciatic nerve, slow-twitch soleus (SOL), and fast-twitch extensor digitorum longus (EDL) muscles were studied in rats. Rats with hind limbs suspended for 2 to 3 weeks showed marked elevation in the activity of choline acetyltransferase in sciatic nerve (38%), ...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(85)90012-3

    authors: Gupta RC,Misulis KE,Dettbarn WD

    更新日期:1985-09-01 00:00:00

  • Spontaneous neuronal activity in fetuses and newborns.

    abstract::We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2004.06.026

    authors: Rose DF,Eswaran H

    更新日期:2004-11-01 00:00:00

  • Nigral dopamine type-1 receptors are reduced in Huntington's disease: a postmortem autoradiographic study using [3H]SCH 23390 and correlation with [3H]forskolin binding.

    abstract::Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(90)90033-o

    authors: Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

    更新日期:1990-11-01 00:00:00

  • Spinal ERK activation contributes to the regulation of bladder function in spinal cord injured rats.

    abstract::The extracellular signal-regulated kinase 1 and 2 (ERK) pathway, regulated by phosphorylation on specific amino acids, is emerging as an important signaling cascade in neurones, transducing sensory input into cellular responses. In the mammalian nervous system, the ERK pathway has been found to mediate plasticity even...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2006.01.016

    authors: Cruz CD,McMahon SB,Cruz F

    更新日期:2006-07-01 00:00:00

  • A novel assay for the in vivo study of Schwann cells.

    abstract::An in vivo assay was developed for long-term analyses of Schwann cells at the single cell level. Schwann cells were isolated from sciatic nerves and labeled with the fluorescent gold label Fluoro-Gold. Cells were then transplanted into severed sciatic nerves of young adult rats. Gold-labeled Schwann cells, identified ...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(91)90092-q

    authors: Daniloff JK

    更新日期:1991-10-01 00:00:00

  • The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

    abstract::We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related t...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1006/exnr.2000.7515

    authors: Xu K,Dluzen DE

    更新日期:2000-12-01 00:00:00

  • Estetrol attenuates neonatal hypoxic-ischemic brain injury.

    abstract::Estetrol (E4) is a recently described natural estrogen with four hydroxyl-groups that is synthesized exclusively during pregnancy by the human fetal liver. It has important antioxidative activity. The aim of the present study was to define the importance of E4 in the attenuation of neonatal hypoxic-ischemic encephalop...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2014.07.015

    authors: Tskitishvili E,Nisolle M,Munaut C,Pequeux C,Gerard C,Noel A,Foidart JM

    更新日期:2014-11-01 00:00:00

  • Long-term observation of auto-cell transplantation in non-human primate reveals safety and efficiency of bone marrow stromal cell-derived Schwann cells in peripheral nerve regeneration.

    abstract::Based on their differentiation ability, bone marrow stromal cells (MSCs) are a good source for cell therapy. Using a cynomolgus monkey peripheral nervous system injury model, we examined the safety and efficacy of Schwann cells induced from MSCs as a source for auto-cell transplantation therapy in nerve injury. Serial...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2010.01.022

    authors: Wakao S,Hayashi T,Kitada M,Kohama M,Matsue D,Teramoto N,Ose T,Itokazu Y,Koshino K,Watabe H,Iida H,Takamoto T,Tabata Y,Dezawa M

    更新日期:2010-06-01 00:00:00

  • Laminar field potentials and unit activity in the cortex during visual evoked potentials in feline generalized penicillin epilepsy.

    abstract::Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(86)90229-3

    authors: Pellegrini A,Zanotto L,Ermani M,Chemello R,Testa G

    更新日期:1986-12-01 00:00:00

  • Sarcomere length in normal and dystrophic chick muscles.

    abstract::An electron microscope study of 2- and 8-week-old normal and dystrophic chickens compared sarcomere lengths in relaxed and passively extended Patagialis (PAT) muscles. Sarcomeres were measured in dystrophic muscles only in fibers which exhibited no morphological signs of degeneration. Sarcomere lengths were not differ...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/0014-4886(88)90005-2

    authors: Ashmore CR,Mechling K,Lee YB

    更新日期:1988-08-01 00:00:00

  • Tyrosine hydroxylase is expressed in a subpopulation of small dorsal root ganglion neurons in the adult mouse.

    abstract::The expression of tyrosine hydroxylase (TH) was studied in adult mouse dorsal root ganglia (DRGs) and spinal cord by means of immunohistochemistry and in situ hybridization. TH immunoreactivity and TH mRNA were present in 10-15% of lumbar DRG neurons, in most cases being small/medium-sized. Only very few of these neur...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2006.01.023

    authors: Brumovsky P,Villar MJ,Hökfelt T

    更新日期:2006-07-01 00:00:00

  • Glutamate promotes NF-kappaB pathway in primary astrocytes: protective effects of IRFI 016, a synthetic vitamin E analogue.

    abstract::Oxidative stress has been implicated in several neurodegenerative diseases affecting both neuronal and glial cells. The aim of this study was to investigate the involvement of reactive oxygen species in glutamate-evoked activation of NF-kappaB in primary astrocytes. A prolonged exposure to glutamate (24 h) caused a de...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2005.01.014

    authors: Caccamo D,Campisi A,Marini H,Adamo EB,Li Volti G,Squadrito F,Ientile R

    更新日期:2005-06-01 00:00:00

  • Traumatic brain injuries during development disrupt dopaminergic signaling.

    abstract::Traumatic brain injuries (TBI) sustained during peri-adolescent development produce lasting neuro-behavioral changes that render individuals at an increased risk for developing substance abuse disorders. Experimental and clinical evidence of a prolonged period of hypodopaminergia after TBI have been well documented, b...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2017.08.003

    authors: Karelina K,Gaier KR,Weil ZM

    更新日期:2017-11-01 00:00:00

  • Sciatic nerve regeneration is accelerated in galectin-3 knockout mice.

    abstract::The success of peripheral nerve regeneration depends on intrinsic properties of neurons and a favorable environment, although the mechanisms underlying the molecular events during degeneration and regeneration are still not elucidated. Schwann cells are considered one of the best candidates to be closely involved in t...

    journal_title:Experimental neurology

    pub_type: 杂志文章

    doi:10.1016/j.expneurol.2009.01.008

    authors: Narciso MS,Mietto Bde S,Marques SA,Soares CP,Mermelstein Cdos S,El-Cheikh MC,Martinez AM

    更新日期:2009-05-01 00:00:00

  • Piriform cortex ictogenicity in vitro.

    abstract::The piriform cortex is recognized to play critical roles in focal ictogenesis, both in animal models and in humans. We review here the contribution of in vitro studies performed on rodent brain tissue that were aimed at understanding the ictogenic properties of the piriform cortex and the contiguous olfactory areas. D...

    journal_title:Experimental neurology

    pub_type: 杂志文章,评审

    doi:10.1016/j.expneurol.2019.113014

    authors: de Curtis M,Uva L,Lévesque M,Biella G,Avoli M

    更新日期:2019-11-01 00:00:00