Sialylated intravenous immunoglobulin suppress anti-ganglioside antibody mediated nerve injury.

abstract：:An electron microscope study of 2- and 8-week-old normal and dystrophic chickens compared sarcomere lengths in relaxed and passively extended Patagialis (PAT) muscles. Sarcomeres were measured in dystrophic muscles only in fibers which exhibited no morphological signs of degeneration. Sarcomere lengths were not differ...

journal_title：Experimental neurology

authors： Ashmore CR,Mechling K,Lee YB

更新日期：1988-08-01 00:00:00

abstract：:Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fib...

journal_title：Experimental neurology

authors： Girlanda P,Muglia U,Vita G,Dattola R,Santoro M,Toscano A,Venuto C,Roberto ML,Baradello A,Romano M

更新日期：1988-02-01 00:00:00

abstract：:Alzheimer's disease (AD) is the leading cause of dementia and the most common neurodegenerative disorder. AD is mostly a sporadic disorder and its main risk factor is age, but mutations in three genes that promote the accumulation of the amyloid-β (Aβ42) peptide revealed the critical role of amyloid precursor protein ...

journal_title：Experimental neurology

authors： Fernandez-Funez P,de Mena L,Rincon-Limas DE

更新日期：2015-12-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) is the most devastating form of stroke. Reducing neuronal apoptosis is an important countermeasure against early brain injury (EBI) after SAH. Recent evidence indicates that OX40-OX40L coupling is critical for cell survival and proliferation. Current study was performed to detect the role...

journal_title：Experimental neurology

authors： Wu LY,Enkhjargal B,Xie ZY,Travis ZD,Sun CM,Zhou KR,Zhang TY,Zhu QQ,Hang CH,Zhang JH

更新日期：2020-04-01 00:00:00

abstract：:Chronic intrastriatal administration of quinolinic acid (QA) in the rat produces a pattern of neurodegeneration similar to that seen in Huntington's disease (HD). Although these changes have been related to transient motor abnormalities, the effects of chronic QA administration on cognitive abilities have not been ass...

journal_title：Experimental neurology

authors： Shear DA,Dong J,Haik-Creguer KL,Bazzett TJ,Albin RL,Dunbar GL

更新日期：1998-04-01 00:00:00

abstract：:Long-distance axon regeneration requires the activation of a specific set of neuronal growth-associated genes. Adult Purkinje cells fail to upregulate these molecules in response to axotomy and show extremely weak regenerative properties. Nevertheless, starting from several months after injury, transected Purkinje axo...

journal_title：Experimental neurology

authors： Gianola S,Rossi F

更新日期：2002-07-01 00:00:00

abstract：:Recent in vitro studies have shown that the periventricular subependymal zone (SEZ) of the rodent brain is capable of de novo generation of neurons and glia. There is less information available on neurogenesis in the adult human brain, and no study has shown the clonal generation of neurons and glia from in vitro-gene...

journal_title：Experimental neurology

authors： Kukekov VG,Laywell ED,Suslov O,Davies K,Scheffler B,Thomas LB,O'Brien TF,Kusakabe M,Steindler DA

更新日期：1999-04-01 00:00:00

abstract：:Peripheral nerve regeneration proceeds through a series of phases which include axonal sprouting, elongation, and maturation. Each phase requires interaction between intrinsic properties of the injured neuron and nonneural elements in the environment into which the nerve grows. It has been difficult, however, to separ...

journal_title：Experimental neurology

authors： Carlsen RC

更新日期：1983-10-01 00:00:00

abstract：:While past neuroimaging methods have contributed greatly to our understanding of brain function after traumatic brain injury (TBI), resting state functional MRI (rsfMRI) connectivity methods have more recently provided a far more unbiased approach with which to monitor brain circuitry compared to task-based approaches...

journal_title：Experimental neurology

authors： Harris NG,Verley DR,Gutman BA,Thompson PM,Yeh HJ,Brown JA

更新日期：2016-03-01 00:00:00

abstract：:There is evidence to suggest that the reticular activating system may have an influence on the neurons of the preoptic area (POA). We studied the responses of POA neurons and their relation to the cortical EEG, on stimulation of the midbrain reticular formation (MRF) at various frequencies, in unanesthetized, encéphal...

journal_title：Experimental neurology

authors： Mohan Kumar V,Mallick BN,Chhina GS,Singh B

更新日期：1984-10-01 00:00:00

abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...

journal_title：Experimental neurology

authors： Lurie DI,Selzer ME

更新日期：1991-04-01 00:00:00

abstract：:The role of nerve growth factor (NGF) was examined in the neural repair of adult rabbit facial nerves using an in vivo preparation. A 35-microliters nerve growth chamber was created by suturing the proximal and distal ends of a transected facial nerve (superior buccal branch) into a silicone tube. A gap of 8 mm in the...

journal_title：Experimental neurology

authors： Chen YS,Wang-Bennett LT,Coker NJ

更新日期：1989-01-01 00:00:00

abstract：:Green tea polyphenol is known to act as a buffer, reducing biological responses to oxidative stress. Several effects of polyphenol have been reported, such as protection of tissue from ischemia, antineoplasmic and anti-inflammatory effects, and suppression of arteriosclerosis. In this study, we investigated whether pe...

journal_title：Experimental neurology

authors： Ikeguchi R,Kakinoki R,Okamoto T,Matsumoto T,Hyon SH,Nakamura T

更新日期：2003-12-01 00:00:00

abstract：:Ischemic stroke (IS) is one of the most common cerebrovascular diseases worldwide. The aberrant expression of BCL6 has been previously implicated in the pathogenesis of IS. Meanwhile, miR-31 is known as a target of BCL6, and has also been suggested to diminish cell damage by suppressing the PKD1 expression. Expanding ...

journal_title：Experimental neurology

authors： Wei P,Chen H,Lin B,Du T,Liu G,He J,You C

更新日期：2021-01-01 00:00:00

abstract：:Abnormally associated movements inevitably occur after surgical repair of the facial nerve. The reason for this postparalytic syndrome is poor navigation of regrowing axons. Despite the valuable functional advantage provided by the easily detected movement of vibrissae in rats, the major investigative tools for establ...

journal_title：Experimental neurology

authors： Tomov TL,Guntinas-Lichius O,Grosheva M,Streppel M,Schraermeyer U,Neiss WF,Angelov DN

更新日期：2002-12-01 00:00:00

abstract：:l-DOPA therapy in Parkinson's disease often results in side effects such as l-DOPA-induced dyskinesia (LID). Our previous studies demonstrated that defective desensitization of dopamine receptors caused by decreased expression of G protein-coupled receptor kinases (GRKs) plays a role. Overexpression of GRK6, the isofo...

journal_title：Experimental neurology

authors： Ahmed MR,Bychkov E,Kook S,Zurkovsky L,Dalby KN,Gurevich EV

更新日期：2015-04-01 00:00:00

abstract：:Brain swelling is a serious complication associated with focal ischemia in stroke and severe head injury. Experimentally, reperfusion following focal cerebral ischemia exacerbates the level of brain swelling. In this study, the permeability of the blood-brain barrier has been investigated as a possible cause of reperf...

journal_title：Experimental neurology

authors： Gartshore G,Patterson J,Macrae IM

更新日期：1997-10-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:Electrical stimulation of the trigeminal ganglion has been widely used as a model of nociception, characterizing migraine. This treatment is known to evoke release of neuropeptides and neurotransmitters from nerve fibers of the dura mater. On the basis of immunocytochemical investigations, we found that under normal c...

journal_title：Experimental neurology

authors： Knyihár-Csillik E,Chadaide Z,Okuno E,Krisztin-Péva B,Toldi J,Varga C,Molnár A,Csillik B,Vécsei L

更新日期：2004-04-01 00:00:00

abstract：:Among the comorbidities observed in epilepsy patients depression is the most frequent one. Likewise, depression by itself is accompanied by an increased risk to develop epilepsy. Both epilepsy and depression are characterized by a high incidence of pharmacoresistance, which might be based on overactivity of multidrug ...

journal_title：Experimental neurology

authors： Klein S,Bankstahl JP,Löscher W,Bankstahl M

更新日期：2015-01-01 00:00:00

abstract：:Although zinc is essential for the activity of numerous biological systems, and zinc deficiency has been associated with various pathologies, this metal can also exert direct neurotoxic action. In primary cultures of rat cerebellar granule neurons, a brief, 15- to 30-min exposure to zinc (100-500 microM) resulted in c...

journal_title：Experimental neurology

authors： Manev H,Kharlamov E,Uz T,Mason RP,Cagnoli CM

更新日期：1997-07-01 00:00:00

abstract：:As in Alzheimer's disease, brains of Guam Chamorros with amyotrophic lateral sclerosis (ALS) and Parkinsonism-dementia complex (PDC) contain intraneuronal-paired helical filaments composed of accumulated phosphorylated tau protein. Tau mRNA expression in rat neuronal cultures-normally modulated by glutamate-increases ...

journal_title：Experimental neurology

authors： Esclaire F,Kisby G,Spencer P,Milne J,Lesort M,Hugon J

更新日期：1999-01-01 00:00:00

abstract：:Urethane-induced cortical slow wave activity (SWA) spreads into the basal ganglia in dopamine (DA)-depleted rat models of Parkinson's disease (PD). During physiological sleep, SWA is powerfully expressed at the beginning of night and progressively reduced during sleep-time reflecting the sleep need. However, its under...

journal_title：Experimental neurology

authors： Galati S,Song W,Orban G,Luft AR,Kaelin-Lang A

更新日期：2018-03-01 00:00:00

abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...

journal_title：Experimental neurology

authors： Weiss ML,Mitchell KE,Hix JE,Medicetty S,El-Zarkouny SZ,Grieger D,Troyer DL

更新日期：2003-08-01 00:00:00

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:Recent studies have shown that hemorrhagic injury in the preterm cerebellum leads to long-term neurological sequelae, such as motor, affective, and cognitive dysfunction. How cerebellar hemorrhage (CBH) affects the development and function of the cerebellum is largely unknown. Our study focuses on developing a mouse m...

journal_title：Experimental neurology

authors： Yoo JY,Mak GK,Goldowitz D

更新日期：2014-02-01 00:00:00

abstract：:Urotensin-II (U-II) is a cyclic peptide identified recently in many mammalian species including man. U-II and its receptor are expressed in the central nervous system, in the cardiovascular system and in other peripheral tissues. Although this peptide has been reported initially to be a potent vasoconstrictor, increas...

journal_title：Experimental neurology

authors： Chuquet J,Lecrux C,Chatenet D,Leprince J,Chazalviel L,Roussel S,MacKenzie ET,Vaudry H,Touzani O

更新日期：2008-04-01 00:00:00

abstract：:Paired corticospinal-motoneuronal stimulation (PCMS) elicits spinal synaptic plasticity in humans with chronic incomplete cervical spinal cord injury (SCI). Here, we examined whether PCMS-induced plasticity could be potentiated by acute intermittent hypoxia (AIH), a treatment also known to induce spinal synaptic plast...

journal_title：Experimental neurology

authors： Christiansen L,Chen B,Lei Y,Urbin MA,Richardson MSA,Oudega M,Sandhu M,Rymer WZ,Trumbower RD,Mitchell GS,Perez MA

更新日期：2021-01-01 00:00:00

abstract：:Adrenergic-stimulated phosphatidylinositol (PI) hydrolysis was measured in cortical slices obtained from adult rats following electroconvulsive seizures (ECS). One group of animals received ECS daily for 15 days and a second group received a single ECS. Rats were then sacrificed at intervals of 15 min, 60 min, 4 h, an...

journal_title：Experimental neurology

authors： Dubeau F,Sherwin AL

更新日期：1989-08-01 00:00:00