Influence of ascending reticular activating system on preoptic neuronal activity.

abstract：:Changes in the sleep pattern were investigated in rats given actinomycin S3 (AcS3, 0.25 mg/kg, intraventricularly), an inhibitor of RNA synthesis, at 0000, 0600, 1200, and 1800. The amounts of slow-wave (SS) and paradoxical sleep (PS) were increased during the dark period (1800 to 0600) in the groups treated at 0000, ...

journal_title：Experimental neurology

authors： Uezu E

更新日期：1983-08-01 00:00:00

abstract：:In the intraluminal suture model of middle cerebral artery occlusion (MCAO) in the rat, lesions of the masticator muscles associated with impaired functional outcome occur. We evaluated the role of external carotid artery (ECA) transection. We assessed whether isolated interruption of an arterial or a venous connectio...

journal_title：Experimental neurology

authors： Dittmar MS,Vatankhah B,Fehm NP,Retzl G,Schuierer G,Bogdahn U,Schlachetzki F,Horn M

更新日期：2005-10-01 00:00:00

abstract：:In order to study the ocular dominance and responsiveness of cells in the deafferented visual cortex, the geniculate and the callosal inputs were interrupted in adult cats by either simultaneous (OTCCX) or separate surgical transection of the optic tract (OTX) and the posterior corpus callosum (CCX). Unit recording wa...

journal_title：Experimental neurology

authors： Yinon U,Achiron A

更新日期：1988-03-01 00:00:00

abstract：:Using an approach that combines gene therapy with aromatic l-amino acid decarboxylase (AADC) gene and a pro-drug (l-dopa), dopamine, the neurotransmitter involved in Parkinson's disease, can be synthesized and regulated. Striatal neurons infected with the AADC gene by an adeno-associated viral vector can convert perip...

journal_title：Experimental neurology

authors： Bankiewicz KS,Eberling JL,Kohutnicka M,Jagust W,Pivirotto P,Bringas J,Cunningham J,Budinger TF,Harvey-White J

更新日期：2000-07-01 00:00:00

abstract：:Convection-enhanced delivery (CED) distributes macromolecules in the brain in a homogeneous, targeted fashion in clinically useful volumes. However, the binding of growth factors to heparin-binding sites in the extracellular matrix may limit the volume of distribution (V(d)). To overcome this limitation, we examined t...

journal_title：Experimental neurology

authors： Hamilton JF,Morrison PF,Chen MY,Harvey-White J,Pernaute RS,Phillips H,Oldfield E,Bankiewicz KS

更新日期：2001-03-01 00:00:00

abstract：:This study reevaluated the possibility of using predegenerated nerves as donor nerve allografts for nerve repair and compared the results of functional recovery to those obtained after standard, fresh nerve allograft repair. Twenty donor rats underwent a ligature/ section of the left sciatic nerve 4 weeks before nerve...

journal_title：Experimental neurology

authors： Dubuisson AS,Foidart-Dessalle M,Reznik M,Grosdent JC,Stevenaert A

更新日期：1997-11-01 00:00:00

abstract：:Previously injured dorsal roots were electrically stimulated to determine if regenerating sensory axons can form physiologically active synaptic contacts with neurons within fetal spinal cord tissue transplants. Dorsal rootlets, sectioned at their spinal cord entry zone, were apposed to intraspinal transplants of feta...

journal_title：Experimental neurology

authors： Houle JD,Skinner RD,Garcia-Rill E,Turner KL

更新日期：1996-06-01 00:00:00

abstract：:Granule cell (GC) neurogenesis increases following seizures, and some newborn GCs develop in abnormal locations within the hilus. These ectopic GCs (EGCs) display robust spontaneous and evoked excitatory activity. However, the pattern of afferent input they receive has not been fully defined. This study used electron ...

journal_title：Experimental neurology

authors： Pierce JP,Melton J,Punsoni M,McCloskey DP,Scharfman HE

更新日期：2005-12-01 00:00:00

abstract：:The anatomical distribution and the content of dendrite bundles were studied in the spinal cord of adult rats. We injected retrogradely transported Cholera Toxin subunit B into muscles in order to label motoneurons and their dendrites. Twenty-one muscles in the trunk and in extremities were selected which are involved...

journal_title：Experimental neurology

authors： Gramsbergen A,Ijkema-Paassen J,Westerga J,Geisler HC

更新日期：1996-01-01 00:00:00

abstract：:Hippocampal transplants were examined for the expression of three specific immediate early gene encoded proteins in order to establish if grafted immature tissue maintains the basic molecular program necessary for gene transcription after grafting to excitotoxic (ibotenic acid-induced) lesions in adult host rat brains...

journal_title：Experimental neurology

authors： Aznar S,Tønder N,Bele S,Kiessling M,Zimmer J,Gass P

更新日期：1995-12-01 00:00:00

abstract：:Global cerebral ischemia depletes brain tissue NAD+, an essential cofactor for mitochondrial and cellular metabolism, leading to bioenergetics failure and cell death. The post-ischemic NAD+ levels can be replenished by the administration of nicotinamide mononucleotide (NMN), which serves as a precursor for NAD+ synthe...

journal_title：Experimental neurology

authors： Klimova N,Fearnow A,Long A,Kristian T

更新日期：2020-03-01 00:00:00

abstract：:Traumatic axonal injury (TAI) evolves within minutes to hours following traumatic brain injury (TBI). Previous studies have identified axolemmal disruption and impaired axonal transport (AxT) as key mechanisms in the evolution of TAI. While initially hypothesized that axolemmal disruption culminates in impaired AxT, p...

journal_title：Experimental neurology

authors： Stone JR,Okonkwo DO,Dialo AO,Rubin DG,Mutlu LK,Povlishock JT,Helm GA

更新日期：2004-11-01 00:00:00

abstract：:The left external auditory meatus was removed in 4-day-old CBA/J mice; after killing at 45 days, serial sections of the cochleae and brain stem were prepared. From these, the cross-sectional areas of spiral ganglion neurons and of 14 auditory brain stem neuronal types were measured, using a total of 210 neurons of eac...

journal_title：Experimental neurology

authors： Webster DB

更新日期：1983-01-01 00:00:00

abstract：:Spinal axons in the larval sea lamprey regenerate following a complete spinal transection. It is not known whether regenerating growth cones require contact with cellular elements or whether the basement membrane and collagenous meninx primitiva which surround the spinal cord are sufficient for neurite out-growth. To ...

journal_title：Experimental neurology

authors： Lurie DI,Selzer ME

更新日期：1991-04-01 00:00:00

abstract：:The perirhinal cortex (PRh) has been suggested as a substrate for the expression of generalized clonic seizures in the late stages of kindling development (stages 4-5). Using the induction of Fos as a marker of neuronal activation, the PRh region was investigated after kindling or nonkindling electrical stimulation. N...

journal_title：Experimental neurology

authors： Ferland RJ,Nierenberg J,Applegate CD

更新日期：1998-05-01 00:00:00

abstract：:We recently described an experimental model of spinal cord contusive injury in the rat in which a modified weight-drop apparatus is used to generate reproducible mild, moderate, or severe final functional deficit. We now report several inexpensive alternatives for portions of the original apparatus which allow the pro...

journal_title：Experimental neurology

authors： Noble LJ,Wrathall JR

更新日期：1987-02-01 00:00:00

abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...

journal_title：Experimental neurology

authors： Zambenedetti P,Giordano R,Zatta P

更新日期：1998-09-01 00:00:00

abstract：:The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. D...

journal_title：Experimental neurology

authors： Andreassen OA,Dedeoglu A,Friedlich A,Ferrante KL,Hughes D,Szabo C,Beal MF

更新日期：2001-04-01 00:00:00

abstract：:With the use of four independent cell markers and Brd-U birthdating we have charted the earliest stages of neuronal differentiation and migration in the developing rat central nervous system, including the cortex, spinal cord, and retina. One of the markers, the monoclonal antibody 2G12, labeled a large subpopulation ...

journal_title：Experimental neurology

authors： Brittis PA,Meiri K,Dent E,Silver J

更新日期：1995-07-01 00:00:00

abstract：:Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis...

journal_title：Experimental neurology

authors： Scavone JL,Asan E,Van Bockstaele EJ

更新日期：2011-06-01 00:00:00

abstract：:Status epilepticus (SE) is an acute event, characterized by repeated or continuous seizures, which alters neuronal properties of the brain and can promote the epileptic disorder. Experimental observations indicate that SE becomes progressively less responsive to anti-epileptic drugs, suggesting changes in the underlyi...

journal_title：Experimental neurology

authors： Karunakaran S,Grasse DW,Moxon KA

更新日期：2012-04-01 00:00:00

abstract：:Hamsters were inoculated intracerebrally with the agent of transmissible mink encephalopathy and developed clerical signs of encephalopathy. Photoreceptor degeneration occurred in all animals examined histologically. The changes were similar to those in scrapie, although less extensive. The findings suggest that eithe...

journal_title：Experimental neurology

authors： Buyukmihci NC,Goehring-Harmon F,Marsh RF

更新日期：1987-06-01 00:00:00

abstract：:Intrastriatal injection of excitatory amino acids, particularly quinolinic acid, has been proposed as an animal model of Huntington's disease. Such neurotoxic lesions of caudate-putamen result in marked dopamine type-1 (D1) receptor losses in the injected nuclei as well as in the ipsilateral substantia nigra pars reti...

journal_title：Experimental neurology

authors： Filloux F,Wagster MV,Folstein S,Price DL,Hedreen JC,Dawson TM,Wamsley JK

更新日期：1990-11-01 00:00:00

abstract：:Brain swelling is a serious complication associated with focal ischemia in stroke and severe head injury. Experimentally, reperfusion following focal cerebral ischemia exacerbates the level of brain swelling. In this study, the permeability of the blood-brain barrier has been investigated as a possible cause of reperf...

journal_title：Experimental neurology

authors： Gartshore G,Patterson J,Macrae IM

更新日期：1997-10-01 00:00:00

abstract：:Axonal injury is present in essentially all clinically significant cases of traumatic brain injury (TBI). While no effective treatment has been identified to date, experimental TBI models have shown promising axonal protection using immunosuppressants FK506 and Cyclosporine-A, with treatment benefits attributed to cal...

journal_title：Experimental neurology

authors： Reeves TM,Trimmer PA,Colley BS,Phillips LL

更新日期：2016-09-01 00:00:00

abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...

journal_title：Experimental neurology

authors： Patel JR,Brewer GJ

更新日期：2008-09-01 00:00:00

abstract：:In a model of Parkinson's disease (PD), amphetamine, a dopamine (DA)-releasing drug, fails to induce ipsilateral drug rotations in a proportion of rats with complete unilateral 6-hydroxydopamine (6-OHDA) lesions of the medial forebrain bundle and DA neurons of the substantia nigra. To investigate this phenomenon, indi...

journal_title：Experimental neurology

authors： Moore AE,Cicchetti F,Hennen J,Isacson O

更新日期：2001-12-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:Oscillatory activity has been well-studied in many structures within cortico-basal ganglia circuits, but it is not well understood within the pedunculopontine nucleus (PPN), which was recently introduced as a potential target for the treatment of gait and postural impairments in advanced stages of Parkinson's disease ...

journal_title：Experimental neurology

authors： Li M,Zhou M,Wen P,Wang Q,Yang Y,Xiao H,Xie Z,Li X,Wang N,Wang J,Luo F,Chang J,Zhang W

更新日期：2016-08-01 00:00:00