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Effects of an inhibitor of poly(ADP-ribose) polymerase, desmethylselegiline, trientine, and lipoic acid in transgenic ALS mice.

Abstract：

:The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. Desmethylselegiline and CGP3466 are agents that exert antiapoptotic effects in vitro by preventing nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase. They had no significant effects on survival in the G93A mice. Trientine, a copper chelator, produced a modest significant increase in survival. Similarly administration of lipoic acid in the diet produced a significant improvement in survival. These results therefore provide evidence for potential therapeutic effects of copper chelators and lipoic acid in the treatment of ALS.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Andreassen OA,Dedeoglu A,Friedlich A,Ferrante KL,Hughes D,Szabo C,Beal MF

doi

10.1006/exnr.2001.7633

keywords:

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

419-24

issue

2

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(01)97633-2

journal_volume

168

pub_type

杂志文章

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