An inexpensive apparatus for producing graded spinal cord contusive injury in the rat.

abstract：:Intercostal muscle tendon organs have an inhibitory effect on the medullary neurons driving all inspiratory muscles, and on a subpopulation of medullary bulbospinal expiratory neurons. Results from this study showed that the activity of expiratory related neurons in the region of the retrofacial nucleus (Botzinger com...

journal_title：Experimental neurology

authors： Shannon R,Lindsey BG

更新日期：1987-09-01 00:00:00

abstract：:Phenytoin is known to reduce neural overactivity (pseudomyotonia) affecting the hind limb musculature in C57B1/6J dystrophic (dy2J/dy2J) mice. This study reports a change in the metabolic profile of superficial gastrocnemius muscle fibers from dy2J/dy2J animals after chronic phenytoin treatment. The superficial gastro...

journal_title：Experimental neurology

authors： Younger LE,Silverman H

更新日期：1984-04-01 00:00:00

abstract：:The review outlines data consistent with the hypothesis that inspiratory drive transmission that generates fetal breathing movements (FBMs) is essential for the developmental plasticity of phrenic motoneurons (PMNs) and diaphragm musculature prior to birth. A systematic examination during the perinatal period demonstr...

journal_title：Experimental neurology

authors： Greer JJ,Martin-Caraballo M

更新日期：2017-01-01 00:00:00

abstract：:A comparison of regenerated and normal frog sciatic nerves showed a marked reduction in conduction velocity from 37.5 to 15.2 m/s with little change in the absolute refractory period. Changes in conduction velocity corresponded to a reduced mean axon caliber (4.8 versus 6.6 micron). Regenerated nerves also had markedl...

journal_title：Experimental neurology

authors： Minwegen P,Friede RL

更新日期：1985-01-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

journal_title：Experimental neurology

authors： Parameshwaran K,Dhanasekaran M,Suppiramaniam V

更新日期：2008-03-01 00:00:00

abstract：:Ethanol exposure profoundly affects learning and memory and neural plasticity. Key players underlying these functions are neurotrophins. The present study explored the effects of ethanol on the distribution of neurotrophins in the cerebral cortex of the adult rat. Age- and weight-matched pairs of adult male, Long-Evan...

journal_title：Experimental neurology

authors： Bruns MB,Miller MW

更新日期：2007-04-01 00:00:00

abstract：:For most individuals, the respiratory control system produces a remarkably stable and coordinated motor output-recognizable as a breath-from birth until death. Very little is understood regarding the processes by which the respiratory control system maintains network stability in the presence of changing physiological...

journal_title：Experimental neurology

authors： Braegelmann KM,Streeter KA,Fields DP,Baker TL

更新日期：2017-01-01 00:00:00

abstract：:Cyclic nucleotides are thought to act as second messengers of neurotransmission inside central neurons, and cyclic guanosine monophosphate (cGMP) has been postulated to act as a messenger for muscarinic, cholinergic transmission. Nonetheless, the action of cGMP has not yet been established in identified cortical neuro...

journal_title：Experimental neurology

authors： Woody C,Gruen E,Sakai H,Sakai M,Swartz B

更新日期：1986-03-01 00:00:00

abstract：:To determine if phenytoin reduces depolarization-linked acetylcholine release from synaptosomes solely by interacting with Na+, the effect of phenytoin (100 to 200 microM) and/or tetrodotoxin (1 microM) on ACh release was assayed in synaptosomes depolarized with either KCl 56 mM or veratridine 10 microM. Phenytoin red...

journal_title：Experimental neurology

authors： Pincus JH,Kiss A

更新日期：1986-12-01 00:00:00

abstract：:Autonomic dysreflexia is a condition of episodic hypertension that develops after spinal cord injury (SCI). We previously showed that a two-day anti-inflammatory treatment with an anti-CD11d integrin monoclonal antibody (mAb), soon after SCI in rats, reduced the magnitude of dysreflexia for at least 6 weeks. Effects o...

journal_title：Experimental neurology

authors： Gris D,Marsh DR,Dekaban GA,Weaver LC

更新日期：2005-08-01 00:00:00

abstract：:Cervical spinal cord injury leads to a disruption of bulbospinal innervation from medullary respiratory centers to phrenic motoneurons. Animal models utilizing cervical hemisection result in inhibition of ipsilateral phrenic nerve activity, leading to paralysis of the hemidiaphragm. We have previously demonstrated a r...

journal_title：Experimental neurology

authors： Basura GJ,Zhou SY,Walker PD,Goshgarian HG

更新日期：2001-06-01 00:00:00

abstract：:Dopaminergic (DAergic) hypofunction in the medial prefrontal cortex (mPFC) has been implicated in the negative and cognitive symptoms of schizophrenia and is regulated by serotonergic (5-HTergic) neurons in the dorsal raphe nucleus (DRN). The lateral habenula (LHb) is a key element in controlling DRN 5-HT neurons. We ...

journal_title：Experimental neurology

authors： Li J,Yang S,Liu X,Han Y,Li Y,Feng J,Zhao H

更新日期：2019-08-01 00:00:00

abstract：:Microglia were described by Pio del Rio-Hortega (1932) as being the 'third element' distinct from neurons and astrocytes. Decades after this observation, the function and even the very existence of microglia as a distinct cell type were topics of intense debate and conjecture. However, considerable advances have been ...

journal_title：Experimental neurology

authors： Trang T,Beggs S,Salter MW

更新日期：2012-04-01 00:00:00

abstract：:Chronically axotomized motoneurons progressively fail to regenerate their axons. Since axonal regeneration is associated with the increased expression of tubulin, actin and GAP-43, we examined whether the regenerative failure is due to failure of chronically axotomized motoneurons to express and sustain the expression...

journal_title：Experimental neurology

authors： Gordon T,You S,Cassar SL,Tetzlaff W

更新日期：2015-02-01 00:00:00

abstract：:Muscular dystrophies (MDs) consist of a genetically heterogeneous group of disorders, recessive or dominant, characterized by progressive skeletal muscle weakening. To date, no effective treatment is available. Experimental strategies pursuing muscle regeneration through the transplantation of stem cell preparations h...

journal_title：Experimental neurology

authors： Darabi R,Baik J,Clee M,Kyba M,Tupler R,Perlingeiro RC

更新日期：2009-11-01 00:00:00

abstract：:Demyelinating diseases comprise a spectrum of immunopathologic syndromes in which myelin, the fatty covering of nerve cell fibers in the brain and spinal cord, is destroyed. In this study, we have shown for the first time that ocular infection of BALB/c mice with a recombinant herpes simplex virus type 1 (HSV-1) expre...

journal_title：Experimental neurology

authors： Osorio Y,La Point SF,Nusinowitz S,Hofman FM,Ghiasi H

更新日期：2005-05-01 00:00:00

abstract：:A 168-nucleotide exon, found in alternatively spliced amyloid precursor protein (APP) mRNAs, encodes a Kunitz protease inhibitor (KPI) domain. Kainic acid (ip) caused a selective increase of KPI mRNA in rat hippocampus. By in situ hybridization, KPI mRNA was induced in the neuronal layers of the hippocampus 11-12 h af...

journal_title：Experimental neurology

authors： Willoughby DA,Johnson SA,Pasinetti GM,Tocco G,Najm I,Baudry M,Finch CE

更新日期：1992-12-01 00:00:00

abstract：:Alcohol intake is one of the important lifestyle factors for the risk of insulin resistance and type 2 diabetes. Acetaldehyde, the major ethanol metabolite which is far more reactive than ethanol, has been postulated to participate in alcohol-induced tissue injury although its direct impact on insulin signaling is unc...

journal_title：Experimental neurology

authors： Fang CX,Yang X,Sreejayan N,Ren J

更新日期：2007-01-01 00:00:00

abstract：:Hypernatremic dehydration was induced in rabbits during a 3- to 5-day period resulting in mean plasma sodium concentrations of 187 meq/liter. The animals were then rehydrated during a 4-h period by intravenous administration of a 2.5% glucose or fructose solution. The water content of four regions of brain sample show...

journal_title：Experimental neurology

authors： Hogan GR,Pickering LK,Dodge PR,Shepard JB,Master S

更新日期：1985-02-01 00:00:00

abstract：:Two neutral alpha-glucosidase isoenzymes were isolated from the muscle of Japanese quails with late-onset acid maltase deficiency. One isoenzyme is predominantly expressed in embryonic muscle and the other in adult muscle. The time of switching from one to the other of these two neutral alpha-glucosidases was the same...

journal_title：Experimental neurology

authors： Usuki F,Ishiura S,Higuchi I,Sugita H

更新日期：1988-05-01 00:00:00

abstract：:Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

journal_title：Experimental neurology

authors： Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

更新日期：2010-03-01 00:00:00

abstract：:Thyroid hormones and spermidine, a motor neuron trophic polyamine (PA), have been shown to enhance peripheral motor nerve regeneration; however, the mechanism by which these treatment modalities exert their effect is unknown. Similarities in treatment outcome suggest that these molecules may be working via a common me...

journal_title：Experimental neurology

authors： Oble DA,Burton L,Maxwell K,Hassard T,Nathaniel EJ

更新日期：2004-09-01 00:00:00

abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

journal_title：Experimental neurology

authors： Rose DF,Eswaran H

更新日期：2004-11-01 00:00:00

abstract：:c-fos expression in response to noxious mechanical stimulation of the peripheral receptive field was used to study the somatotopic representation of the oral mucous membrane and trigeminal cutaneous receptive fields in the trigeminal subnucleus caudalis and the cervical spinal dorsal horn. Fos-neurons (neurons with c-...

journal_title：Experimental neurology

authors： Sugimoto T,Hara T,Shirai H,Abe T,Ichikawa H,Sato T

更新日期：1994-10-01 00:00:00

abstract：:Massive increases in extracellular dopamine have been reported in the ischemic rodent striatum, implicating this neurotransmitter in toxic events. We have examined whether dopamine receptor antagonists are protective against hypoxic insult, using brain slices containing the rostral striatum obtained from adult male C5...

journal_title：Experimental neurology

authors： Davis S,Brotchie J,Davies I

更新日期：2002-07-01 00:00:00

abstract：:Total, Mg2+-, Na+,K+-, and Ca2+-ATPase activities were studied in fresh brain membrane preparations from adult epileptic (El) mice and nonepileptic C57BL/6J (B6) mice. The El mice have an inherited type of temporal lobe epilepsy. No significant differences were observed between the El and B6 mice for any of the ATPase...

journal_title：Experimental neurology

authors： Palayoor ST,Seyfried TN

更新日期：1988-03-01 00:00:00

abstract：:Russian knapweed is a perennial weed found in many parts of the world, including southern California. Chronic ingestion of this plant by horses has been reported to cause equine nigropallidal encephalomalacia (ENE), which is associated with a movement disorder simulating Parkinson's disease (PD). Repin, a principal in...

journal_title：Experimental neurology

authors： Robles M,Choi BH,Han B,Santa Cruz K,Kim RC

更新日期：1998-07-01 00:00:00

abstract：:Monosialoganglioside GM1 prevents excitatory amino acid (EAA)-related neuronal death in cultured central nervous system (CNS) neurons and reduces the severity of acute brain damage in different experimental models of cerebral ischemia. Using a model of brain damage induced by intracerebroventricular administration of ...

journal_title：Experimental neurology

authors： Lipartiti M,Lazzaro A,Zanoni R,Mazzari S,Toffano G,Leon A

更新日期：1991-09-01 00:00:00

abstract：:For the past 15 years, patients with Parkinson's disease have participated in clinical trials evaluating the efficacy of intrastriatal dopamine transplants. Principally, two donor tissues have been employed, the chromaffin cells of the adrenal medulla and fetal ventral mesencephalon. The clinical response following ea...

journal_title：Experimental neurology

authors： Kordower JH,Goetz CG,Freeman TB,Olanow CW

更新日期：1997-03-01 00:00:00

abstract：:Biochemical, physiological, and anatomical studies over the past 30 years have firmly established glutamate (Glu) as the major neurotransmitter of those cortical neurons which give rise to corticofugal pathways. In the present study we utilized immunohistochemistry, with an antibody directed against Glu, in conjunctio...

journal_title：Experimental neurology

authors： Dinopoulos A,Dori I,Davies SW,Parnavelas JG

更新日期：1989-07-01 00:00:00