Abstract：
:The role of nerve growth factor (NGF) was examined in the neural repair of adult rabbit facial nerves using an in vivo preparation. A 35-microliters nerve growth chamber was created by suturing the proximal and distal ends of a transected facial nerve (superior buccal branch) into a silicone tube. A gap of 8 mm in the chamber remained after removal of a 5-mm piece of nerve and insertion of the proximal and distal stumps into the tube. Animals were operated bilaterally; one side of the chamber was filled with NGF and the contralateral side was filled with Ringer's solution. Regeneration of the nerves was examined 1 to 5 weeks following the surgery. The caliber of the nerve bundle, the distribution pattern of regenerating motoneurons, axon number per fascicle, size distribution, and the total number of cells were compared to the preoperative morphology pattern found for that animal. Each buccal branch served as its own control. The NGF-filled chambers demonstrated an overall larger caliber of nerve regeneration at 5 weeks and a higher density distribution of axon growth at 3 and 5 weeks. In the early regeneration case (3 weeks), the axon growth profile exhibited more fascicles and less axons than the preoperative controls. In the more advanced state (5 weeks), the fascicle number was reduced and the axon number was increased. After 5 weeks of regeneration the number of fascicles was still more than that found in the preoperative state. Axon size at 5 weeks was 80% that of the preoperative controls and the thickness of the myelin sheath was less than the preoperative level. The histogram of the size distribution revealed the same distribution as in the preoperative control section.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Chen YS,Wang-Bennett LT,Coker NJdoi
10.1016/0014-4886(89)90184-2subject
Has Abstractpub_date
1989-01-01 00:00:00pages
52-60issue
1eissn
0014-4886issn
1090-2430journal_volume
103pub_type
杂志文章abstract：:Neuregulins have been shown to play an important role in the development of the central nervous system, but their function in adult tissues is still unclear. We investigated the expression of the neuregulin receptors erbB3 and erbB4 in the adult rat brain by in situ hybridization histochemistry. Areas with considerabl...
journal_title：Experimental neurology
pub_type： 杂志文章
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abstract：:Nitrosative stress contributes to nerve conduction slowing, thermal hypoalgesia, and impaired nitrergic innervation in animal models of Type 1 diabetes. The role for reactive nitrogen species in Type 2 diabetes-associated neuropathy remains unexplored. This study evaluated the role for nitrosative stress in functional...
journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1984-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1997.6560
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7652
更新日期：2001-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1202
更新日期：1993-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2000.7576
更新日期：2001-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.05.013
更新日期：2013-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2015.03.004
更新日期：2015-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.8021
更新日期：2002-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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更新日期：2009-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2012-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1990-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1985-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1999-01-01 00:00:00
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journal_title：Experimental neurology
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更新日期：2005-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2012-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：1983-06-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2003-07-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7085
更新日期：1999-08-01 00:00:00
