Abstract:
:Noradrenergic input to the rat substantia innominata (SI) was analyzed in this study by immunocytochemical localization of dopamine beta-hydroxylase (DBH), the synthetic enzyme for noradrenaline. DBH immunoreactive (DBH+) axons ramified extensively within the SI and appeared to be contiguous with the DBH+ terminal fields within the bed nucleus of stria terminalis and the amygdaloid complex. DBH+ axons in the SI exhibited many large boutons en passant and boutons terminaux. These DBH+ boutons appeared much larger than those in the cerebral cortex, hippocampus, and thalamus. Electron microscopic analysis revealed that DBH+ boutons formed asymmetrical synapses with mainly dendrites, but also somata and spines of SI neurons. Dendrites which were postsynaptic to DBH+ boutons also formed synapses with many other unlabeled axon terminals. Since previous studies have shown that dendrites of SI cholinergic neurons formed few synapses, the present result suggests that the noradrenergic influence of SI cholinergic neurons may be mediated mainly by polysynaptic pathways.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Chang HTdoi
10.1016/s0014-4886(89)80002-0subject
Has Abstractpub_date
1989-05-01 00:00:00pages
101-12issue
2eissn
0014-4886issn
1090-2430pii
S0014-4886(89)80002-0journal_volume
104pub_type
杂志文章abstract::Neural stem cell (NSC) transplantation provides a new approach for the repair of damage to the central nervous system (CNS), including that resulting from cerebral infarction and spinal cord injury (SCI). In the past, there were no reputable means of converting non-neural somatic cells into neural cells. This status w...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2012.09.016
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.08.003
更新日期:2007-01-01 00:00:00
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journal_title:Experimental neurology
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更新日期:2009-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.05.019
更新日期:2008-09-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1993.1041
更新日期:1993-03-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1016/j.expneurol.2013.05.001
更新日期:2013-08-01 00:00:00
abstract::Theoretical and experimental analyses of deep brain stimulation (DBS) in the subthalamic nucleus (STN) show both excitatory and inhibitory effects on the neural elements surrounding the electrode. Given these observations, the mechanism underlying the therapeutic effect of STN DBS on parkinsonian motor signs remains u...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2008.01.032
更新日期:2008-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2004.12.004
更新日期:2005-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1996.0127
更新日期:1996-08-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1999.7272
更新日期:2000-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1994.1198
更新日期:1994-12-01 00:00:00
abstract::Excessive synchronization of neuronal activity at around 20 Hz is a common finding in the basal ganglia of patients with untreated Parkinson's disease (PD). Correlative evidence suggests, but does not prove, that this spontaneous activity may contribute to slowness of movement in this condition. Here we investigate wh...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2007.01.027
更新日期:2007-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2014.07.015
更新日期:2014-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(92)90191-r
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6509
更新日期:1997-07-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2003-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(91)90007-y
更新日期:1991-02-01 00:00:00
abstract::Regeneration in the peripheral nervous system offers unique opportunities and challenges to medicine. Compared to the central nervous system, peripheral axons can and do regenerate resulting in functional recovery, especially if the distance to target is short as in distal limb injuries. However, this regenerative cap...
journal_title:Experimental neurology
pub_type: 社论
doi:10.1016/j.expneurol.2009.12.001
更新日期:2010-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(85)90044-5
更新日期:1985-10-01 00:00:00
abstract::In vivo imaging of patients with Alzheimer's disease using positron emission tomography (PET) demonstrates progressive reductions in brain glucose metabolism and blood flow in relation to dementia severity, more so in association than primary cortical regions. These reductions likely follow regional synaptic loss or d...
journal_title:Experimental neurology
pub_type: 杂志文章,评审
doi:10.1006/exnr.1996.0180
更新日期:1996-11-01 00:00:00
abstract::A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6647
更新日期:1997-11-01 00:00:00
abstract::The retrograde axonal transport mechanism of motor neurons has been exploited to deliver the gene encoding Glial cell line-derived neurotrophic factor (GDNF) into the central nervous system to provide trophic support following injury. A nonviral gene delivery system, consisting of a monoclonal antibody (MC192) that bi...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/j.expneurol.2006.05.027
更新日期:2006-11-01 00:00:00
abstract::the antiexcitotoxic efficacy of melatonin, a putative endogenous hydroxyl radical scavenger, was studied in primary cultures of rat cerebellar granule neurons. Excitotoxicity was induced in 7- to 9-day-old cultures by an exposure to glutamate (15 min in the absence of magnesium) or to glutamate receptor agonists, kain...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(95)90005-5
更新日期:1995-01-01 00:00:00
abstract::Exogenously added gangliosides enhance sprouting, neurite outgrowth, and other neuronal activities; this effect may be initiated when a ganglioside binds to a membrane protein or when a ganglioside intercalates into the plasma membrane. To test whether binding to membrane proteins is sufficient for ganglioside-mediate...
journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.1997.6459
更新日期:1997-05-01 00:00:00