Mechanisms of decreased cholinergic arousal in focal seizures: In vivo whole-cell recordings from the pedunculopontine tegmental nucleus.

abstract：:Indirect epidemiological and experimental evidence suggest that the severity of injury during stroke is influenced by prior sleep history. The aim of our study was to test the effect of acute sleep deprivation on early outcome following experimental stroke. Young male Sprague-Dawley rats (n=20) were subjected to focal...

journal_title：Experimental neurology

authors： Moldovan M,Constantinescu AO,Balseanu A,Oprescu N,Zagrean L,Popa-Wagner A

更新日期：2010-03-01 00:00:00

abstract：:Ascending and descending spinal cord potentials were recorded during conduction block produced by compression and ischemia to the spinal cord of cats. Dorsally and ventrally applied compression produced proportional changes in both ascending and descending potentials. Results for induced ischemia were much more variab...

journal_title：Experimental neurology

authors： Bennett MH

更新日期：1983-06-01 00:00:00

abstract：:The glial cell-derived neurotrophic factor (GDNF) precursor contains several putative sites for prohormone convertase-mediated excision of short peptides. Here, we show that one of the predicted peptides, named BEP (brain excitatory peptide), induces a substantial increase in the synaptic excitability in rat CA1 pyram...

journal_title：Experimental neurology

authors： Immonen T,Alakuijala A,Hytönen M,Sainio K,Poteryaev D,Saarma M,Pasternack M,Sariola H

更新日期：2008-04-01 00:00:00

abstract：:Transforming growth factor-alpha (TGF-alpha), previously identified as a major member of the epidermal growth factor (EGF) family of growth factors, plays a role in proliferation, differentiation, and survival of neuronal and glial precursors and is implicated in development of the nervous system. However, its roles i...

journal_title：Experimental neurology

authors： Xian CJ,Li L,Deng YS,Zhao SP,Zhou XF

更新日期：2001-11-01 00:00:00

abstract：:Mesiotemporal lobe Epilepsy (MTLE), the most frequent form of focal epilepsy, is often drug-resistant. Enriching the epileptic focus with GABA-releasing engineered cells has been proposed as a strategy to prevent seizures. However, ex vivo data from animal models and MTLE patients suggest that, due to changes in chlor...

journal_title：Experimental neurology

authors： Stamboulian-Platel S,Legendre A,Chabrol T,Platel JC,Pernot F,Duveau V,Roucard C,Baudry M,Depaulis A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Intracerebral hemorrhage (ICH) is the common brain diseases in middle-aged and elderly people, with high disability and/or mortality rate, and is a serious public health concern. Both WNK3 kinase and the WNK3/SPAK/NKCC1 signaling pathway play an integral role in maintaining normal cell homeostasis. However, ...

journal_title：Experimental neurology

authors： Wu D,Lai N,Deng R,Liang T,Pan P,Yuan G,Li X,Li H,Shen H,Wang Z,Chen G

更新日期：2020-10-01 00:00:00

abstract：:A new method is presented for the quantification of cell viability based on densitometry with computerized image analysis. Neuronal cells were stained with crystal violet and densitometric analysis was performed with an IBAS 2.0 image analyzer (Kontron/ Zeiss), using specially implemented dedicated software which inte...

journal_title：Experimental neurology

authors： Andreoni G,Angeretti N,Lucca E,Forloni G

更新日期：1997-11-01 00:00:00

abstract：:A variety of growth factors are being explored as therapeutic agents relevant to the axonal and oligodendroglial deficits that occur as a result of demyelinating lesions such as are evident in Multiple Sclerosis (MS). This review focuses on five such proteins that are present in the lesion site and impact oligodendroc...

journal_title：Experimental neurology

authors： Huang Y,Dreyfus CF

更新日期：2016-09-01 00:00:00

abstract：:Targeting interhemispheric inhibition using brain stimulation has shown potential for enhancing stroke recovery. Following stroke, increased inhibition originating from the contralesional hemisphere impairs motor activation in ipsilesional areas. We have previously reported that low-intensity electrical theta burst st...

journal_title：Experimental neurology

authors： Boddington LJ,Gray JP,Schulz JM,Reynolds JNJ

更新日期：2020-01-01 00:00:00

abstract：:Using a measure of nonlinear dynamical changes we term marginal predictability, we report evidence of robust changes in this parameter on scalp EEG in a cohort of patients with medically refractory mesiobasal temporal lobe epilepsy (MBTLE). In the baseline (interictal) state there are distinct differences in this nonl...

journal_title：Experimental neurology

authors： Drury I,Smith B,Li D,Savit R

更新日期：2003-11-01 00:00:00

abstract：:Hippocampal transplants were examined for the expression of three specific immediate early gene encoded proteins in order to establish if grafted immature tissue maintains the basic molecular program necessary for gene transcription after grafting to excitotoxic (ibotenic acid-induced) lesions in adult host rat brains...

journal_title：Experimental neurology

authors： Aznar S,Tønder N,Bele S,Kiessling M,Zimmer J,Gass P

更新日期：1995-12-01 00:00:00

abstract：:The long-term effects of partial denervation on the muscle fiber cross-sectional area, degree of axonal sprouting, and end-plate morphology were examined 1, 3, 6, 9, and 12 months postsurgery in rat plantaris muscle. After 1 month of partial denervation, mean cross-sectional areas of type I and type II myofibers were ...

journal_title：Experimental neurology

authors： Pachter BR,Eberstein A

更新日期：1992-06-01 00:00:00

abstract：:Potassium and caffeine contractures of isolated small bundles (100 to 200 micron diameter) of muscle fibers isolated from the diaphragm of normal and dystrophic (C57BL/6J dy2J/dy2J) mice were compared. In diaphragms of pathologic mice (3 to 5 months old) the resting potential, the characteristics of the twitch, and so...

journal_title：Experimental neurology

authors： Noireaud J,Léoty C

更新日期：1984-03-01 00:00:00

abstract：:Following traumatic brain injury (TBI), mitochondrial function becomes compromised. Mitochondrial dysfunction is characterized by intra-mitochondrial Ca(2+) accumulation, induction of oxidative damage, and mitochondrial permeability transition (mPT). Experimental studies show that cyclosporin A (CsA) inhibits mPT. How...

journal_title：Experimental neurology

authors： Mbye LH,Singh IN,Sullivan PG,Springer JE,Hall ED

更新日期：2008-01-01 00:00:00

abstract：:The central histaminergic system is one of the subcortical aminergic projection systems involved in several regulatory functions. The central dopaminergic and histaminergic systems interact extensively, but little is known about the histaminergic system in diseases affecting the dopaminergic neurons. The distribution ...

journal_title：Experimental neurology

authors： Anichtchik OV,Rinne JO,Kalimo H,Panula P

更新日期：2000-05-01 00:00:00

abstract：:Temporomandibular disorders (TMDs) are orofacial pains within the trigeminal distribution, which involve the masticatory musculature, the temporomandibular joint or both. Their pathophysiology remains unclear, as inflammatory mediators are thought to be involved, and clinically TMD presents pain and sometimes limitati...

journal_title：Experimental neurology

authors： Romero-Reyes M,Pardi V,Akerman S

更新日期：2015-09-01 00:00:00

abstract：:HIV-associated neurocognitive disorders (HAND) continue to persist despite effective control of viral replication. Although the mechanisms underlying HAND are poorly understood, recent attention has focused on altered neuronal population activity as a correlate of impaired cognition. However, while alterations in neur...

journal_title：Experimental neurology

authors： Bozzelli PL,Caccavano A,Avdoshina V,Mocchetti I,Wu JY,Conant K

更新日期：2020-01-01 00:00:00

abstract：:The alpha-secretase-derived form of the amyloid precursor protein (sAPPalpha), which is released from neurons in an activity-dependent manner, has been shown to promote long-term survival of hippocampal and cortical neurons in culture and can protect those neurons against excitotoxic and ischemic injury in culture and...

journal_title：Experimental neurology

authors： Cheng G,Yu Z,Zhou D,Mattson MP

更新日期：2002-06-01 00:00:00

abstract：:Focal infarction (stroke) of the lateral cerebral cortex of rats (including the sensorimotor cortex) produces deficits in sensorimotor function of the contralateral limbs that recover partially over time. In previous studies, we found that the intracisternal injection of basic fibroblast growth factor (bFGF), a potent...

journal_title：Experimental neurology

authors： Kawamata T,Ren J,Cha JH,Finklestein SP

更新日期：1999-07-01 00:00:00

abstract：:Nerve injury frequently results in development of chronic, dysesthetic pain and allodynia (painful sensation in response to benign stimulation). Following nerve injury, spinal cord glia become activated and secrete a number of inflammatory cytokines, including interleukin-1 (IL-1), which exists as two genetically dist...

journal_title：Experimental neurology

authors： Skoff AM,Zhao C,Adler JE

更新日期：2009-06-01 00:00:00

abstract：:We compared the magnetic cerebral activity of 10 fetal subjects at two different gestational ages. Spontaneous cerebral activity was recorded with a large array magnetometer specially designed to conform to the maternal gravid abdomen during the third trimester of pregnancy. We recorded each fetal subject at least twi...

journal_title：Experimental neurology

authors： Rose DF,Eswaran H

更新日期：2004-11-01 00:00:00

abstract：:Respiratory motor output after cervical spinal cord injury (cSCI) is profoundly influenced by spinal serotonin. We hypothesized that intraspinal transplantation of embryonic midline brainstem (MB) cells rich in serotonergic raphé neurons would improve respiratory outcomes after cSCI. One week after hemisection of the ...

journal_title：Experimental neurology

authors： Dougherty BJ,Gonzalez-Rothi EJ,Lee KZ,Ross HH,Reier PJ,Fuller DD

更新日期：2016-04-01 00:00:00

abstract：:Microglia express cytokines, major histocompatibility (MHC) loci, and several other immunologically important constituents. The aim of this study was to detect immunological responses of microglial cells following allogeneic dopaminergic transplantation using active and adoptive immunizations. Adult inbred Fisher 344 ...

journal_title：Experimental neurology

authors： Shinoda M,Hudson JL,Strömberg I,Hoffer BJ,Moorhead JW,Olson L

更新日期：1996-10-01 00:00:00

abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...

journal_title：Experimental neurology

authors： Brook GA,Spitzer C,Nacimiento W,Kouchtir-Devanne N,Woodhams PL,Noth J

更新日期：1997-07-01 00:00:00

abstract：:Extracellular unit activity from 29 neurons in the preoptic area was recorded together with the cortical EEG in encéphale isolé cats. A majority (55%) of neurons showed alterations in their firing rates during transient changes in the EEG. Among them, a majority (62.5%) showed an increased firing rate during synchroni...

journal_title：Experimental neurology

authors： Mallick BN,Chhina GS,Sundaram KR,Singh B,Kumar VM

更新日期：1983-09-01 00:00:00

abstract：:The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's disease. We show here that when a clonal line (C17.2) of undifferentiated NSCs is transplanted into the intact or 6-hydroxydopamine-...

journal_title：Experimental neurology

authors： Yang M,Stull ND,Berk MA,Snyder EY,Iacovitti L

更新日期：2002-09-01 00:00:00

abstract：:Breathing is a life-sustaining behavior that in mammals is accomplished by activation of dedicated muscles responsible for inspiratory and expiratory forces acting on the lung and chest wall. Motor control is exerted by specialized pools of motoneurons in the medulla and spinal cord innervated by projections from mult...

journal_title：Experimental neurology

authors： Mantilla CB

更新日期：2017-01-01 00:00:00

abstract：:Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...

journal_title：Experimental neurology

authors： Levin J,Giese A,Boetzel K,Israel L,Högen T,Nübling G,Kretzschmar H,Lorenzl S

更新日期：2009-01-01 00:00:00

abstract：:While past neuroimaging methods have contributed greatly to our understanding of brain function after traumatic brain injury (TBI), resting state functional MRI (rsfMRI) connectivity methods have more recently provided a far more unbiased approach with which to monitor brain circuitry compared to task-based approaches...

journal_title：Experimental neurology

authors： Harris NG,Verley DR,Gutman BA,Thompson PM,Yeh HJ,Brown JA

更新日期：2016-03-01 00:00:00

abstract：:Chemokines are a family of structurally related cytokines that activate and recruit leukocytes into areas of inflammation. The "CC" chemokine, monocyte chemoattractant protein (MCP)-1 may regulate the microglia/monocyte response to acute brain injury. Recent studies have documented increased expression of MCP-1 in div...

journal_title：Experimental neurology

authors： Galasso JM,Miller MJ,Cowell RM,Harrison JK,Warren JS,Silverstein FS

更新日期：2000-10-01 00:00:00