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Desmoplakin is involved in organization of an adhesion complex in peripheral nerve regeneration after injury.

Abstract：

:Peripheral nerves have the unique capability to regenerate after injury. Insights into regeneration of peripheral nerves after injury may have implications for neurodegenerative diseases of the nervous system. In this study, we analyzed the expression and function of desmoplakin in peripheral nerve regeneration. Desmoplakin was upregulated in spinal cord motoneurons after sciatic nerve injury. Conditional ablation of desmoplakin in motoneurons demonstrated that desmoplakin is necessary for normal motor regeneration. SiRNA and desmoplakin deletion-constructs revealed a role of desmoplakin in neurite extension in vitro. A complex of N-cadherin, plakoglobin, desmoplakin and vimentin was shown in motoneuronal cell cultures and peripheral nerves after injury in vivo. Motor nerve fiber regeneration and localization of N-cadherin and vimentin to axonal growth fronts were reduced in conditionally desmoplakin-ablated mice. These data indicate a function of desmoplakin in motor nerve regeneration by linking N-cadherin to intermediate filaments in regenerating motor axons.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Gess B,Röhr D,Lange E,Halfter H,Young P

doi

10.1016/j.expneurol.2014.12.005

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

55-66

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(14)00390-2

journal_volume

264

pub_type

杂志文章

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