Abstract：
:Multiple sclerosis (MS), the most frequent inflammatory disease of the central nervous system (CNS), affects about two and a half million individuals worldwide and causes major burdens to the patients, which develop the disease usually at the age of 20 to 40. MS is likely referable to a breakdown of immune cell tolerance to CNS self-antigens resulting in focal immune cell infiltration, activation of microglia and astrocytes, demyelination and axonal and neuronal loss. Here we discuss how altered expression patterns and dysregulated functions of ion channels contribute on a molecular level to nearly all pathophysiological steps of the disease. In particular the detrimental redistribution of ion channels along axons, as well as neuronal excitotoxicity with regard to imbalanced glutamate homeostasis during chronic CNS inflammation will be discussed in detail. Together, we describe which ion channels in the immune and nervous system commend as attractive future drugable targets in MS treatment.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Schattling B,Eggert B,Friese MAdoi
10.1016/j.expneurol.2013.12.006subject
Has Abstractpub_date
2014-12-01 00:00:00pages
28-36eissn
0014-4886issn
1090-2430pii
S0014-4886(13)00372-5journal_volume
262 Pt Apub_type
杂志文章,评审abstract：:The receptiveness of the brain to monocyte infiltration was studied in rats that had been injected intracerebrally with Corynebacterium parvum. At 0-17 days after intracerebral injection and 18 h after intravenous injection of diI-labeled isogenous mononuclear cells, host rats were sacrificed and cells from the vicini...
journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2015-03-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7247
更新日期：2000-01-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.05.010
更新日期：2008-09-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90005-5
更新日期：1983-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90114-r
更新日期：1991-04-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90279-0
更新日期：1983-08-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(89)90121-0
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6886
更新日期：1998-10-01 00:00:00
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pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
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pub_type： 杂志文章
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更新日期：2013-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7302
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2013-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2011-12-01 00:00:00
abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...
journal_title：Experimental neurology
pub_type： 杂志文章
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更新日期：2003-08-01 00:00:00
