Direct intranigral administration of an ubiquitin proteasome system inhibitor in rat: behavior, positron emission tomography, immunohistochemistry.

abstract：:Adaptive responses in glutamate and opioid receptor systems in limbic circuits are emerging as a critical component of the neural plasticity induced by chronic use of abused substances. The present commentary reviews findings from neuroanatomical studies, with superior spatial resolution, that support a cellular basis...

journal_title：Experimental neurology

authors： Scavone JL,Asan E,Van Bockstaele EJ

更新日期：2011-06-01 00:00:00

abstract：:Bombesin/gastrin-releasing peptide (BB/GRP) receptors were characterized in fetal cortex transplants in the rat. Using in vitro autoradiography techniques, the density of (125I-Tyr4)BB grains was low 2 weeks after transplantation but increased 4 weeks after cortex transplantation into the adult rat fourth ventricle. D...

journal_title：Experimental neurology

authors： Moody TW,Getz R,Rosenstein JM

更新日期：1996-11-01 00:00:00

abstract：:The ability of insulin like growth factor 1 (IGF-1) to prevent the pathophysiology associated with amyotrophic lateral sclerosis (ALS) is currently being explored with animal models and in clinical trials with patients. Several studies have reported positive effects of IGF-1 in reducing motor neuron death, delaying th...

journal_title：Experimental neurology

authors： Messi ML,Clark HM,Prevette DM,Oppenheim RW,Delbono O

更新日期：2007-09-01 00:00:00

abstract：:The role of type IIA receptor protein tyrosine phosphatases (RPTPs), which includes LAR, RPTPσ and RPTPδ, in the nervous system is becoming increasingly recognized. Evidence supports a significant role for these RPTPs during the development of the nervous system as well as after injury, and mutations in RPTPs are asso...

journal_title：Experimental neurology

authors： Yi JH,Katagiri Y,Yu P,Lourie J,Bangayan NJ,Symes AJ,Geller HM

更新日期：2014-05-01 00:00:00

abstract：:Ciliary neurotrophic factor (CNTF) and brain-derived neurotrophic factor (BDNF) have been shown both in vitro and in vivo to support the survival and differentiation of developing chick or rat motoneurons. To explore the potential use of these and other neurotrophic factors as therapeutic agents in human motoneuron di...

journal_title：Experimental neurology

authors： Kato AC,Lindsay RM

更新日期：1994-12-01 00:00:00

abstract：:This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...

journal_title：Experimental neurology

authors： Bergman H,Prell GD,Lupica CR,Granholm AC

更新日期：1995-11-01 00:00:00

abstract：:Eph tyrosine kinase receptors and their ligands, the ephrins, play a key role in the establishment of retinotectal topography during development. Tectal up-regulation of ephrin-A2 in goldfish, coincident with the reestablishment of a retinotectal map, suggests a similar role during optic nerve regeneration. Here we re...

journal_title：Experimental neurology

authors： King CE,Wallace A,Rodger J,Bartlett C,Beazley LD,Dunlop SA

更新日期：2003-10-01 00:00:00

abstract：:RNA interference appears to have a great potential not only as an in vitro target validation, but also as a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. We hypothesize that MMP-9 siRNA can be effective as an MMP-9 protein inhibitor in a rat focal ischemia model. Mal...

journal_title：Experimental neurology

authors： Hu Q,Chen C,Yan J,Yang X,Shi X,Zhao J,Lei J,Yang L,Wang K,Chen L,Huang H,Han J,Zhang JH,Zhou C

更新日期：2009-03-01 00:00:00

abstract：:In this review we focus on Charcot-Marie-Tooth (CMT) neuropathies and hereditary spastic paraplegias (HSPs). Although these diseases differ in whether they primarily affect the peripheral or central nervous system, both are genetically determined, progressive, long axonopathies that affect motor and sensory pathways. ...

journal_title：Experimental neurology

authors： Timmerman V,Clowes VE,Reid E

更新日期：2013-08-01 00:00:00

abstract：:The recently discovered endocannabinoid system (ECS), which includes endocannabinoids and the proteins that metabolize and bind them, has been implicated in multiple regulatory functions both in health and disease. Several studies have suggested that ECS is centrally and peripherally involved in the processing of pain...

journal_title：Experimental neurology

authors： Greco R,Gasperi V,Maccarrone M,Tassorelli C

更新日期：2010-07-01 00:00:00

abstract：:SCI is followed by dramatic upregulation of chondroitin sulfate proteoglycans (CSPGs) which limit axonal regeneration, oligodendrocyte replacement and remyelination. The recent discovery of the specific CSPGs signaling receptor protein tyrosine phosphatase sigma (RPTPσ) provided an opportunity to refine the therapeuti...

journal_title：Experimental neurology

authors： Rink S,Arnold D,Wöhler A,Bendella H,Meyer C,Manthou M,Papamitsou T,Sarikcioglu L,Angelov DN

更新日期：2018-11-01 00:00:00

abstract：:The monoclonal antibody Py has previously been shown to be a useful marker for subpopulations of neurons in the rat brain. However, the distribution of Py immunoreactivity in other regions of the CNS and PNS is not known. Here, we present a light and electron microscopic investigation into the distribution of Py immun...

journal_title：Experimental neurology

authors： Brook GA,Spitzer C,Nacimiento W,Kouchtir-Devanne N,Woodhams PL,Noth J

更新日期：1997-07-01 00:00:00

abstract：:Despite the importance of the periaqueductal gray (PAG) in the modulation of nociception and pain, many aspects of the roles of the different columns of the PAG in descending controls: facilitation and inhibition, are not understood. Employing a tonic muscle pain model established by i.m. injection of 5.8% saline into...

journal_title：Experimental neurology

authors： Lei J,Sun T,Lumb BM,You HJ

更新日期：2014-07-01 00:00:00

abstract：:Breathing is a vital homeostatic behavior and must be precisely regulated throughout life. Clinical conditions commonly associated with inflammation, undermine respiratory function may involve plasticity in respiratory control circuits to compensate and maintain adequate ventilation. Alternatively, other clinical cond...

journal_title：Experimental neurology

authors： Hocker AD,Stokes JA,Powell FL,Huxtable AG

更新日期：2017-01-01 00:00:00

abstract：:Huntington's disease (HD) is an inherited progressive neurodegenerative disorder characterized by progressive movement, psychiatric and cognitive disturbances. Previous studies have indicated that HD pathogenesis may be mediated in part by loss of brain derived neurotrophic factor (BDNF). Antidepressants selectively b...

journal_title：Experimental neurology

authors： Peng Q,Masuda N,Jiang M,Li Q,Zhao M,Ross CA,Duan W

更新日期：2008-03-01 00:00:00

abstract：:The kindling phenomenon, i.e., the progressive development of focal and secondarily generalized seizures upon repeated electrical stimulation of a limbic brain region, occurs in various species, but with marked differences in kindling rate between species and also within the same species. In rats, differences in kindl...

journal_title：Experimental neurology

authors： Löscher W,Cramer S,Ebert U

更新日期：1998-12-01 00:00:00

abstract：:Mitochondria actively participate in neurotransmission by providing energy (ATP) and maintaining normative concentrations of reactive oxygen species (ROS) in both presynaptic and postsynaptic elements. In human and animal epilepsies, ATP-producing respiratory rates driven by mitochondrial respiratory complex (MRC) I a...

journal_title：Experimental neurology

authors： Simeone KA,Matthews SA,Samson KK,Simeone TA

更新日期：2014-01-01 00:00:00

abstract：:Amyotrophic lateral sclerosis [ALS] is a rapidly progressive neurodegenerative disorder of motor neurons, heralded by the development of cortical hyperexcitability. Reduction of short interval intracortical inhibition [SICI] in ALS, a feature linked to the development of cortical hyperexcitability, may be mediated by ...

journal_title：Experimental neurology

authors： Vucic S,Cheah BC,Kiernan MC

更新日期：2009-11-01 00:00:00

abstract：:Five female adult Macaca nemestrina monkeys, given a unilateral intracarotid (ic) infusion of 2.3-3.5 mg of MPTP-HCl, were studied for 6-8 years. Two to 3 days after MPTP, the animals developed hemiparkinsonism characterized by rigidity and flexed posture of the arm contralateral to the side of infusion with episodes ...

journal_title：Experimental neurology

authors： Emborg-Knott ME,Domino EF

更新日期：1998-08-01 00:00:00

abstract：:In this study, we show that removal of entorhinal cortex (ERC) afferents to hippocampus reduces levels of presenilin 1 (PS1) in the dentate gyrus of APPswe/PS1DeltaE9 transgenic (Tg) mice. PS1 immunoreactivity on the deafferented dentate gyrus decreases by approximately 25% and 50%, 2 and 4 weeks post-lesion compared ...

journal_title：Experimental neurology

authors： Sheng JG,Price DL,Koliatsos VE

更新日期：2003-12-01 00:00:00

abstract：:The effects of superior cervical ganglion stimulation and the local application of norepinephrine or its antagonist propranolol were studied in 18 pineal cells. In 61% of the pineal cells, stimulation elicited excitation; the same cells also responded by excitation to norepinephrine ejection. When stimulation and nore...

journal_title：Experimental neurology

authors： Reyes-Vazquez C,Dafny N

更新日期：1985-12-01 00:00:00

abstract：:To determine whether or not brain damage is likely to occur in the repeated apneic episodes experienced by some alcoholics during intoxicated sleep, rats were anesthetized with alcohol and subjected to repeated episodes to asphyxia. Each episode lasted 90 s, arterial PO2 was less than 50 mm Hg for 60 s, and 30 episode...

journal_title：Experimental neurology

authors： Cragg B,Phillips S

更新日期：1984-04-01 00:00:00

abstract：:The aim of the present study is to determine whether the expansion and mobilization of circulating bone marrow (BM) stem cells by in vivo treatment with granulocyte-colony stimulating factor (G-CSF) and stem cell factor (SCF) increase the amount of BM-derived neuronal cells in mouse brain. The presence of BM-derived c...

journal_title：Experimental neurology

authors： Corti S,Locatelli F,Strazzer S,Salani S,Del Bo R,Soligo D,Bossolasco P,Bresolin N,Scarlato G,Comi GP

更新日期：2002-10-01 00:00:00

abstract：:Exosomes secreted by microglia have been found to play a role in neurovascular unit injury under the ischemic/hypoxic state. However, the modulatory effect of exosomes shuttled miRNAs produced by microglia in endothelial cells remains undefined. Here, an oxygen-glucose deprivation (OGD) model was constructed both in m...

journal_title：Experimental neurology

authors： Xie L,Zhao H,Wang Y,Chen Z

更新日期：2020-11-01 00:00:00

abstract：:To compare the evolution of cell body responses to two different types of axonal injuries--sciatic nerve crush (axotomy) and chronic 2,5-hexanedione-induced neuropathy--we studied rat lumbar dorsal root ganglion neurons with light microscopy and morphometry. Compared with control neurons, axotomized cells showed early...

journal_title：Experimental neurology

authors： Sterman AB,Delannoy MR

更新日期：1985-08-01 00:00:00

abstract：:Ubiquitin (Ub) C-terminal hydrolase L1 (UCHL1) is a multifunctional protein that is expressed in neurons throughout brain at high levels. UCHL1 deletion is associated with axonal degeneration, progressive sensory motor ataxia, and premature death in mice. UCHL1 has been hypothesized to play a role in the pathogenesis ...

journal_title：Experimental neurology

authors： Mi Z,Liu H,Rose ME,Ma X,Reay DP,Ma J,Henchir J,Dixon CE,Graham SH

更新日期：2021-02-01 00:00:00

abstract：:An electron microscopic investigation of neuromuscular synapses of the tensor fasciae latae muscle in juvenile mice was carried out to determine the relationship between the presynaptic (nerve terminal) and postsynaptic (end-plate plaque) elements during the major phase of postnatal growth. In the first month of life ...

journal_title：Experimental neurology

authors： Habgood MD,Hopkins WG

更新日期：1987-05-01 00:00:00

abstract：:The regional cerebral blood flow of 27 young (mean age 24 years) schizophrenic patients was measured using the intravenous 133Xe method. The results were compared with those obtained from a group of age- and sex-matched control subjects. The main findings of the study were as follows: (a) the gray matter mean values o...

journal_title：Experimental neurology

authors： Dousse M,Mamo H,Ponsin JC,Tran Dinh Y

更新日期：1988-04-01 00:00:00

abstract：:In vivo studies have shown that high blood concentrations of pituitary-adrenocortical hormones can activate the hippocampal cholinergic terminals. Incubation of hippocampal synaptosomal preparations with methylprednisolone, or with ACTH at concentrations comparable to stress-induced high concentrations in plasma, did ...

journal_title：Experimental neurology

authors： Finkelstein Y,Sternfeld M,Yegana Y,Ben-Menahem N,Flechter S,Hod I

更新日期：1987-10-01 00:00:00

abstract：:Activity-dependent alteration in synaptic efficacy is referred to as synaptic plasticity and is the believed hallmark of any learning process. Here we employed a recently validated complex maze for spatial training and investigated the impact of repeated and extensive training on basal synaptic transmission of the hip...

journal_title：Experimental neurology

authors： Lange-Asschenfeldt C,Lohmann P,Riepe MW

更新日期：2007-02-01 00:00:00