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Despite the internucleosomal cleavage of DNA, reactive oxygen species do not produce other markers of apoptosis in cultured neurons.

Abstract：

:The cell death induced by hydroxyl radicals generated by Cu-phenanthroline and peroxynitrite generated by 3-morpholinosydnonimine hydrochloride (SIN-1) in rat primary cortical neuronal cultures was compared with the apoptotic death induced by staurosporine and the necrotic death induced by glutamate. Both SIN-1 and Cu-phenanthroline were capable of generating internucleosomal cleavage of DNA-a hallmark of apoptosis. Other characteristics of this cell death, such as nuclear morphology by light microscopy; DNA breaks by single-cell gel electrophoresis; the effects of the apoptotic inhibitors cycloheximide, aurintricarboxylic acid, and tosyl-l-lysine chloromethyl ketone; the measurement of caspase activity; and the effects of antioxidants, were then analyzed. The conclusion from these hallmarks of apoptosis is that the cell death induced by these reactive oxygen species is not apoptosis.

journal_name

Exp Neurol

journal_title

Experimental neurology

authors

Hill IE,Murray C,Richard J,Rasquinha I,MacManus JP

doi

10.1006/exnr.2000.7322

keywords:

subject

Has Abstract

pub_date

2000-03-01 00:00:00

pages

73-88

issue

1

eissn

0014-4886

issn

1090-2430

pii

S0014-4886(00)97322-9

journal_volume

162

pub_type

杂志文章

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