Abstract：
:GAP-43 is a neuronal protein whose synthesis is elevated during developmental and regenerative axon growth. We propose that one consequence of this increased synthesis may be the delivery of calmodulin-like proteins to the distal portions of the growing axon at an increased velocity; this is because calmodulin, which is transported slowly in mature intact axons, can bind to GAP-43, which is transported rapidly. The release of calmodulin from GAP-43 would be regulated by phosphorylation by protein kinase C. Such a rapid carrier function could be important for allowing certain recently synthesized slowly transported proteins to reach the moving growth cone in time to support its function. This hypothetical carrier mechanism is consistent with the phosphorylation pattern, calmodulin binding, transport velocity, and growth-association of GAP-43, and suggests an explanation for the specific importance of newly synthesized GAP-43 in supporting axon growth.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Spencer S,Willard MBdoi
10.1016/0014-4886(92)90243-jkeywords:
subject
Has Abstractpub_date
1992-01-01 00:00:00pages
167-72issue
1eissn
0014-4886issn
1090-2430pii
0014-4886(92)90243-Jjournal_volume
115pub_type
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