Abstract:
:This study examined the effect of experimental diabetes on the anterograde and retrograde axonal transport of phosphofructokinase activity. Rats with streptozotocin-induced diabetes of 4 weeks duration showed phosphofructokinase activity accumulation deficits both proximal (53% and 65% in two separate experiments) and distal (80% and 70%) to 24-h sciatic nerve constrictions. There was no significant effect of diabetes on the phosphofructokinase activity per unit length in unconstricted sciatic nerve. Treatment of a group of diabetic rats with the aldose reductase inhibitor, sorbinil, profoundly reduced the concentrations of polyol pathway metabolites (sorbitol and fructose) in sciatic nerve. This effective inhibition of aldose reductase did not alter the accumulation deficits of phosphofructokinase activity on either side of sciatic nerve constrictions. We conclude that short-term experimental diabetes causes impaired axonal transport of phosphofructokinase activity by mechanisms unrelated to aldose reductase.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Tomlinson DR,Willars GB,Calthrop-Owen EFdoi
10.1016/0014-4886(87)90180-4subject
Has Abstractpub_date
1987-04-01 00:00:00pages
194-202issue
1eissn
0014-4886issn
1090-2430journal_volume
96pub_type
杂志文章abstract::This study was performed to investigate the physicological properties of histaminergic neurons in intraocular hypothalamic transplants. Pieces of posterolateral hypothalamus containing the tuberomammillary nucleus were dissected from Embryonic Day 17 rat fetuses and transplanted into the anterior chamber of the eye of...
journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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journal_title:Experimental neurology
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pub_type: 杂志文章
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journal_title:Experimental neurology
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更新日期:1987-06-01 00:00:00
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pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1987-05-01 00:00:00
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1016/0014-4886(87)90080-x
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journal_title:Experimental neurology
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2004-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:1987-05-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
doi:10.1006/exnr.2000.7496
更新日期:2000-11-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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更新日期:2019-04-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章,评审
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更新日期:2015-08-01 00:00:00
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journal_title:Experimental neurology
pub_type: 杂志文章
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