Abstract：
:Grafting fetal striatal cells into the brain of Huntington's disease (HD) patients has raised certain expectations in the past decade as an effective cell-based-therapy for this devastating condition. We argue that the first requirement for successful transplantation is defining the window of plasticity for the striatum during development when the progenitor cells, isolated from their environment, are able to maintain regional-specific-identity and to respond appropriately to cues. The primary cell culture from human fetal striatal primordium described here consists of a mixed population of neural stem cells, neuronal-restricted progenitors and striatal neurons. These cells express trophic factors, such as BDNF and FGF2. We show that these neurotrophins maintain cell plasticity, inducing the expression of neuronal precursor markers and cell adhesion molecules, as well as promoting neurogenesis, migration and survival. We propose that BDNF and FGF2 play an important autocrine-paracrine role during early striatum development in vivo and that their release by fetal striatal grafts may be relevant in the setting of HD cell therapy.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Sarchielli E,Marini M,Ambrosini S,Peri A,Mazzanti B,Pinzani P,Barletta E,Ballerini L,Paternostro F,Paganini M,Porfirio B,Morelli A,Gallina P,Vannelli GBdoi
10.1016/j.expneurol.2014.04.021subject
Has Abstractpub_date
2014-07-01 00:00:00pages
130-47eissn
0014-4886issn
1090-2430pii
S0014-4886(14)00123-Xjournal_volume
257pub_type
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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doi：10.1006/exnr.1996.0050
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doi：10.1016/j.expneurol.2008.07.002
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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