Extracellular unit responses in the pulvinar-lateral posterior complex of the cat through electrical stimulation of substantia nigra reticulata and lateralis.

abstract：:Spinal ischemia is a frequent cause of paralysis. Here we explore the biological basis of ischemic preconditioning (IPC), the phenomenon in which a brief period of ischemia can confer protection against subsequent longer and normally injurious ischemia, to identify mediators of endogenous neuroprotection. Using microa...

journal_title：Experimental neurology

authors： Carmel JB,Kakinohana O,Mestril R,Young W,Marsala M,Hart RP

更新日期：2004-01-01 00:00:00

abstract：:Rats were injected with capsaicin or solvent on the 2nd day of life. Nine weeks later both animal groups were further subdivided: one was untreated and the other group underwent surgery consisting in either (a) removal of one sternohyoid superior muscle or (b) a sham operation. The sternohyoid superior muscles were re...

journal_title：Experimental neurology

authors： Müntener M

更新日期：1985-04-01 00:00:00

abstract：:While acute spinal cord injury has been the object of intensive research, chronic spinal cord injury has received less attention although most clinical cases of spinal cord injury become chronic. We attempted to surgically "repair" chronic and acute spinal cord injury in a complete transection rat model using a multip...

journal_title：Experimental neurology

authors： Fraidakis MJ,Spenger C,Olson L

更新日期：2004-07-01 00:00:00

abstract：:Regeneration of axons in the peripheral nervous system is enhanced by the removal of glycosaminoglycan side chains (GAGs) of chondroitin sulfate proteoglycans. However, some axons regenerate poorly despite such treatment, suggesting the existence of additional inhibitors. We compared the effects of enzymatic removal o...

journal_title：Experimental neurology

authors： Groves ML,McKeon R,Werner E,Nagarsheth M,Meador W,English AW

更新日期：2005-10-01 00:00:00

abstract：:The recently discovered endocannabinoid system (ECS), which includes endocannabinoids and the proteins that metabolize and bind them, has been implicated in multiple regulatory functions both in health and disease. Several studies have suggested that ECS is centrally and peripherally involved in the processing of pain...

journal_title：Experimental neurology

authors： Greco R,Gasperi V,Maccarrone M,Tassorelli C

更新日期：2010-07-01 00:00:00

abstract：:Human apolipoprotein E (apoE) is a 34.2kDa glycosylated protein with three isoforms (apoE2, apoE3 and apoE4). Experimental autoimmune neuritis (EAN), an animal model for human Guillain-Barré syndrome, is an immune-mediated experimental disorder of the peripheral nervous system (PNS). Increased susceptibility to EAN in...

journal_title：Experimental neurology

authors： Zhang HL,Mao XJ,Zhang XM,Li HF,Zheng XY,Adem A,Mix E,Zhu J

更新日期：2011-08-01 00:00:00

abstract：:Spasticity is a condition that can include increased muscle tone, clonus, spasms, and hyperreflexia. In this study, we report the effect of manually stimulating the dorsal lumbosacral skin on spontaneous locomotor-like activity and on a variety of reflex responses in 5 decerebrate chronic spinal cats treated with clon...

journal_title：Experimental neurology

authors： Frigon A,Thibaudier Y,Johnson MD,Heckman CJ,Hurteau MF

更新日期：2012-06-01 00:00:00

abstract：:Immune rejection of transplanted material is a potential complication of organ donation. In response to tissue transplantation, immune rejection has two components: a host defense directed against the grafted tissue and an immune response from the grafted tissue against the host (graft vs host disease). To treat immun...

journal_title：Experimental neurology

authors： Weiss ML,Mitchell KE,Hix JE,Medicetty S,El-Zarkouny SZ,Grieger D,Troyer DL

更新日期：2003-08-01 00:00:00

abstract：:Trophic factors are expressed by neurons throughout several areas of the CNS. We studied the mRNA expression of a member of the neurotrophin family, brain-derived neurotrophic factor (BDNF), and of the two receptor transcripts, full-length trkB and truncated trkB in single intraocular cortex cerebri grafts and in doub...

journal_title：Experimental neurology

authors： Humpel C,Giacobini MM,Wetmore C,Olson L

更新日期：1994-06-01 00:00:00

abstract：:To test the hypothesis that prepubertal exposure of LHRH neurons to a source of catecholamines and neuropeptides accelerates the onset of puberty, we examined the effects of autologous adrenal transplantation into the base of the third ventricle of the brain in juvenile female rhesus monkeys at 11-13 months of age. Th...

journal_title：Experimental neurology

authors： Gore AC,Saitoh Y,Terasawa E

更新日期：1996-08-01 00:00:00

abstract：:The aim of this study was to compare the physiological properties of single neurons in the glabrous (G) and heterogeneous (H) subdivisions of primary somatosensory digit 3 cortex of adult raccoons. Extracellular recordings were obtained from 50 G neurons whose receptive fields (RFs) were confined to the glabrous skin ...

journal_title：Experimental neurology

authors： Doetsch GS,Stoney SD Jr,Hauge DH

更新日期：1992-02-01 00:00:00

abstract：:Six patients with long-lasting spasticity resistant to different drug therapies including oral baclofen received a bolus injection of lumbar intrathecal baclofen. Electromyographic (EMG) reactions of leg muscles (soleus, tibialis anterior, quadriceps, and hamstrings) to standard stimuli and during attempts at voluntar...

journal_title：Experimental neurology

authors： Latash ML,Penn RD,Corcos DM,Gottlieb GL

更新日期：1989-02-01 00:00:00

abstract：:The development of transgenic mouse models of amyotrophic lateral sclerosis (ALS) allows the testing of neuroprotective agents. We evaluated the effects of five agents in transgenic mice with the G93A Cu,Zn superoxide dismutase mutation. A novel inhibitor of poly(ADP-ribose) polymerase showed no effects on survival. D...

journal_title：Experimental neurology

authors： Andreassen OA,Dedeoglu A,Friedlich A,Ferrante KL,Hughes D,Szabo C,Beal MF

更新日期：2001-04-01 00:00:00

abstract：:We have investigated the expression of TTX-sensitive (TTXs) and TTX-resistant (TTXr) sodium channel subtypes following injury to the inferior alveolar nerve (IAN), in order to determine their potential role in the development of trigeminal neuropathic pain. In seven anaesthetised ferrets, fluorogold (2%) was injected ...

journal_title：Experimental neurology

authors： Davies SL,Loescher AR,Clayton NM,Bountra C,Robinson PP,Boissonade FM

更新日期：2006-11-01 00:00:00

abstract：:Roles of protein kinases in mediating adaptive neuronal responses to activation of signal transduction pathways are well known. Recent findings suggest that kinases may also be involved in pathological processes in the nervous system. The present study employed cultured human cerebral cortical neurons to test the hypo...

journal_title：Experimental neurology

authors： Mattson MP

更新日期：1991-04-01 00:00:00

abstract：:Angiotensin II type 1 receptor (AT1R) blocker (ARB) has been reported to modify hypertensive cerebrovascular changes; however, it is not clear whether its protective effects are independent of blood pressure. The aim of this study was to clarify the role of AT1R-mediated signals in cerebral circulation by the chronic ...

journal_title：Experimental neurology

authors： Kumai Y,Ooboshi H,Ago T,Ishikawa E,Takada J,Kamouchi M,Kitazono T,Ibayashi S,Iida M

更新日期：2008-04-01 00:00:00

abstract：:Four lectins (Abrus precatorius (APA), Maackia amurensis (MAA), Momordica charantia (MCA) and Sambucus nigra (SNA)) have been used to identify glycohistochemically the microglial cells (MGC) activation in autoptic brain samples from Alzheimer's disease (AD) subjects. Three of these lectins (APA, MAA and MCA) have util...

journal_title：Experimental neurology

authors： Zambenedetti P,Giordano R,Zatta P

更新日期：1998-09-01 00:00:00

abstract：:Globoid cell leukodystrophy (GLD, Krabbe Disease) is a lysosomal storage disease, resulting from the genetic deficiency of galactosylceramidase (GALC). This disease is marked by accumulation of the cytotoxic lipid psychosine (Psy). Psychosine is known to induce oxidative stress in cultured cells, and this stress can b...

journal_title：Experimental neurology

authors： Hawkins-Salsbury JA,Qin EY,Reddy AS,Vogler CA,Sands MS

更新日期：2012-10-01 00:00:00

abstract：:The precise role of hypothalamic norepinephrine (NE) in the control of vasopressin (AVP) release has remained unclear, due to reports of both inhibitory and excitatory effects of NE and only a few studies with direct hypothalamic manipulations. The present study utilized a chronically implanted swivel brain cannula to...

journal_title：Experimental neurology

authors： Leibowitz SF,Eidelman D,Suh JS,Diaz S,Sladek CD

更新日期：1990-12-01 00:00:00

abstract：:The sub-thalamic nucleus (STN) is relevant to the preparation of movement ignition but its role in movement termination is uncertain. Fourteen patients with Parkinson's disease (PD) received local field potentials (LFPs) recording at the left STN on the fourth day after deep brain stimulation surgery. They performed p...

journal_title：Experimental neurology

authors： Hsu YT,Lai HY,Chang YC,Chiou SM,Lu MK,Lin YC,Liu YL,Chen CC,Huang HC,Chien TF,Lin SZ,Chen YY,Tsai CH

更新日期：2012-01-01 00:00:00

abstract：:Excitant amino acids are implicated in audiogenic seizure (AGS) susceptibility in the genetically epilepsy-prone rat (GEPR). In the present study systemic administration of NMDA receptor antagonists significantly decreased AGS severity in the GEPR. Systemic administration of the competitive NMDA antagonists 3-((+-)-2-...

journal_title：Experimental neurology

authors： Faingold CL,Randall ME,Naritoku DK,Boersma Anderson CA

更新日期：1993-02-01 00:00:00

abstract：:The development of the spinal cord represents one of the most complex structure developments of the central nervous system (CNS) as it has to unfold along the longitudinal axis and within segmental cues. There it has to cope with on the one hand connection to the periphery (skeletal muscle, dermomyotome, smooth muscle...

journal_title：Experimental neurology

authors： Wiese S,Faissner A

更新日期：2015-12-01 00:00:00

abstract：:The olfactory bulb is the target of neural progenitor cells that are generated in the subventricular zone of the lateral ventricle in the adult brain. This permanent neurogenesis is likely influenced by olfactory input to the bulb since previous studies have shown that cell proliferation and/or apoptotic death are sti...

journal_title：Experimental neurology

authors： Veyrac A,Didier A,Colpaert F,Jourdan F,Marien M

更新日期：2005-08-01 00:00:00

abstract：:Neuron loss in layer III of the entorhinal cortex (EC) occurs in patients with temporal lobe epilepsy and in several animal models of the disease and may play a role in the development of spontaneously recurring seizures. This damage can be reproduced in rats by a focal microinjection of the indirect excitotoxin amino...

journal_title：Experimental neurology

authors： Wu HQ,Schwarcz R

更新日期：1998-10-01 00:00:00

abstract：:In order to test the functional implication of herpes simplex virus (HSV) vector-mediated gene transfer after axonal injury, we injected replication-incompetent HSV vectors coding for the anti-apoptotic peptide Bcl-2 and the glial cell-derived neurotrophic factor (GDNF), separately or in combination into ventral spina...

journal_title：Experimental neurology

authors： Natsume A,Wolfe D,Hu J,Huang S,Puskovic V,Glorioso JC,Fink DJ,Mata M

更新日期：2003-12-01 00:00:00

abstract：:Previous studies have shown that traumatic brain injury (TBI) produces progressive degradation of cytoskeletal proteins including neurofilaments (e.g., neurofilament 68 [NF68] and neurofilament 200 [NF200]) within the first 24 h after injury. Thus, we employed immunofluorescence (light and confocal microscopy) to stud...

journal_title：Experimental neurology

authors： Posmantur RM,Newcomb JK,Kampfl A,Hayes RL

更新日期：2000-01-01 00:00:00

abstract：:Huntingtin is a cytoplasmic protein that is found in neurons and somatic cells. In patients with Huntington's disease (HD), the NH2-terminal region of huntingtin has an expanded polyglutamine tract. An abnormal protein interaction by mutant huntingtin has been proposed as a mechanism for HD pathogenesis. Huntingtin as...

journal_title：Experimental neurology

authors： Velier J,Kim M,Schwarz C,Kim TW,Sapp E,Chase K,Aronin N,DiFiglia M

更新日期：1998-07-01 00:00:00

abstract：:Peripheral nerve injury can result in formation of a neuroma, which is often associated with heightened sensitivity to normally innocuous stimuli as well as spontaneous dysesthesia and pain. The onset and persistence of neuropathic pain have been linked to spontaneous ectopic electrogenesis in axons within neuromas, s...

journal_title：Experimental neurology

authors： Persson AK,Gasser A,Black JA,Waxman SG

更新日期：2011-08-01 00:00:00

abstract：:Some forms of electrographic seizures are generated at the level of the cortical network. Neocortical kindling exhibits a resistance to produce generalized convulsive seizures, and therefore, it was rather difficult to use it to study the cortical epileptogenesis. Here, using supra-threshold cortical kindling, we repo...

journal_title：Experimental neurology

authors： Nita DA,Cissé Y,Timofeev I

更新日期：2008-06-01 00:00:00

abstract：:The purpose of this study was to assess the respiratory and tonic activity of the abdominal muscles and the postinspiratory activity of the diaphragm (stage 1 expiration) in rats during sleep while they breathed air, hypercapnic, and hypoxic gas mixtures. ECoG and neck EMG recordings enabled the differentiation to be ...

journal_title：Experimental neurology

authors： Sherrey JH,Pollard MJ,Megirian D

更新日期：1988-07-01 00:00:00