Announcement

abstract：:The accumulation of damage to DNA plays a significant role in the etiology of the aging process. The importance of nutrition in delaying the aging process is well recognized. L-carnitine is a quaternary ammonium compound heterogeneously distributed in the brain. In the present study the effect of L-carnitine on DNA da...

journal_title：Experimental neurology

authors： Juliet PA,Joyee AG,Jayaraman G,Mohankumar MN,Panneerselvam C

更新日期：2005-01-01 00:00:00

abstract：:Apolipoprotein E (apoE) is known to bind to at least five receptors, including the low-density lipoprotein (LDL) receptor-related protein (LRP), very low density LDL receptor (VLDL-R), LDL-R, apoE receptor 2 (apoER2), and megalin/gp330. In this context, the main objective of the present study was to better understand ...

journal_title：Experimental neurology

authors： Veinbergs I,Van Uden E,Mallory M,Alford M,McGiffert C,DeTeresa R,Orlando R,Masliah E

更新日期：2001-07-01 00:00:00

abstract：:Alzheimer's disease is associated with an age-related accumulation of Abeta and inflammation. The inflammatory mediator, TNFalpha activates a signaling cascade involving NFkappaB translocation to the nucleus and a beneficial or detrimental transcriptional response, depending on the age of the neurons and the type of s...

journal_title：Experimental neurology

authors： Patel JR,Brewer GJ

更新日期：2008-09-01 00:00:00

abstract：:Roles of protein kinases in mediating adaptive neuronal responses to activation of signal transduction pathways are well known. Recent findings suggest that kinases may also be involved in pathological processes in the nervous system. The present study employed cultured human cerebral cortical neurons to test the hypo...

journal_title：Experimental neurology

authors： Mattson MP

更新日期：1991-04-01 00:00:00

abstract：:Single-unit microelectrode studies were conducted to test the effects of systemic cocaine HCl on spontaneously firing single noradrenergic locus ceruleus (presynaptic) and cerebellar Purkinje (postsynaptic) neurons in rats in vivo. The spontaneous neuronal activity of all locus ceruleus neurons was inhibited by cocain...

journal_title：Experimental neurology

authors： Pitts DK,Marwah J

更新日期：1987-12-01 00:00:00

abstract：:Our previous study demonstrates that delayed (initiated 24h post injury) erythropoietin (EPO) therapy for traumatic brain injury (TBI) significantly improves spatial learning. In this study, we investigated the impact of inhibition of EPO treatment-mediated neurogenesis on spatial learning after experimental TBI. Youn...

journal_title：Experimental neurology

authors： Zhang Y,Chopp M,Mahmood A,Meng Y,Qu C,Xiong Y

更新日期：2012-05-01 00:00:00

abstract：:The ability to differentiate neural stem cells (NSCs) into dopamine neurons is fundamental to their role in cell replacement therapies for neurodegenerative disorders such as Parkinson's disease. We show here that when a clonal line (C17.2) of undifferentiated NSCs is transplanted into the intact or 6-hydroxydopamine-...

journal_title：Experimental neurology

authors： Yang M,Stull ND,Berk MA,Snyder EY,Iacovitti L

更新日期：2002-09-01 00:00:00

abstract：:Infant rats were subjected to pentylenetetrazol-induced convulsions on alternate days from 5 to 13 days of age. At 17 days of age, their susceptibility to the convulsant effects of hyperthermia was examined. It was found that previous pentylenetetrazol-induced convulsions caused a significant facilitation in the devel...

journal_title：Experimental neurology

authors： McCaughran JA Jr,Manetto C

更新日期：1983-01-01 00:00:00

abstract：:We examined the pharmacological basis for the suppression of the masseteric (jaw-closer) reflex which occurs during the behavioral state of active sleep. Accordingly, the masseteric reflex was recorded in intact, unanesthetized, normally respiring cats during naturally occurring states of wakefulness and active sleep....

journal_title：Experimental neurology

authors： Soja PJ,Finch DM,Chase MH

更新日期：1987-04-01 00:00:00

abstract：:Estimates were made of the changing volumes of discharge arising from the total populations of Ia and II spindle afferent fibers in the cat's deefferented medial gastrocnemius as the muscle was extended stepwise over its excursion range. The estimates were based on values reported elsewhere for (i) the incidence of ac...

journal_title：Experimental neurology

authors： Botterman BR,Eldred E

更新日期：1983-04-01 00:00:00

abstract：:The tendency of a rat to approach the wall of an open-field and to travel along the perimeter of the field (termed as "peritaxis" or "wall-facing") is affected by unilateral removal of the vibrissae. Peritaxis is lateralized by hemivibrissotomy. The finding that the dopamine agonist apomorphine reversed the direction ...

journal_title：Experimental neurology

authors： Steiner H,Bonatz AE,Huston JP,Schwarting R

更新日期：1988-03-01 00:00:00

abstract：:Traumatic brain injury (TBI) causes persistent neurologic deficits. Current therapies, predominantly focused upon cortical and hippocampal cellular survival, have limited benefit on cognitive outcomes. Striatal damage is associated with deficits in executive function, learning, and memory. Dopamine and cAMP regulated ...

journal_title：Experimental neurology

authors： Bales JW,Yan HQ,Ma X,Li Y,Samarasinghe R,Dixon CE

更新日期：2011-06-01 00:00:00

abstract：:Decreases in energy metabolism following traumatic brain injury (TBI) are attributed to impairment of glycolytic flux and oxidative phosphorylation. Glucose utilization post-TBI is decreased while administration of alternative substrates has been shown to be neuroprotective. Changes in energy metabolism following TBI ...

journal_title：Experimental neurology

authors： Greco T,Vespa PM,Prins ML

更新日期：2020-07-01 00:00:00

abstract：:The psychopathological impact of emotional stress on a specific individual varies markedly: while most escape the development of post-traumatic stress disorder and/or major depression, a select group of individuals demonstrate a vulnerability to succumb to these conditions. The past decade has witnessed an explosion i...

journal_title：Experimental neurology

authors： Krishnan V

更新日期：2014-11-01 00:00:00

abstract：:The axonal trajectories of inspiratory bulbospinal neurons were examined after deposition of the anterograde neuronal tracer phaseolus vulgaris leucoagglutinin (PHA-L) into the rostral ventral respiratory group in rats. At the level of the phrenic nucleus, PHA-L-labeled bulbospinal axons crossed the midline of the spi...

journal_title：Experimental neurology

authors： Goshgarian HG,Ellenberger HH,Feldman JL

更新日期：1991-01-01 00:00:00

abstract：:There is a consensus that active sleep (AS; i.e., REM sleep) is produced by cholinergic projections from the pedunculopontine tegmental nuclei (PPT) that activate AS-on neurons in the nucleus pontis oralis (NPO) that are components of the AS-Generator. However, there is a growing body of evidence indicating that other...

journal_title：Experimental neurology

authors： Xi M,Fung SJ,Zhang J,Sampogna S,Chase MH

更新日期：2012-11-01 00:00:00

abstract：:In the embryonic brain, the transcription factor Nkx2.1 is localized in the medial ganglionic eminence and the ventromedial part of the hypothalamus. In the present study, we examined the development of mesencephalic dopamine (DA) neuron system in mice lacking Nkx2.1. In normal mice, tyrosine hydroxylase-immunoreactiv...

journal_title：Experimental neurology

authors： Kawano H,Horie M,Honma S,Kawamura K,Takeuchi K,Kimura S

更新日期：2003-07-01 00:00:00

abstract：:Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding...

journal_title：Experimental neurology

authors： Pellegrini A,Zanotto L,Ermani M,Chemello R,Testa G

更新日期：1986-12-01 00:00:00

abstract：:Neuregulins have been shown to play an important role in the development of the central nervous system, but their function in adult tissues is still unclear. We investigated the expression of the neuregulin receptors erbB3 and erbB4 in the adult rat brain by in situ hybridization histochemistry. Areas with considerabl...

journal_title：Experimental neurology

authors： Steiner H,Blum M,Kitai ST,Fedi P

更新日期：1999-10-01 00:00:00

abstract：:Olfactory ensheathing cells (OEC) constitute a specialized population of glia that accompany primary olfactory axons and have been reported to facilitate axonal regeneration after spinal cord injury in vivo. In the present report we describe OEC neurotrophic factor expression and neurotrophic properties of OECs in vit...

journal_title：Experimental neurology

authors： Lipson AC,Widenfalk J,Lindqvist E,Ebendal T,Olson L

更新日期：2003-04-01 00:00:00

abstract：:Patients with inflammatory bowel disease (IBD) or irritable bowel syndrome (IBS) often experience increased sensory responsiveness in the urinary bladder reflecting neurogenic bladder overactivity. Here we demonstrate that colitis-induced up-regulation of the phospholipase C gamma (PLCγ) pathway downstream of brain-de...

journal_title：Experimental neurology

authors： Xia C,Shen S,Hashmi F,Qiao LY

更新日期：2016-11-01 00:00:00

abstract：:After spinal cord injury (SCI), the majority of individuals develop spasticity, a debilitating condition involving involuntary movements, co-contraction of antagonistic muscles, and hyperreflexia. By acting on GABAergic and Ca2+-dependent signaling, current anti-spastic medications lead to serious side effects, includ...

journal_title：Experimental neurology

authors： Bilchak JN,Yeakle K,Caron G,Malloy D,Côté MP

更新日期：2021-01-13 00:00:00

abstract：:Golgi and computer morphometric analysis of neuronal dendrites was done on four cases, one each of Tay-Sachs disease, infantile type 2 sialidosis, Hurler's syndrome, and Sanfilippo's syndrome. There were large meganeurites on pyramidal neurons in Tay-Sachs disease, and small ones in Hurler's and Sanfilippo's syndromes...

journal_title：Experimental neurology

authors： Takashima S,Becker LE,Chan FW,Augustin R

更新日期：1985-06-01 00:00:00

abstract：:Previous studies have demonstrated that neonatal cultures of astrocytes express functional endothelin (ET) receptors. To determine if similar ET receptors are expressed by adult glia we used 125I-ET-1 to examine the expression of ET receptors both in vivo in the normal and transected optic nerves of the rabbit and rat...

journal_title：Experimental neurology

authors： Rogers SD,Demaster E,Catton M,Ghilardi JR,Levin LA,Maggio JE,Mantyh PW

更新日期：1997-05-01 00:00:00

abstract：:Alzheimer's disease (AD) is a major neurodegenerative disorder in which overproduction and accumulation of amyloid beta (Abeta) peptides result in synaptic dysfunction. Recent reports strongly suggest that in the initial stages of AD glutamate receptors are dysregulated by Abeta accumulation resulting in disruption of...

journal_title：Experimental neurology

authors： Parameshwaran K,Dhanasekaran M,Suppiramaniam V

更新日期：2008-03-01 00:00:00

abstract：:Fluoxetine is one of the most promising drugs for improving clinical outcome in patients with ischemic stroke. This in vivo study investigated the hypothesis that fluoxetine may affect HIF-1α-Netrin/VEGF cascade, angiogenesis and neuroprotection using a rat model of transient middle cerebral artery occlusion (tMCAO). ...

journal_title：Experimental neurology

authors： Hu Q,Liu L,Zhou L,Lu H,Wang J,Chen X,Wang Q

更新日期：2020-07-01 00:00:00

abstract：:Spinal cord injury results in cell loss, disruption of neural circuitry and chronic functional impairment. Several different cell types generate progeny in response to injury, which participate in scar formation and remyelination. Work over the last few years has identified neural stem cells and delineated the stem ce...

journal_title：Experimental neurology

authors： Sabelström H,Stenudd M,Frisén J

更新日期：2014-10-01 00:00:00

abstract：:The antiretroviral toxic neuropathy, a distal sensory polyneuropathy associated with antiretroviral treatment, is a frequently occurring neurological complication during treatment of patients with AIDS and often leads to discontinuation of antiretroviral therapy. The mechanisms by which antiretroviral drugs contribute...

journal_title：Experimental neurology

authors： Sanna MD,Peroni D,Quattrone A,Ghelardini C,Galeotti N

更新日期：2015-05-01 00:00:00

abstract：:Administration of endogenous corticosterone to intact animals induces calbindin-D28k protein in the hippocampal CA1-CA2 subfields. The fact that this effect on calbindin-D28k was shown to be specific for the hippocampus argues for a receptor-mediated effect on gene expression. In addition, chronic pretreatment with co...

journal_title：Experimental neurology

authors： Rami A,Rabié A,Winckler J

更新日期：1998-02-01 00:00:00

abstract：:Cyclic nucleotides are thought to act as second messengers of neurotransmission inside central neurons, and cyclic guanosine monophosphate (cGMP) has been postulated to act as a messenger for muscarinic, cholinergic transmission. Nonetheless, the action of cGMP has not yet been established in identified cortical neuro...

journal_title：Experimental neurology

authors： Woody C,Gruen E,Sakai H,Sakai M,Swartz B

更新日期：1986-03-01 00:00:00