Abstract：
:Acute volume expansion is associated with a specific pattern of Fos expression and the goal of the present study was to evaluate the contribution of cardiac receptors to this response. Adult male rats were instrumented with pericardial catheters introduced at the level of the thymus. Rats were also catheterized for measuring blood pressure, heart rate, central venous pressure, and intravenous infusion. Each rat received a 200-microl intrapericardial (i.p.c) injection of 2% procaine or 0.9% NaCl. Rats were then volume expanded with isotonic saline (10% body weight in 10 min) or given a control infusion (0.01 ml/min for 10 min). Ninety minutes after the start of the infusion, the rats were anesthetized and perfused transcardially. Their brains were sectioned and processed for Fos, dopamine-beta-hydroxylase, and oxytocin immunocytochemistry. Volume expansion plus i.p.c. saline produced a significant increase in Fos expression in the nucleus of the solitary tract, the ventrolateral medulla, the area postrema, the locus coeruleus, the paraventricular nucleus of the hypothalamus, the perinuclear zone of the supraoptic nucleus, and oxytocin neurons in the supraoptic nucleus. The i.p.c. procaine significantly blocked Fos expression produced by the volume expansion in the all of the regions examined except for the area postrema and the SON oxytocin neurons.
journal_name
Exp Neuroljournal_title
Experimental neurologyauthors
Cunningham JT,Bruno SB,Higgs KA,Sullivan MJdoi
10.1006/exnr.2002.7863keywords:
subject
Has Abstractpub_date
2002-04-01 00:00:00pages
181-92issue
2eissn
0014-4886issn
1090-2430pii
S0014488602978635journal_volume
174pub_type
杂志文章abstract：:The effects of N-methyl-d-aspartate (NMDA) and non-NMDA receptor antagonists were compared on audiogenic seizures in the rats neonatally exposed to propylthiouracil (PTU). The rats treated with 0.02% PTU through mother's milk during days 0-19 after delivery showed a high incidence of audiogenic seizures consisting of ...
journal_title：Experimental neurology
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doi：10.1006/exnr.1998.6871
更新日期：1998-09-01 00:00:00
abstract：:The blood-brain barrier (BBB) constitutes a neurovascular unit formed by microvascular endothelial cells, pericytes, and astrocytes. Brain pericytes are important regulators of BBB integrity, permeability, and blood flow. Pericyte loss has been implicated in injury; however, how the crosstalk among pericytes, endothel...
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.08.001
更新日期：2013-11-01 00:00:00
abstract：:Activation of the visual system with a moving black and white geometric pattern resulted in dense patches or columns of 2-deoxyglucose label in primate extrastriate visual cortex. The three-dimensional reconstruction of these metabolic columns showed that they were arranged in irregularly shaped slabs which extended i...
journal_title：Experimental neurology
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abstract：:Parkinson's disease (PD) is a prevalent neurodegenerative disorder characterized by a progressive and extensive loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) and their terminals in the striatum, which results in debilitating movement disorders. This devastating disease affects over 1 m...
journal_title：Experimental neurology
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doi：10.1016/j.expneurol.2013.03.016
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abstract：:Electrophysiological studies on preganglionic neurons (PGNs) in the dorsal motor nucleus (DMN) of the vagus nerve has been hampered by technical limitations. Conventional electrical stimulation of the vagus nerve with cathodal square-wave pulses activates both preganglionic and afferent fibers. Thus, some PGNs cannot ...
journal_title：Experimental neurology
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abstract：:Peripheral nerve regeneration following injury occurs spontaneously, but many of the processes require metabolic energy. The mechanism of energy supply to axons has not previously been determined. In the central nervous system, monocarboxylate transporter 1 (MCT1), expressed in oligodendroglia, is critical for supplyi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.10.018
更新日期：2015-01-01 00:00:00
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journal_title：Experimental neurology
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journal_title：Experimental neurology
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1998.6944
更新日期：1998-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/S0014-4886(03)00334-0
更新日期：2003-12-01 00:00:00
abstract：:Recent evidence indicates that protein aggregation and in particular the formation of toxic protein oligomers is a key mechanism in synucleinopathies such as Parkinson's disease (PD). Post mortem brain tissue studies as well as animal studies furthermore suggest that matrix metalloproteinases (MMPs) are also involved ...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2008.10.010
更新日期：2009-01-01 00:00:00
abstract：:In this study, we examined modulations in phosphatase and tensin homolog (PTEN) and mammalian target of rapamycin (mTOR) protein expression after a lateral C2 hemisection and subsequent intermittent hypoxia (IH) exposure and training, which initiates respiratory motor plasticity and recovery. PTEN and mTOR are signifi...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2013.05.013
更新日期：2013-10-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90268-7
更新日期：1985-07-01 00:00:00
abstract：:Transforming growth factor-alpha (TGF-alpha), previously identified as a major member of the epidermal growth factor (EGF) family of growth factors, plays a role in proliferation, differentiation, and survival of neuronal and glial precursors and is implicated in development of the nervous system. However, its roles i...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2001.7771
更新日期：2001-11-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.2002.7958
更新日期：2002-09-01 00:00:00
abstract：:The effects of neonatal 6-hydroxydopamine (6-OHDA) treatment on the projection of locus coeruleus (LC) neurons to the dorsal part of the lateral geniculate nucleus (dLGN) were examined using histofluorescence and electrophysiological methods. Histofluorescence studies confirmed the previous results of Gustafson and Mo...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(91)90128-y
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7163
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1993.1187
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(85)90120-7
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1006/exnr.1999.7332
更新日期：2000-03-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.04.004
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journal_title：Experimental neurology
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doi：10.1016/0014-4886(84)90084-0
更新日期：1984-12-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2006.01.037
更新日期：2006-05-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章,评审
doi：10.1016/j.expneurol.2013.05.001
更新日期：2013-08-01 00:00:00
abstract：:In human diabetes, degenerative and functional disorders of the central nervous system, including depression, are common findings. Defective dentate gyrus (DG) neurogenesis is associated with affective-related disorders and depression. We previously demonstrated reduced DG neurogenesis in a pharmacological type 1 diab...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2007.11.009
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2010.01.020
更新日期：2010-06-01 00:00:00
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journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/j.expneurol.2014.01.007
更新日期：2014-04-01 00:00:00
abstract：:Sarcoplasmic reticulum (SR) of high purity and functional integrity was isolated from skeletal muscle of normal and ethanol-tolerant rats. Ethanol at low concentrations (0.1 to 0.2 M), added in vitro to isolated SR, resulted in slight inhibition of both calcium loading and calcium-stimulated ATPase rates. Higher conce...
journal_title：Experimental neurology
pub_type： 杂志文章
doi：10.1016/0014-4886(83)90308-4
更新日期：1983-06-01 00:00:00
