Abstract：
:Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to basal cell carcinoma (BCC) or Bowen disease. We performed a retrospective analysis of the pathology records of a series of LK lesions with reference to the demographic features and accuracy of clinical diagnosis. The pathology records from 2008 to 2009 of 263 consecutive patients with a histological diagnosis of LK from a specialized skin laboratory were retrieved. Data relating to clinical diagnosis, age, sex, anatomical location, time of year of presentation and any coexistent pathological lesions adjacent to the LK were recorded. Mean age at presentation was 64 years (range 34-96), and 58% of patients were female. The most common anatomical site was the chest/anterior torso, followed by the back and legs. The most common coexisting lesion was solar keratosis at 14%, followed by seborrhoeic keratosis (SK) at 7.8%. The correct clinical diagnosis of LK was made in 29.5% of cases. The most common clinical diagnosis was BCC (47%), while SK was the preferred diagnosis in 18%. A clinical diagnosis was not given in 5.5% of cases. In conclusion, it appears that LK is frequently misdiagnosed, with misdiagnosis occurring in > 70% of cases in this study.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Maor D,Ondhia C,Yu LL,Chan JJdoi
10.1111/ced.13178subject
Has Abstractpub_date
2017-08-01 00:00:00pages
663-666issue
6eissn
0307-6938issn
1365-2230journal_volume
42pub_type
杂志文章abstract：:Vitiligo usually begins in childhood with approximately half of the patients manifesting onset of disease prior to the age of 20 years. Treatment options in this age group are few and have disappointing response rates. This study was designed to evaluate the role of narrow-band UVB in the treatment of generalized viti...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2005.01837.x
更新日期：2005-07-01 00:00:00
abstract：:Thalidomide has been used as an effective treatment for prurigo nodularis (PN) with a median dose of 200 mg, but the risk of peripheral neuropathy precludes long-term use. We analysed the efficacy of low-dose thalidomide (< 100 mg) in 17 patients with recalcitrant PN. Patients were initiated on thalidomide 50 mg on al...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.14015
更新日期：2020-01-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2007.02413.x
更新日期：2007-09-01 00:00:00
abstract：:Summary Mid-dermal elastolysis is an unusual process characterized by the absence of the elastic fibres within the mid-dermis. The disappearance of these fibres causes fine wrinkles (type 1) or perifollicular protrusions (type 2) affecting the trunk, neck and arms. There is a female predilection, and most patients hav...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03736.x
更新日期：2010-07-01 00:00:00
abstract：INTRODUCTION:Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM:To investigate the association between IL-17A a...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.12438
更新日期：2015-01-01 00:00:00
abstract：:It is well known that primary systemic amyloidosis [light chain (AL) amyloidosis] is associated with hidden dyscrasia or multiple myeloma. Acquired cutis laxa (cutis laxa acquisita; CLA) has also been described in patients with plasma cell dyscrasias, including multiple myeloma. We report a case in which haemorrhagic ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.13084
更新日期：2017-06-01 00:00:00
abstract：:Acne is a common and complex skin disease, with a very complex pathogenesis. Although in women the relationship between acne and insulin resistance is well known, in particular in women with PCOS, in males this relationship has been poorly investigated. In total, 20 subjects with an altered metabolic profile were cons...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ced.12673
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Port-wine stains (PWS) are congenital capillary malformations that persist throughout life. Laser therapy is a common treatment for PWS, and pulsed-dye laser is the current treatment of choice. AIM:To compare the clinical results on untreated PWS of two dye lasers with different wavelengths and pulse durati...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03399.x
更新日期：2010-03-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1993.tb00974.x
更新日期：1993-01-01 00:00:00
abstract：:It is a common experience that many Spitz naevi deviate from the idealized or stereotypical representation found in the literature, often causing considerable difficulties in distinguishing them from melanoma. The diagnostic term 'atypical Spitz naevus' is used to describe lesions that deviate from the typical appeara...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2007.02639.x
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe u...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.13641
更新日期：2018-12-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03234.x
更新日期：2009-12-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2230.2008.03096.x
更新日期：2009-08-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.2001.00849.x
更新日期：2001-07-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2230.2007.02539.x
更新日期：2008-03-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02093.x
更新日期：1990-07-01 00:00:00
abstract：:The primary cause of collagen degeneration in necrobiosis lipoidica (NL) is proposed to be immunologically mediated vascular disease. Ultraviolet (UV)A1 has been used successfully to treat scleroderma in which both vascular damage and collagen dysregulation also occur. We treated six patients with NL [(five women; mea...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2005.02059.x
更新日期：2006-03-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.2000.00579.x
更新日期：2000-01-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2005.01722.x
更新日期：2005-05-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03523.x
更新日期：2010-06-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.12617
更新日期：2015-08-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1993.tb02250.x
更新日期：1993-09-01 00:00:00
abstract：:The use of an aqueous solution of 0.5% topical glycopyrollate was effective in the treatment of hyperhidrosis of the scalp and forehead after other treatments had proved ineffective; this appears to be the first report of its use in this condition. ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.1998.00356.x
更新日期：1998-09-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：
更新日期：1996-03-01 00:00:00
abstract：:Histology sections from 61 cases of squamous cell carcinoma (SCC) of the vulva presenting after 1988 were reviewed for evidence of associated epithelial abnormality. Of the 50 patients with epithelium adjacent to the tumour, 24 had histological evidence of lichen sclerosus (LS), 20 of severe vulvar intraepithelial neo...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：
更新日期：1996-09-01 00:00:00
abstract：:A family with pachyonychia congenita in which affected individuals showed nail involvement only is described. Pachyonychia congenita is a rare hereditary disorder inherited in an autosomal dominant manner. Various classifications of pachyonychia congenita have been suggested but none indicates nail involvement as a so...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1994.tb01263.x
更新日期：1994-11-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2004.01677.x
更新日期：2005-01-01 00:00:00
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journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1989.tb00938.x
更新日期：1989-05-01 00:00:00
abstract：:Actinic prurigo (AP) has been found to be strongly associated with HLA DR4 and in particular with the DR4 subtype DRB1*0407. However, AP may occur in the absence of HLA-DR4. Furthermore, it has been shown that HLA-DR4 and DRB1*0407, even in association with polymorphic light eruption (PLE), are insufficient for the ex...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.2001.00922.x
更新日期：2001-11-01 00:00:00
abstract：:Down's syndrome (DS) is associated with rare dermatological disorders and increased frequency of some common dermatoses. Owing to advances in medical care and changes in attitude, the median age of death in this population has increased to 49 years, and the life expectancy of a 1-year-old person with DS today is more ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2230.2006.02164.x
更新日期：2006-09-01 00:00:00
