Abstract:
BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe under SEM the in vivo ultrastructural changes of tinea unguium caused by Trichophyton rubrum before and after itraconazole (ICZ) therapy, and to explore the in vivo antifungal effect of ICZ. METHODS:Ten outpatients diagnosed by mycology and SEM as having with tinea unguium caused by T. rubrum were recruited. They received ICZ pulse therapy (200 mg twice/day for 1 week, stop for 3 weeks, repeated for 3-4 months). Clinical change, mycology and SEM results were obtained after therapy. RESULTS:After ICZ therapy, 3 of the 10 cases were positive by both mycology and SEM; the latter showed completely dry, shrivelled, curved and folded hyphae with a relatively smooth surface or local destruction. Several hyphae remained intact with only some local bumps or crimps. The other cases were negative by SEM, but two were positive by mycology. CONCLUSION:In vivo ultrastructural changes of hyphae of T. rubrum in tinea unguium after ICZ treatment could be seen under SEM, demonstrating that ICZ fungistasis was effective and that SEM is a good tool for evaluating the effectiveness of ICZ in vivo. To our knowledge, this study is the first to show by SEM ICZ permeates the affected nail plate via the nail bed capillaries.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Yue X,Wang A,Sun Y,Li Qdoi
10.1111/ced.13641subject
Has Abstractpub_date
2018-12-01 00:00:00pages
883-889issue
8eissn
0307-6938issn
1365-2230journal_volume
43pub_type
杂志文章abstract::We report a rare case of cutaneous abscess by Trichosporon asahii in an immunocompetent adult. A 31-year-old Korean woman presented to our hospital with a cutaneous abscess. She had received an intralesional steroid injection 4 months earlier on the site of a hypertrophic scar. Direct sequencing of the intergenic spac...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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abstract:BACKGROUND:Cutis marmorata telangiectatica congenita (CMTC) is a congenital vascular anomaly of unknown aetiology. About 300 cases have been reported in the literature. The rate of associated anomalies varies between 20% and 70%. METHODS:We report a series of 27 children with CMTC, 18 of whom were followed-up prospect...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2008.03074.x
更新日期:2009-04-01 00:00:00