Abstract:
BACKGROUND:Alopecia areata (AA) is an organ-specific autoimmune disease characterized by folliculotropic T-cell infiltrates around anagen-stage hair follicles. The role of T helper (Th)1 and Th2 cytokines in the pathogenesis of AA have not been established. AIM:To determine whether serum cytokine profiles define the severity of the AA phenotype or are affected by co-existent atopy. METHODS:In total, 17 serum cytokines were measured and compared in 269 patients with AA of varying severity with and without atopy and 18 unrelated controls. RESULTS:Of the 269 patients with AA, 96% had active disease and 54% were atopic. The disease phenotype was transient patchy AA in 27 patients, persistent patchy AA in 89 and alopecia totalis or alopecia universalis in 153. Levels of Th1, interleukin (IL)-1 receptor antagonist (ra) and IL-8 levels were higher in all patients with AA than in controls. IL-1alpha, IL-12 and tumour necrosis factor-alpha levels were higher in patients with AA and atopy than in patients with AA without atopy. CONCLUSIONS:Increased Th1 serum cytokines (IL-2, IL-12 and interferon-gamma) and IL-1ra levels are associated with AA regardless of disease severity or the presence of atopy.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Barahmani N,Lopez A,Babu D,Hernandez M,Donley SE,Duvic Mdoi
10.1111/j.1365-2230.2009.03523.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
409-16issue
4eissn
0307-6938issn
1365-2230pii
CED3523journal_volume
35pub_type
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