Abstract：
:Twenty-six men who presented with male pattern baldness (androgen-dependent alopecia), were quantitatively evaluated for scalp hair variables and compared with 13 age-matched controls. Compared to controls, significant mean differences for hair variables were found in the frontal-vertex area, while in the occipital area, a reduction in total hair density (hairs/cm2) was the only significant (P less than 0.05) finding. A large proportion (48.5%) of meaningful hair (non-vellus hair) was less than or equal to 40 mm in length, yet had diameters similar to hairs growing much longer. In controls, these hairs accounted for only 12.2% of the total population. Compared to baseline, mean values from the frontal-vertex area of subjects with androgen-dependent alopecia were significantly lower for total hair density, meaningful hair density (non-vellus hairs/cm2) and percentage of hair in the anagen growth phase, 12 and 24 months later. During this time, total hair density decreased by 6.5% after 12 months and by 11.9% after 24 months. Similarly, meaningful hair density declined at 12 months by 10.8% and by 22.7% after 24 months. No change in any hair variable was detected in controls after 12 or 24 months. Our findings suggest that medications capable of maintaining the existing hair population should be regarded as effective treatments for this condition. Left untreated androgen-dependent alopecia progressively deteriorates. The induction of non-vellus hairs less than or equal to 40 mm in length to grow longer, would substantially improve the aesthetic profile without the need to generate new hair.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Rushton DH,Ramsay ID,Norris MJ,Gilkes JJdoi
10.1111/j.1365-2230.1991.tb00343.xsubject
Has Abstractpub_date
1991-05-01 00:00:00pages
188-92issue
3eissn
0307-6938issn
1365-2230journal_volume
16pub_type
杂志文章abstract：:Azathioprine is used in a variety of dermatological conditions. However, because of its side-effect profile, azathioprine is limited for use in patients with severe disease. An unpredictable, rare and potentially fatal side-effect of azathioprine is the development of a hypersensitivity reaction, often consisting of f...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2230.1995.tb01343.x
更新日期：1995-07-01 00:00:00
abstract：:This review provides a summary of key findings from 24 systematic reviews of atopic eczema (AE) published or indexed between 1 August 2010 and 31 December 2011, updating published summaries from previous years. Epidemiological evidence points to the protective effects of early daycare, endotoxin exposure, consumption ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/ced.12143
更新日期：2013-07-01 00:00:00
abstract：:Chronic photodamage of the skin manifests itself as extrinsic skin ageing (photoageing) and photocarcinogenesis. DNA photodamage and UV-generated reactive oxygen species are the initial molecular events that lead to most of the typical histological and clinical manifestations of chronic photodamage of the skin. Knowle...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2230.2001.00893.x
更新日期：2001-10-01 00:00:00
abstract：BACKGROUND:Regulatory T cells (Tregs), together with tolerogenic dendritic cells (tDCs) are involved in maintaining peripheral tolerance. A recent report suggested both Tregs and tDCs may be pathogenic in granulomatous skin disorders. AIM:To examined the expression of CD39 on granuloma-composing cells and Foxp3-positi...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.12094
更新日期：2013-12-01 00:00:00
abstract：:This article forms part of a series of annual updates that summarizes the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2017, and focuses on the epidemiology, aetiology and risk factors of AE. AE is the largest single contri...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/ced.14075
更新日期：2019-12-01 00:00:00
abstract：:Small tufts of chest hair were epilated at different rates and the roots classified as to growth phase, presence or absence of root sheaths and whether the shafts were fractured. With respect to anagen roots, a slow epilation gives bare roots whereas an increase in the rate of epilation increases the proportion of ens...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1992.tb00173.x
更新日期：1992-03-01 00:00:00
abstract：BACKGROUND:Data on the dermoscopic features of fungal melanonychia are limited. AIM:To identify the dermoscopic features of fungal melanonychia. METHODS:We reviewed patient files, clinical history and dermoscopic images of all cases with a diagnosis of fungal melanonychia seen at our dermoscopy unit within the past y...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.12552
更新日期：2015-04-01 00:00:00
abstract：:Actinic prurigo (AP) has been found to be strongly associated with HLA DR4 and in particular with the DR4 subtype DRB1*0407. However, AP may occur in the absence of HLA-DR4. Furthermore, it has been shown that HLA-DR4 and DRB1*0407, even in association with polymorphic light eruption (PLE), are insufficient for the ex...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.2001.00922.x
更新日期：2001-11-01 00:00:00
abstract：:We report a case of a 56-year-old woman who presented with a severe exacerbation of psoriasis with concurrent hypoglycaemic episodes. Methotrexate 17.5 mg weekly was required to control her psoriasis. Investigation of her hypoglycaemia showed raised levels of insulin, C-peptide and proinsulin. Radiological investigati...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2007.02578.x
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Androgenic alopecia is known to be androgen-dependent. Insulin is found in hair follicles and may play a role in the regulation of androgen metabolism and the hair-growth cycle. OBJECTIVES:To compare the insulin resistance between people with androgenic alopecia and a control group. METHODS:A case-control ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1365-2230.2008.03118.x
更新日期：2009-08-01 00:00:00
abstract：:We report a man with a 3-year-history of a striking eruption of small, 2-3 mm diameter keratotic, crateriform papules distributed symmetrically over the lower limbs. Morphologically the individual papules closely resembled those described in acrokeratoelastoidosis (AK) of Costa and in focal acral hyperkeratosis of Dow...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1046/j.1365-2230.2001.00810.x
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Cutis marmorata telangiectatica congenita (CMTC) is a congenital vascular anomaly of unknown aetiology. About 300 cases have been reported in the literature. The rate of associated anomalies varies between 20% and 70%. METHODS:We report a series of 27 children with CMTC, 18 of whom were followed-up prospect...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2230.2008.03074.x
更新日期：2009-04-01 00:00:00
abstract：:Chronic spontaneous urticaria (CSU) is a common and disabling skin disease which is often associated with psychiatric comorbidities such as anxiety and depression. These conditions are widely thought to cause, drive and/or maintain CSU, and have been reported as making an important contribution to the low quality of l...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/ced.12190
更新日期：2013-12-01 00:00:00
abstract：:A 65-year-old female suffered trauma to her left hand on which acrodermatitis continua (psoriasis of Hallopeau) developed. It is suggested that the persistent pain of this skin condition, its poor response to treatment and her allied mental state led to the development of a severe algodystrophy with marked underlying ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1989.tb02609.x
更新日期：1989-11-01 00:00:00
abstract：:Photodynamic therapy (PDT) with topical 5-aminolaevulinic acid (5-ALA) is a promising new treatment for superficial malignant nonmelanoma tumours, including cutaneous malignant lymphoma. Here, we report a case of cutaneous anaplastic large cell lymphoma effectively treated by PDT with topical 5-ALA in combination with...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2004.01448.x
更新日期：2004-01-01 00:00:00
abstract：:Precalcaneal congenital fibrolipomatous hamartoma (PCFH) is a condition that is seldom reported in the paediatric literature and rarely in the dermatological literature. It has other disparate and confusing names and as histology is rarely obtained, the condition may be under-reported. We describe this disorder in the...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2008.02984.x
更新日期：2009-06-01 00:00:00
abstract：:We describe the case of a 68-year-old woman who presented with asymptomatic skin nodules and symptoms of anaemia, and was found to have acute megakaryoblastic leukaemia with fibrosis, a condition now believed to correspond to the former diagnosis of acute myelofibrosis. There is only one previous report of skin lesion...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1996.tb00062.x
更新日期：1996-05-01 00:00:00
abstract：:Previous studies on the association of smoking with acne vulgaris have reported conflicting results. The objective of this study was to investigate such an association. Our setting was three primary care practices in Hong Kong and one primary care practice in India. Patient characteristics in all four practices are si...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2230.2004.01646.x
更新日期：2004-11-01 00:00:00
abstract：:The Laugier-Hunziker syndrome is an acquired, benign, macular hyperpigmentation of the lips and buccal mucosa. The nails are often involved with the development of melanonychia. Twenty-two previous cases have been recorded in the literature. We present details of six Caucasian patients with the Laugier-Hunziker syndro...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02044.x
更新日期：1990-03-01 00:00:00
abstract：:A 72-year-old woman with chronic renal failure requiring haemodialysis developed acute iododerma twice, after receiving iodide contrast dye for radiological procedures. Iododerma was localized to the face, scalp and elbows and was associated with papular purpura of the legs. Histopathology of the skin lesions showed a...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02079.x
更新日期：1990-05-01 00:00:00
abstract：:We present a patient with multiple leiomyomas confined to the left cheek, giving rise to an unusual clinical presentation of this condition. The lesions were cosmetically disfiguring and, because of their exposed location, were particularly painful in the winter months. The treatment of this condition is discussed. ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02094.x
更新日期：1990-07-01 00:00:00
abstract：:Identification of mutations in the hairless (HR) gene in patients with atrichia with papular lesions (APL) has proven of critical importance, as it provides a basis for the differentiation between APL and alopecia universalis. The establishment of the diagnostic criteria for APL has triggered the identification of a l...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2005.01762.x
更新日期：2005-07-01 00:00:00
abstract：:Postinflammatory hypopigmentation is a common cause of acquired hypopigmentary disorders. It can be a result of cutaneous inflammation, injury or dermatological treatment. There are also many specific conditions that present with hypopigmentation other than postinflammatory hypopigmentation. Most cases of postinflamma...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2230.2011.04088.x
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:In patients with psoriasis, videocapillaroscopy has been used to visualize the typical modifications in the microcirculatory architecture. AIM:To evaluate the modifications of the superficial capillary bed in a psoriatic plaque and healthy perilesional skin during treatment with a topical steroid. METHODS:...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03298.x
更新日期：2009-12-01 00:00:00
abstract：:Dapsone has potent anti-inflammatory effects, and is used in the treatment of leprosy, cutaneous vasculitis, neutrophilic dermatoses, and dermatitis herpetiformis and other blistering disorders. However, it may cause severe adverse reactions such as hypersensitivity syndrome, which is characterized by fever, skin rash...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2009.03527.x
更新日期：2009-12-01 00:00:00
abstract：:The case of an 80-year-old woman who developed extensive cutaneous calcification following intravenous phosphate administration is presented. Also the circumstances under which cutaneous calcification may occur are discussed. ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1993.tb02221.x
更新日期：1993-07-01 00:00:00
abstract：:We describe two patients with acral keratosis with a striking mosaic or jigsaw-puzzle pattern of keratotic papules on the dorsal aspects of the feet and adjacent parts of the legs. Both patients also showed mild diffuse palmoplantar keratosis and clavus-like lesions over the interphalangeal joints of the toes; one pat...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02114.x
更新日期：1990-09-01 00:00:00
abstract：:A 93-year-old woman with an 8-year history of episodes of fixed drug eruption due to paracetamol is described. The rash was characterized by bullae, crusted lesions, hyperpigmented and erythematous patches as well as lesions resembling toxic epidermal necrolysis. Direct immunofluorescence revealed deposition of IgG an...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1990.tb02093.x
更新日期：1990-07-01 00:00:00
abstract：:We report a rare case of cutaneous abscess by Trichosporon asahii in an immunocompetent adult. A 31-year-old Korean woman presented to our hospital with a cutaneous abscess. She had received an intralesional steroid injection 4 months earlier on the site of a hypertrophic scar. Direct sequencing of the intergenic spac...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.2006.02158.x
更新日期：2006-07-01 00:00:00
abstract：:A case of anti-Ro (SS-A) antibody-positive subacute cutaneous lupus erythematosus (LE) occurring in a 47-year-old male with Crohn's disease is described. This is a previously undescribed association. ...
journal_title：Clinical and experimental dermatology
pub_type： 杂志文章
doi：10.1111/j.1365-2230.1992.tb00182.x
更新日期：1992-03-01 00:00:00
