Abstract:
:Actinic prurigo (AP) has been found to be strongly associated with HLA DR4 and in particular with the DR4 subtype DRB1*0407. However, AP may occur in the absence of HLA-DR4. Furthermore, it has been shown that HLA-DR4 and DRB1*0407, even in association with polymorphic light eruption (PLE), are insufficient for the expression of the AP phenotype. It seems likely, therefore, that other genes in the HLA DR or adjacent regions may contribute to AP susceptibility. One possible predisposing factor in AP may be tumour necrosis factor (TNF)alpha as suggested by the good response of AP to the TNFalpha inhibitor thalidomide, and by the involvement of this cytokine in many immune responses. The aim of this study was to explore the relationship between AP and TNFalpha by examining the frequency of TNF2 in patients with AP, PLE and in normal controls. TNF1 and TNF2 are biallelic polymorphisms at position -308 of the TNFalpha gene promoter and are known to affect transcription of TNFalpha. TNF2 is the rarer of the two alleles and is associated with high functional levels of TNFalpha. This study confirms the positive linkage disequilibrium that has been described between HLA DR3 and TNF2, but fails to show an association between TNF2 and AP.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Grabczynska SA,Carey BS,McGregor JM,Hawk JL,Vaughan RWdoi
10.1046/j.1365-2230.2001.00922.xkeywords:
subject
Has Abstractpub_date
2001-11-01 00:00:00pages
700-4issue
8eissn
0307-6938issn
1365-2230pii
922journal_volume
26pub_type
杂志文章abstract::We present a case of paraneoplastic pemphigus associated with Castleman's disease. Our patient had stomatitis and vulvar erosions followed by a cutaneous polymorphous eruption. Investigations for neoplasia disclosed a Castleman's tumour suggesting the diagnosis of paraneoplastic pemphigus. The diagnosis was supported ...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1996.d01-177.x
更新日期:1996-01-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2230.2003.01209.x
更新日期:2003-03-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
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更新日期:2000-06-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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更新日期:1998-03-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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更新日期:1990-05-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
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更新日期:2004-09-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.0307-6938.2001.00947.x
更新日期:2002-01-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2002.01099.x
更新日期:2002-11-01 00:00:00
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journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2011.04179.x
更新日期:2012-01-01 00:00:00