A novel frameshift truncation mutation in the V2 tail domain of KRT1 causes mild ichthyosis hystrix of Curth-Macklin.

abstract：BACKGROUND:Lichen planus (LP) is an inflammatory disease of the skin and mucous membranes. Autoimmunity has been suggested as a possible cause of this disease. The cyclooxygenase enzymes (COX-1, COX-2) are the key enzymes in the conversion of arachidonic acid into prostaglandins. Prostaglandin E2 (PGE2), a key product ...

journal_title：Clinical and experimental dermatology

authors： El-Rifaie AA,Rashed LA,Doss RW

更新日期：2015-12-01 00:00:00

abstract：:There is variation in the treatment of lower limb cellulitis (LLC) with no agreement on the most effective antibiotic regimen. Many patients with cellulitis fail to respond to first-line antibiotics. This can negatively affect patient care and result in unnecessary hospital admissions. The aim of this systematic revie...

journal_title：Clinical and experimental dermatology

authors： Mistry K,Sharma S,Patel M,Grindlay D,Janjuha R,Smart P,Levell NJ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Regulatory T cells (Tregs), together with tolerogenic dendritic cells (tDCs) are involved in maintaining peripheral tolerance. A recent report suggested both Tregs and tDCs may be pathogenic in granulomatous skin disorders. AIM:To examined the expression of CD39 on granuloma-composing cells and Foxp3-positi...

journal_title：Clinical and experimental dermatology

authors： Fujimura T,Kambayashi Y,Aiba S

更新日期：2013-12-01 00:00:00

abstract：:Little is currently known about the relationship between melanocytic naevi and melanoma in terms of neoplastic progression. At histological examination, remnants of a pre-existing melanocytic naevus adjoining a melanoma are seen in 20-30% of cases. This study investigated dermoscopic features of 108 naevus-associated ...

journal_title：Clinical and experimental dermatology

authors： Stante M,Carli P,Massi D,de Giorgi V

更新日期：2003-09-01 00:00:00

abstract：:We report the occurrence of severe symptomatic bronchoconstriction in an atopic asthmatic subject following the application of coal tar bandages. Investigations showed that this was likely to have been caused by inhalation of coal tar vapour. We suggest that coal tar preparations should be used with caution in asthmat...

journal_title：Clinical and experimental dermatology

authors： Ibbotson SH,Stenton SC,Simpson NB

更新日期：1995-01-01 00:00:00

abstract：BACKGROUND:Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes. AIM:To determine whether genetic polymorphisms in the angiopoietin-1 (ANGPT1), angiopoietin-2 (ANGPT2) and caspase-5 (CASP5) genes are associated with an increased risk of developing pso...

journal_title：Clinical and experimental dermatology

authors： He L,Dang L,Zhou J,Bai J,Li YZ

更新日期：2015-07-01 00:00:00

abstract：:Japan is currently experiencing many outbreaks of scabies, occurring mainly in long-term care facilities. Scabies burrows, the only pathognomonic lesion for scabies, often occur on the creases of the palms, and are followed by a pattern of scale reminiscent of the 'wake' left on the surface of water by a moving bird o...

journal_title：Clinical and experimental dermatology

authors： Yoshizumi J,Harada T

更新日期：2009-08-01 00:00:00

abstract：:Recent studies suggest that histamine H2-receptor antagonists may be useful in the treatment of urticaria. This study was conducted to determine whether famotidine, a H2 antagonist, is effective in the treatment of acute urticaria and compare its effect with that of the H1 antagonist diphenhydramine. In this prospecti...

journal_title：Clinical and experimental dermatology

authors： Watson NT,Weiss EL,Harter PM

更新日期：2000-05-01 00:00:00

abstract：:Evidence has suggested that vascular endothelial growth factor (VEGF), a crucial growth factor in regulating endothelial progenitor cells (EPCs), plays a central role in keloid formation. However, the levels of circulating EPCs in patients with keloid have not yet been explored. The aim of this study was to determine ...

journal_title：Clinical and experimental dermatology

authors： Zhang GY,Wu LC,Liao T,Chen G,Chen YH,Meng XC,Wang AY,Chen SY,Lin K,Lin DM,Gao WY,Li QF

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:Effective treatment options for morphoea remain limited. As a result, there has been increasing interest in the role of phototherapy in the management of this condition. Aims. We report the findings of a study in which 13 patients with localized morphoea were treated with oral (n = 11) and topical (n = 2) ps...

journal_title：Clinical and experimental dermatology

authors： Usmani N,Murphy A,Veale D,Goulden V,Goodfield M

更新日期：2008-11-01 00:00:00

abstract：:Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

journal_title：Clinical and experimental dermatology

authors： Bosserhoff AK,Küster H,Hein R

更新日期：2004-11-01 00:00:00

abstract：INTRODUCTION:Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM:To investigate the association between IL-17A a...

journal_title：Clinical and experimental dermatology

authors： Narbutt J,Wojtczak M,Zalińska A,Salinski A,Przybylowska-Sygut K,Kuna P,Majak P,Sysa-Jedrzejowska A,Lesiak A

更新日期：2015-01-01 00:00:00

abstract：:We describe the challenging case of a patient presenting with extensive, eruptive mid-facial squamous cell carcinomas (SCCs) and keratoacanthomas (KAs) consequent to radiotherapy. Our patient had a personal and family history of multiple KAs and SCCs. Multiple self-healing squamous epithelioma, otherwise known as Ferg...

journal_title：Clinical and experimental dermatology

authors： Robertson SJ,Bashir SJ,Pichert G,Robson A,Whittaker S

更新日期：2010-06-01 00:00:00

abstract：:This randomized double-blind controlled study examined whether sulphydryl-containing agents influence the healing of venous ulceration occurring for the first time on the medial side of the leg. Graduated compression bandaging, which exerted a mean ankle pressure of 40.6 +/- 0.4 mmHg, and a mean below-knee pressure of...

journal_title：Clinical and experimental dermatology

authors： Salim AS

更新日期：1992-11-01 00:00:00

abstract：:Tumoral calcinosis is an uncommon ectopic calcification syndrome characterized clinically by the presence of irregular, painless, periarticular soft tissue calcifying masses, and pathologically by fibrous-walled cystic spaces containing structureless calcific debris and associated with a variable inflammatory reaction...

journal_title：Clinical and experimental dermatology

authors： Harwood CA,Cook MG,Mortimer PS

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:Multipotent cells can be isolated from dermis, and have wound-healing and antioxidant effects on human and murine skin. AIM:To investigate the changes in aged dermis after injection of dermal multipotent cells and adult fibroblasts. METHODS:Dermal multipotent cells were isolated and cultured from 3-day-old...

journal_title：Clinical and experimental dermatology

authors： Xue S,Li L

更新日期：2011-10-01 00:00:00

abstract：:Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease originating from the pilosebaceous unit, in which patients develop painful abscesses, sinus tracts, nodules and scarring, typically in intertriginous areas. Major gaps in our understanding of HS exist, and these may be partially due to the lack of an...

journal_title：Clinical and experimental dermatology

authors： Quartey QQ,Miller RJ,Pinsker BL,Okoh UJ,Shipman WD,George BA,Nwizu CC,Barnes LA,Kerns ML,Caffrey JA,Aliu O,Brown ID,Succaria F,Maynard JP,Herbert AS,Kang S,Miller LS,Okoye GA,Byrd AS

更新日期：2020-03-01 00:00:00

abstract：:Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

journal_title：Clinical and experimental dermatology

authors： Patel AN,Cohen SN,Leach IH,Scharrer K

更新日期：2012-04-01 00:00:00

abstract：:It is only in the past 10 years that the allergenic potential of topical corticosteroids has been fully realized. This has an important impact on the management of patients with chronic eczematous eruptions. Nonhalogenated topical steroids are more frequent sensitizers than halogenated molecules. Tixocortol pivalate a...

journal_title：Clinical and experimental dermatology

authors： English JS

更新日期：2000-06-01 00:00:00

abstract：:Despite scarring being a recognized sequel of acne, the actual extent and incidence of residual scarring remains unknown. One hundred and eighty-five acne patients were included in this study (101 females, 84 males). Patients were selected from acne clinics and their acne scarring was examined. The scarring was quanti...

journal_title：Clinical and experimental dermatology

authors： Layton AM,Henderson CA,Cunliffe WJ

更新日期：1994-07-01 00:00:00

abstract：:The clinical and histological effects of retinyl propionate cream (a retinyl ester) on extrinsic skin ageing (photo-ageing) in man were assessed in a double-blind randomized placebo-controlled study of 80 subjects, individual parameters of this being assessed for each treatment site (face, dorsal right forearm and han...

journal_title：Clinical and experimental dermatology

authors： Green C,Orchard G,Cerio R,Hawk JL

更新日期：1998-07-01 00:00:00

abstract：BACKGROUND:Recently, increased evidence has shown that serum micro (mi)RNA levels are a useful biomarker for the diagnosis, prognosis and therapeutic value of various diseases. However, serum miRNA has not been investigated in patients with systemic sclerosis (SSc), to our knowledge. AIM:To investigate the possibility...

journal_title：Clinical and experimental dermatology

authors： Makino K,Jinnin M,Kajihara I,Honda N,Sakai K,Masuguchi S,Fukushima S,Inoue Y,Ihn H

更新日期：2012-01-01 00:00:00

abstract：:A 68-year-old woman developed allergic contact dermatitis to topical metronidazole gel as proven by positive patch tests to the gel and to metronidazole. She was also allergic to methylchloroisothiazolinone and methylisothiazolinone (MC/MI). The similarity between the two molecules and the fact that the patient reacte...

journal_title：Clinical and experimental dermatology

authors： Wolf R,Orion E,Matz H

更新日期：2003-09-01 00:00:00

abstract：:COVID-19 is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). Vesicular skin rashes have been reported as associated with COVID-19, but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID-19 wh...

journal_title：Clinical and experimental dermatology

authors： Fernandez-Nieto D,Ortega-Quijano D,Jimenez-Cauhe J,Burgos-Blasco P,de Perosanz-Lobo D,Suarez-Valle A,Cortes-Cuevas JL,Carretero I,Garcia-Del Real C,Fernandez-Guarino M

更新日期：2020-10-01 00:00:00

abstract：:Verrucous cyst is an uncommon nonplantar epidermoid (infundibular) cyst with verrucous changes in its wall. We present the first case of trichilemmal cyst (isthmus-catagen cyst) with verrucous changes of its squamous lining. ...

journal_title：Clinical and experimental dermatology

authors： Misago N,Narisawa Y

更新日期：2005-01-01 00:00:00

abstract：:Multiple cutaneous and uterine leiomyomas is an autosomal dominant condition that results in benign smooth muscle tumours of the skin and, in females, uterine fibroids. This syndrome overlaps with hereditary leiomyomatosis and renal cell cancer syndrome in which affected individuals may develop the rare type II papill...

journal_title：Clinical and experimental dermatology

authors： Chan I,Wong T,Martinez-Mir A,Christiano AM,McGrath JA

更新日期：2005-01-01 00:00:00

abstract：:A case of pure non-epidermotropic cutaneous lymphoma in a human immunodeficiency virus-infected patient is reported following a viral opportunistic infection [cytomegalovirus (CMV) hepatitis]. The lymphoid infiltrate was Epstein-Barr virus and CMV negative with a CD30-positive T-cell phenotype. Molecular analysis demo...

journal_title：Clinical and experimental dermatology

authors： Viraben R,Brousset P,Aquilina C,Lamant L

更新日期：1997-11-01 00:00:00

abstract：:In 1990 we reported the trends in presentation of malignant melanoma (MM) from 1986 to 1988 in a defined population in South Wales. Ten years after this initial study we reassessed the incidence of invasive MM in this defined population over a similar 3 year period. Using the local skin cancer registry we identified 1...

journal_title：Clinical and experimental dermatology

authors： Holme SA,Malinovsky K,Roberts DL

更新日期：2001-09-01 00:00:00

abstract：:A 23-year-old woman presented with a 10 year history of excessive sweating (hyperhidrosis), mostly in the axillae, and to a lesser extent the groin and hands. Initial treatment with a sedative antihistamine and topical Driclor (aluminium chloride hexahydrate in 2% alcohol) for 14 weeks resulted in no improvement. Axil...

journal_title：Clinical and experimental dermatology

authors： Payne CM,Doe PT

更新日期：1998-01-01 00:00:00

abstract：:John Laws Milton, a 19th-Century surgeon, founded the St John's Hospital for Diseases of the Skin close to Leicester Square in London in 1863. This article reviews his single-minded effort to establish dermatology as a medical subspeciality and to create a proper skin diseases hospital. The review also details his man...

journal_title：Clinical and experimental dermatology

authors： Black MM

更新日期：2003-01-01 00:00:00