Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage.

Abstract:

BACKGROUND:We have previously reported that about 30% of patients affected by a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia (termed El Bagre-EPF or pemphigus Abreu-Manu) have systemic compromise. In the current study, we focused on studying autoreactivity to the kidney and its pathological correlations. AIM:To investigate patients with El Bagre-EPF for renal compromise. METHODS:We performed a case-control study, enrolling 57 patients with El Bagre-EPF and 57 controls from the endemic area, matched by age, sex, race, work activity, demographics and comorbidities. We took skin and renal biopsies; performed direct and indirect immunofluorescence, immunohistochemistry (IHC), confocal microscopy, immunoblotting, direct and indirect immune electron microscopy; and tested kidney function in all living patients. We also used IHC to study seven kidney autopsy samples. RESULTS:Of the 57 patients, 19 had autoantibodies to kidney, with polyclonal reactivity (P < 0.01). Most cases were positive along the basement membrane of the proximal tubules, but in some cases there was also positivity against the glomeruli and/or mixed patterns. Fifteen patients had increases in serum urea and creatinine compared with controls (P < 0.01). The autoantibodies colocalized with commercial antibodies to desmoplakins I and II, p0071, armadillo repeat gene deleted in velo-cardio-facial syndrome (ARCVF) and myocardium-enriched zonula occludens-1-associated protein (MYZAP) (P < 0.01). All of the kidney disease autopsies showed alterations, mostly in the vessels. CONCLUSION:We demonstrate for the first time that one-third of patients with El Bagre-EPF have polyclonal autoantibodies to kidney. The kidneys showed a mixed histological pattern resembling lupus nephritis, with a diffuse proliferative Class IV (G) global diffuse pattern in active lesions, and additional interposition of membranoproliferative glomerulonephritis.

journal_name

Clin Exp Dermatol

authors

Abreu-Velez AM,Howard MS,Yi H,Florez-Vargas AA

doi

10.1111/ced.13566

subject

Has Abstract

pub_date

2018-08-01 00:00:00

pages

692-702

issue

6

eissn

0307-6938

issn

1365-2230

journal_volume

43

pub_type

杂志文章
  • Topical tacrolimus has a limited direct effect on ultraviolet B-irradiated keratinocytes: implications for its photocarcinogenic potential.

    abstract:BACKGROUND:Topical tacrolimus has shown remarkable clinical efficacy in treating many dermatoses. Combining ultraviolet (UV) B and tacrolimus is an intriguing therapeutic regimen, especially for treatment of vitiligo, for which combination therapy may show greater clinical efficacy than topical tacrolimus alone. The ph...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03311.x

    authors: Lan CC,Yu HS,Huang SM,Wu CS,Kuo HY,Lee CH,Lin CS,Chen GS

    更新日期:2010-03-01 00:00:00

  • A new glycine substitution mutation in the COL7A1 gene in a Chinese family with dominant dystrophic epidermolysis bullosa.

    abstract::Dystrophic epidermolysis bullosa (DEB) is caused by mutations in the COL7A1 gene encoding type VII collagen, the major component of anchoring fibrils. The characteristic genetic lesion in dominant DEB (DDEB) is a glycine substitution in the collagenous domain of the protein. In this study, we identified a Chinese fami...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2003.01317.x

    authors: Zhang XJ,Song YX,Zhang XQ,Yang S,Li M,Li CR,Yang CJ,Yang J

    更新日期:2003-07-01 00:00:00

  • A tribute to Robert Willan in Bloomsbury Square.

    abstract::Robert Willan is commemorated by a blue plaque on the house in which he lived in Bloomsbury Square in London. He lived there during a productive period of his career, until ill-health caused him to travel to Madeira, where he died. This fitting tribute to Willan is the result of the efforts of Dr. Henry MacCormac, him...

    journal_title:Clinical and experimental dermatology

    pub_type: 传,历史文章,杂志文章

    doi:10.1111/j.1365-2230.2011.04022.x

    authors: Walker SL

    更新日期:2011-08-01 00:00:00

  • Everyday clinical experience of alitretinoin in the treatment of severe chronic hand eczema: seven case studies.

    abstract::Chronic hand eczema (CHE) is a debilitating and distressing disease for patients, the physical symptoms of which are compounded by psychosocial problems. Alitretinoin is an endogenously occurring physiological vitamin A derivative (retinoid) that possesses strong anti-inflammatory and immunomodulatory activity. It is ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2010.04006_1.x

    authors: English J,Graham-Brown R,de Sica Chapman A,Alexandroff AB

    更新日期:2011-03-01 00:00:00

  • Localized papular cutaneous schistosomiasis: two cases in travellers.

    abstract::Schistosomiasis is endemic in many parts of the tropics and subtropics with an estimated 200 million people, at least, infected worldwide. The symptoms and signs of vesical and gastrointestinal forms are readily recognized but ectopic forms are rare even in endemic areas and present a greater diagnostic challenge, par...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2001.00761.x

    authors: Leman JA,Small G,Wilks D,Tidman MJ

    更新日期:2001-01-01 00:00:00

  • Bullous skin reaction seen after extravasation of calcium gluconate.

    abstract::Intravenous (IV) calcium is usually given to temporarily treat the effects of hyperkalaemia on muscle and heart. When extravasation of a calcium gluconate infusion occurs, there may be rapid and marked swelling and erythema, with signs of soft-tissue necrosis or infection, and ensuing extensive local calcification, ca...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2012.04436.x

    authors: Celbek G,Gungor A,Albayrak H,Kir S,Guvenc SC,Aydin Y

    更新日期:2013-03-01 00:00:00

  • Age-related changes in wound healing.

    abstract::Knowledge of the physiology of wound healing, in particular the recovery of the dermal and epidermal compartments and the co-ordination of these processes by the cytokine network, is of great importance to rational wound management. The individual components of the wound healing process have been studied using various...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2230.1994.tb02684.x

    authors: Van de Kerkhof PC,Van Bergen B,Spruijt K,Kuiper JP

    更新日期:1994-09-01 00:00:00

  • Discoid lupus erythematosus of the eyelids associated with staphylococcal blepharitis and Meibomian gland dysfunction.

    abstract::Lower eyelid involvement occurs in 6% of patients with discoid lupus erythematosus (DLE). Eyelid lesions are rarely the initial manifestation of DLE. We describe a 25-year-old woman presenting with discoid lesions of the lower eyelids, staphylococcal blepharitis and Meibomian gland dysfunction, who later developed a d...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2005.01988.x

    authors: Ena P,Pinna A,Carta F

    更新日期:2006-01-01 00:00:00

  • Intravenous cidofovir for resistant cutaneous warts in a patient with psoriasis treated with monoclonal antibodies.

    abstract::Human papilloma virus is a common and often distressing cutaneous disease. It can be therapeutically challenging, especially in immunocompromised patients. We report a case of recalcitrant cutaneous warts that resolved with intravenous cidofovir treatment. The patient was immunocompromised secondary to monoclonal anti...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2011.04039.x

    authors: McAleer MA,Bourke J

    更新日期:2011-08-01 00:00:00

  • Leukonychia due to cytostatic agents.

    abstract::Chromonychia induced by antineoplastic agents has been known for several years. The most frequent of these is melanonychia, either diffuse or in tranverse or longitudinal bands, that may co-exist with diffuse pigmentation of the skin. Although any cytostatic agent may be involved in melanonychia, this condition appear...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1992.tb02166.x

    authors: Unamuno P,Fernández-López E,Santos C

    更新日期:1992-07-01 00:00:00

  • Efficacy of topical corticosteroids in nickel-induced contact allergy.

    abstract::In this study we used the nickel contact allergy patch (CAP) test to investigate the effect of topical corticosteroids on allergic contact dermatitis (ACD). On day 1, three CAP tests were applied for 48 h on the forearms of 20 female volunteers with a known nickel ACD. CAP of the right forearm contained 5% nickel, and...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.0307-6938.2001.00963.x

    authors: Hachem JP,De Paepe K,Vanpée E,Bogaerts M,Kaufman L,Rogiers V,Roseeuw D

    更新日期:2002-01-01 00:00:00

  • The Laugier-Hunziker syndrome--a clinical review of six cases.

    abstract::The Laugier-Hunziker syndrome is an acquired, benign, macular hyperpigmentation of the lips and buccal mucosa. The nails are often involved with the development of melanonychia. Twenty-two previous cases have been recorded in the literature. We present details of six Caucasian patients with the Laugier-Hunziker syndro...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1990.tb02044.x

    authors: Kemmett D,Ellis J,Spencer MJ,Hunter JA

    更新日期:1990-03-01 00:00:00

  • Cutaneous dissemination of nasal NK/T-cell lymphoma in a young girl.

    abstract::In Europe and the USA, the incidence of primary nasal natural killer (NK)/T-cell lymphoma is rare. The skin is one of the predilection sites for dissemination. Cutaneous dissemination is a poor prognostic sign and is consistently fatal. We describe the case of a 17-year-old white German girl with a primary nasal NK/T-...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2008.02777.x

    authors: Sandner A,Helmbold P,Winkler M,Gattenlöhner S,Müller-Hermelink HK,Holzhausen HJ

    更新日期:2008-08-01 00:00:00

  • Understanding the role of haptoglobin in psoriasis: effects of ultraviolet B.

    abstract:BACKGROUND:Haptoglobin (Hp) is one of the acute phase proteins, whose main function is to bind free haemoglobin (Hb) and transport it to the liver for degradation and iron recycling. In addition to its role as an Hb scavenger, Hp has been shown to behave as an anti-inflammatory, antioxidant and angiogenic factor. We pr...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12667

    authors: Maresca B,Lembo S,Ayala F,Balato N,Di Caprio R,Mattii M,Raimondo A,Schiattarella M,Abrescia P,Spagnuolo MS,Cigliano L,Balato A

    更新日期:2016-01-01 00:00:00

  • Giant nerve abscesses in leprosy.

    abstract::Two leprosy patients with neuritis caused by giant abscesses involving almost the entire ulnar nerve are described. One patient, who also had skin lesions, was diagnosed histopathologically as having borderline tuberculoid leprosy both on skin and nerve biopsy, and the other, with only nerve involvement, belonged to t...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1990.tb02110.x

    authors: Saxena U,Ramesh V,Misra RS,Mukherjee A

    更新日期:1990-09-01 00:00:00

  • Metallothionein I and II gene knock-out mice exhibit reduced tolerance to 24-h sodium lauryl sulphate patch testing.

    abstract:BACKGROUND:Metallothioneins (MTs) are a group of proteins widely distributed in tissues regulating metal metabolism, scavenging free radicals, and taking part in immunological reactions. Knockout mice for MT genes I and II (MT(-/-)) exhibit reduced tolerance to ultraviolet B injury in vivo. Upregulation of MT proteins ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2007.02399.x

    authors: Ma C,Li LF,Zhang BX

    更新日期:2007-07-01 00:00:00

  • Neutrophil folliculitis and serum androgen levels.

    abstract::Pruritic folliculitis (PF) is one of the specific dermatoses of pregnancy the aetiology of which remains unknown. Several theories have been proposed, and the most commonly accepted is that it represents a hormonally induced acne, as seen in patients taking progestogenic steroids. This theory led to the proposition th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.1999.00510.x

    authors: Vaughan Jones SA,Hern S,Black MM

    更新日期:1999-09-01 00:00:00

  • Allergic airborne contact dermatitis from essential oils used in aromatherapy.

    abstract::Contact allergy to various essential oils used in aromatherapy was demonstrated on patch testing in a 53-year-old patient suffering from relapsing eczema resistant to therapy on various uncovered parts of the skin, in particular the scalp, neck and hands. Sensitization was due to previous exposure to lavender, jasmine...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1995.tb02719.x

    authors: Schaller M,Korting HC

    更新日期:1995-03-01 00:00:00

  • The treatment of basal skin carcinomas in two sisters with xeroderma pigmentosum.

    abstract::Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder that causes defects in the DNA repair system. It is characterized by a marked sensitivity to sunlight, and sufferers develop serious sunburns with onset of poikilodermia in the light-exposed skin. Squamous cell carcinomas, basal cell carcinomas (BCCs) a...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.28.s1.10.x

    authors: Roseeuw D

    更新日期:2003-11-01 00:00:00

  • Leucoderma after use of a skin-lightening cream containing kojic dipalmitate, liquorice root extract and Mitracarpus scaber extract.

    abstract::A lighter or whiter complexion is socially desirable in many cultures. This has led to an unregulated and highly profitable market in skin-lightening creams that are readily available over the counter or on the internet. Plant extracts and newer tyrosinase inhibitors such as kojic acid or its derivative kojic dipalmit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03690.x

    authors: Madhogaria S,Ahmed I

    更新日期:2010-06-01 00:00:00

  • Erosive pustular dermatosis of the leg mimicking lower limb cellulitis.

    abstract::Erosive pustular dermatosis (EPD) of the leg is an unusual form of amicrobial pustulosis, which typically affects elderly patients with chronic venous insufficiency. We report a patient who presented with painful erythema, crusted erosions and pustules on her right lower leg. Histology showed a dermal infiltration mad...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12512

    authors: Zhou Z,Zhang ZK,Liu TH

    更新日期:2015-12-01 00:00:00

  • Extensive naevus comedonicus in a child with Alagille syndrome.

    abstract::Naevus comedonicus is a rare condition, thought to be a hamartoma in which cells of the pilosebaceous unit fail to develop appropriately. Although it is usually an isolated phenomenon, it has been associated with other defects, including those of the skeletal, ocular and central nervous system. A girl with this condit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1994.tb01149.x

    authors: Woods KA,Larcher VF,Harper JI

    更新日期:1994-03-01 00:00:00

  • Elevated MIA levels in the serum of pregnant women and of children.

    abstract::Recent studies have shown that the protein MIA (melanoma inhibitory activity) is a potent serum marker for malignant melanoma. MIA is expressed in chondrocytes at high levels, and might potentially be elevated during periods of growth in childhood. Therefore, we evaluated MIA serum levels in pregnant women and in grow...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2004.01623.x

    authors: Bosserhoff AK,Küster H,Hein R

    更新日期:2004-11-01 00:00:00

  • Liposuction for axillary hyperhidrosis.

    abstract::A 23-year-old woman presented with a 10 year history of excessive sweating (hyperhidrosis), mostly in the axillae, and to a lesser extent the groin and hands. Initial treatment with a sedative antihistamine and topical Driclor (aluminium chloride hexahydrate in 2% alcohol) for 14 weeks resulted in no improvement. Axil...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.1998.00248.x

    authors: Payne CM,Doe PT

    更新日期:1998-01-01 00:00:00

  • Doxycycline-induced hypoglycaemia.

    abstract::Tetracyclines, including doxycycline, are widely used drugs that form an integral part of daily prescribing, and serious adverse reactions (SARs) are rarely reported. The frequency of hypoglycaemia complicating tetracycline treatment remains unknown, and is not a recognized complication. We describe an 80-year-old man...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12692

    authors: Tan CH,Shelley C,Harman KE

    更新日期:2016-01-01 00:00:00

  • Predictors of patient satisfaction with initial diagnosis and management of malignant melanoma.

    abstract:BACKGROUND:Malignant melanoma (MM), accounts for around 10% of skin cancers. To date, there have been few data on patient satisfaction with initial management of MM. OBJECTIVE:To identify the predictors of patient satisfaction with initial diagnosis and management of MM. METHODS:Data on 214 patients were collected us...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03639.x

    authors: Sheth N,Sarker SJ,Harries M,Healy C,Russell-Jones R,Acland K

    更新日期:2010-08-01 00:00:00

  • Multiple dermatofibromata developing during pregnancy.

    abstract::Dermatofibromata are common benign dermal tumours of unknown aetiology. They usually present as a single lesion on the limbs of young adults. Multiple dermatofibromata have been reported occurring in patients with autoimmune disease, who were receiving immunosuppressive treatment. A 25-year-old female is reported who ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1994.tb01118.x

    authors: Stainforth J,Goodfield MJ

    更新日期:1994-01-01 00:00:00

  • Localized multiple neurofibromas.

    abstract::Two cases of localized multiple neurofibromas are reported. The patients had fairly large, closely grouped neurofibromas limited to a circumscribed part of the body, a very different clinical feature from segmental neurofibromatosis, but with otherwise had typical histopathological features. Possible aetiology is disc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1992.tb00205.x

    authors: Mohri S,Atsusaka K,Sasaki T

    更新日期:1992-05-01 00:00:00

  • Disseminated Kaposi's sarcoma associated with idiopathic CD4+ lymphocytopenia and low dose steroid therapy.

    abstract::A case of disseminated Kaposi sarcoma in a 76-year-old woman treated with low-dose steroids for a seronegative polyarthritis is described. HIV serology was negative, whereas PCR for HHV-8 was positive. The patient presented with a profound reduction in the peripheral blood CD4+ cell count and a decrease in serum immun...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2005.01795.x

    authors: Fierro MT,Savoia P,Quaglino P,Novero D,Bernengo MG

    更新日期:2005-07-01 00:00:00

  • Interferon-alpha therapy for melanoma.

    abstract::Although surgery may be curative in early malignant melanoma, its effect on survival lessens with each succeeding stage of the disease. A wide variety of immunological strategies have therefore been used to improve the prognosis of patients with malignant melanoma, but adjuvant therapy with interferon (IFN)-alpha is t...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2230.2000.00559.x

    authors: Russell-Jones R

    更新日期:2000-01-01 00:00:00