Low glycaemic diet and metformin therapy: a new approach in male subjects with acne resistant to common treatments.

Abstract:

:Acne is a common and complex skin disease, with a very complex pathogenesis. Although in women the relationship between acne and insulin resistance is well known, in particular in women with PCOS, in males this relationship has been poorly investigated. In total, 20 subjects with an altered metabolic profile were considered for this study and randomized as follows: 10 patients were treated with metformin plus a hypocaloric diet for 6 months (group A), while 10 patients did not receive any treatment with metformin and were only followed up (group B). All patients of group A, after 6 months of metformin therapy, had a statistically significant improvement compared with patients in group B. Our study reveals the importance of diet and insulin resistance in acne pathogenesis, and underlines the possible use of metformin and diet as possible adjuvant therapy for male patients with acne.

journal_name

Clin Exp Dermatol

authors

Fabbrocini G,Izzo R,Faggiano A,Del Prete M,Donnarumma M,Marasca C,Marciello F,Savastano R,Monfrecola G,Colao A

doi

10.1111/ced.12673

subject

Has Abstract

pub_date

2016-01-01 00:00:00

pages

38-42

issue

1

eissn

0307-6938

issn

1365-2230

journal_volume

41

pub_type

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