Abstract:
:A scleroderma-like disease has recently been described in association with taxanes. We present the first case of diffuse scleroderma occurring in a woman treated with doxorubicin and cyclophosphamide for breast cancer. The clinical pattern of skin involvement and histological alterations were identical to those found in the classical form of scleroderma. Skin involvement progressed to affect 80% of total body area, and subsequently remained unchanged despite progression of the underlying cancer, making a paraneoplastic aetiology of the scleroderma unlikely. Specific chemotherapeutic agents might be directly responsible for the clinical manifestations and the parameters of progression. Analysis of all similar case reports defines the particular features and clinical course of this phenomenon.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Alexandrescu DT,Bhagwati NS,Wiernik PHdoi
10.1111/j.1365-2230.2004.01668.xkeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
141-5issue
2eissn
0307-6938issn
1365-2230pii
CED1668journal_volume
30pub_type
杂志文章,评审abstract::Intravenous (IV) calcium is usually given to temporarily treat the effects of hyperkalaemia on muscle and heart. When extravasation of a calcium gluconate infusion occurs, there may be rapid and marked swelling and erythema, with signs of soft-tissue necrosis or infection, and ensuing extensive local calcification, ca...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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