Abstract:
BACKGROUND:Interferons are molecules with antiviral effects, which have been used for the treatment of verruca for many years. AIMS:To determine if sublesional interferon (IFN)-alpha injection offers an effective alternative treatment for common warts. METHODS:We compared the results of single-dose sublesional IFN application in different types of verruca and with placebo for the treatment of single verruca plantaris lesions. In total, 53 patients (mean age 22.6 years) were enrolled in the study. Of these, 45 patients received a single sublesional injection of 4.5 MU IFN-alpha2a (three study groups), and eight patients with single verruca plantaris lesions were injected with physiological saline as placebo (control group). As local anaesthesia, liquid nitrogen was sprayed only on to the injection site for 3-4 s. The injection was made directly under the lesion through the border of the lesion, at with approximately a 45 degrees angle from healthy skin. RESULTS:At the 12-month follow-up in the group of patients with single verruca plantaris, there were 19 complete cures (7.2%) and 2 partial responses (8.3%), and 3 patients (12.5%) had no response. In the control group, only 2 patients (25%) had a partial response to treatment. CONCLUSIONS:These results suggest that a single sublesional dose of 4.5 MU IFN-alpha may be of value in the treatment of patients with verruca, especially in those with single verruca plantaris lesions.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Aksakal AB,Ozden MG,Atahan C,Onder Mdoi
10.1111/j.1365-2230.2008.02924.xsubject
Has Abstractpub_date
2009-01-01 00:00:00pages
16-9issue
1eissn
0307-6938issn
1365-2230pii
CED2924journal_volume
34pub_type
杂志文章abstract::Sensitive skin (SS) is a widespread condition, but still not completely understood. To identify risk factors that increase the likelihood of SS, 258 women aged between 20 and 65 years old and resident in the Netherlands were surveyed by questionnaire, which included questions on sociodemographic characteristics (age g...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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doi:10.1111/j.1365-2230.1993.tb02239.x
更新日期:1993-09-01 00:00:00
abstract::The literature reveals what little is known about nutritional factors and hair loss. What we do know emanates from studies in protein-energy malnutrition, starvation, and eating disorders. In otherwise healthy individuals, nutritional factors appear to play a role in subjects with persistent increased hair shedding. H...
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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