Abstract:
BACKGROUND:Colonization of the skin of patients with atopic dermatitis (AD) by Staphylococcus aureus (SA) is associated with more severe disease. AIM:To determine the association of SA colonization patterns and densities in lesional and nonlesional skin in patients with varying severities of AD, and to determine the antibiotic sensitivity patterns of SA isolates from Sri Lanka. METHODS:Skin and nasal swabs collected from 100 patients with AD and 120 controls were used to investigate the presence of SA. Severity of AD was graded using the Nottingham Eczema Severity Score. Colony counts were obtained for skin samples, and antibiotic sensitivity testing was performed in cases positive for SA. RESULTS:Skin colonization was seen in 57 patients (57%) but in only 10 controls (8%). Lesional skin of most patients (52/57; 91%) had SA densities of > 300 colony-forming units/cm(2) . Colonization rates with SA significantly increased with increasing age (Spearman correlation coefficient R = 0.9, P < 0.05) and increasing duration of lesions in patients with AD (Spearman R = 0.87, P < 0.05). Isolates from eight patients (13.5%) were found to be methicillin-resistant S. aureus (MRSA). Only 6 isolates (10%) were susceptible to penicillin and 22 (37%) to erythromycin, while 28 (47%) isolates had erythromycin-induced resistance to clindamycin. CONCLUSIONS:SA colonization rates were significantly associated with increasing age and severity of AD, and particularly with duration of lesions. Patients with severe disease were also more likely to be colonized with SA strains resistant to conventional antibiotics.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Gomes PL,Malavige GN,Fernando N,Mahendra MH,Kamaladasa SD,Seneviratne JK,Karunatilaka DH,Ogg GSdoi
10.1111/j.1365-2230.2010.03962.xsubject
Has Abstractpub_date
2011-03-01 00:00:00pages
195-200issue
2eissn
0307-6938issn
1365-2230journal_volume
36pub_type
杂志文章abstract::Systemic sclerosis (SSc) is often complicated by severe skin ulcers that are unresponsive to traditional treatments. Vascular alterations are responsible for the ischaemic features of the disease in both the skin and visceral organs. Defective neoangiogenesis correlates with an abnormally reduced quantity of circulati...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2010.03847.x
更新日期:2010-12-01 00:00:00
abstract::Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare lichenoid dermatosis defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of horny follicular papules variously located. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed an...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2001.00881.x
更新日期:2001-09-01 00:00:00
abstract::Myiasis is a condition resulting from the invasion of tissues or organs of man or animals by the larvae of dipterous flies. The distribution of myiasis is worldwide, with more cases being reported from tropical, subtropical, and warm temperate areas. The various forms of myiasis may be classified from an entomological...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1999.00479.x
更新日期:1999-07-01 00:00:00
abstract::Blistering distal dactylitis (BDD) manifests as acral oval bullae 10-30 mm in diameter, and is caused by infection with Gram-positive bacteria. BDD was first linked to infection with group A beta-haemolytic streptococcus in children, but has more recently linked to Staphylococcus aureus and noted in adults. BDD most c...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2007.02379.x
更新日期:2007-05-01 00:00:00
abstract::A case of pure non-epidermotropic cutaneous lymphoma in a human immunodeficiency virus-infected patient is reported following a viral opportunistic infection [cytomegalovirus (CMV) hepatitis]. The lymphoid infiltrate was Epstein-Barr virus and CMV negative with a CD30-positive T-cell phenotype. Molecular analysis demo...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:
更新日期:1997-11-01 00:00:00
abstract::We report a patient with purely cutaneous Rosai-Dorfman disease (RDD) who presented with a solitary, asymptomatic plaque on the back of her left thigh, with characteristic, large histiocytoid cells exhibiting emperipolesis histologically. Cutaneous lesions occur in 27% of patients with lymph node involvement in RDD ho...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1998.00312.x
更新日期:1998-01-01 00:00:00
abstract::Erythema multiforme (EM) is a common, self-limiting condition. Recurrent EM is a well-recognised variant, often associated with herpes simplex virus infection. It is frequently managed with prophylactic aciclovir. Anecdotal reports suggest that recurrent EM may be associated with the use of corticosteroids. Persistent...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12243
更新日期:2014-03-01 00:00:00
abstract::COVID-19 is an infectious disease caused by severe acute respiratory coronavirus 2 (SARS-CoV-2). Vesicular skin rashes have been reported as associated with COVID-19, but there is little information about this cutaneous manifestation. We designed a prospective observational study of patients diagnosed with COVID-19 wh...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.14277
更新日期:2020-10-01 00:00:00
abstract::Thalidomide has been used as an effective treatment for prurigo nodularis (PN) with a median dose of 200 mg, but the risk of peripheral neuropathy precludes long-term use. We analysed the efficacy of low-dose thalidomide (< 100 mg) in 17 patients with recalcitrant PN. Patients were initiated on thalidomide 50 mg on al...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.14015
更新日期:2020-01-01 00:00:00
abstract::Four children affected by intradermal vascular proliferations are presented. The clinicopathological findings closely resemble those of cases described as angioblastoma, a familiar entity in the Japanese literature. Some people suggest that angioblastoma is the same as the tufted angioma described by Wilson-Jones. We ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.1991.tb00318.x
更新日期:1991-03-01 00:00:00
abstract::Previous studies on the association of smoking with acne vulgaris have reported conflicting results. The objective of this study was to investigate such an association. Our setting was three primary care practices in Hong Kong and one primary care practice in India. Patient characteristics in all four practices are si...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1365-2230.2004.01646.x
更新日期:2004-11-01 00:00:00
abstract:BACKGROUND:Immune reconstitution inflammatory syndrome (IRIS) occurs in 10-25% of unselected patients starting highly active antiretroviral therapy (HAART). About 52-78% of these cases involve cutaneous features. AIM:To describe the prevalence and incidence of new dermatological conditions within 6 months of patients ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03620.x
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:Several studies have shown that in Africa squamous cell carcinoma (SCC) is commoner than other skin malignancies. The risk factors are grouped generally into solar and nonsolar factors and their contributions vary with race, geographical region and site of lesion. This study attempted to identify risk factor...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03243.x
更新日期:2009-12-01 00:00:00
abstract::The precursor protein proopiomelanocortin (POMC) produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin. The gene for alpha-MSH is encoded for by the POMC gene, but alpha-MSH c...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2006.02128.x
更新日期:2006-05-01 00:00:00
abstract::Dermanyssus gallinae is a mite that normally parasitizes small birds but may occasionally bite humans. We report an unusual case of an 82-year-old woman who presented with pruritus and bite-like lesions over her trunk. Other members of the household were also affected. On physical examination, mites < 1 mm in size wer...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2012.04434.x
更新日期:2013-06-01 00:00:00
abstract::Although surgery may be curative in early malignant melanoma, its effect on survival lessens with each succeeding stage of the disease. A wide variety of immunological strategies have therefore been used to improve the prognosis of patients with malignant melanoma, but adjuvant therapy with interferon (IFN)-alpha is t...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1365-2230.2000.00559.x
更新日期:2000-01-01 00:00:00
abstract::Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onse...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2230.2004.01438.x
更新日期:2004-01-01 00:00:00
abstract::We report a case of localized bullous pemphigoid (BP) in a woman patient with primary lymphoedema tarda. There is only one previous case reported of localized pemphigoid in an area of lymphoedema, this being of the cicatricial variant. Slow circulation in the lymphatic vessels, increased capillary permeability with pr...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03722.x
更新日期:2009-12-01 00:00:00
abstract::Waldenström macroglobulinaemia (WM) is a chronic lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraprotein. Specific cutaneous features of WM include neoplastic cell infiltrates, IgM storage papules and IgM bullous dermatosis. We report a patient with subepidermal bullous disease assoc...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12166
更新日期:2013-12-01 00:00:00
abstract::Xanthomas are important clinical manifestations of disordered lipid metabolism, which are mostly found in patients with familial hypercholesterolaemia (FH), an inherited disorder that is predominantly caused by mutations in the low-density lipoprotein receptor gene (LDLR). Tuberous and tendinous xanthomas with wide di...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12644
更新日期:2015-10-01 00:00:00
abstract::Polymorphisms of the IL-10 promoter have been implicated in the genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single-nucleotide polymorphisms (SNPs) within the interleukin-10 promoter region (-3575T/A, -2763A/C, -1082G/A and -592C/A) were analysed in 139 patients wit...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2007.02628.x
更新日期:2008-03-01 00:00:00
abstract::This randomized double-blind controlled study examined whether sulphydryl-containing agents influence the healing of venous ulceration occurring for the first time on the medial side of the leg. Graduated compression bandaging, which exerted a mean ankle pressure of 40.6 +/- 0.4 mmHg, and a mean below-knee pressure of...
journal_title:Clinical and experimental dermatology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1365-2230.1992.tb00252.x
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND:Recently, a new population of IL-17-producing CD4 T helper (Th) cells, named Th17, was identified and shown to be involved in various inflammatory and autoimmune diseases, including psoriasis. AIM:To determine the frequency of Th17 cells and related cytokines in peripheral blood of patients with psoriasis, ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/ced.12845
更新日期:2016-10-01 00:00:00
abstract::Rapp-Hodgkin syndrome (RHS) is an autosomal dominant disorder characterized by ectodermal dysplasia and cleft lip/cleft palate. Very recently, mutations in p63 have been identified as a cause of RHS; to date five such mutations have been identified. We describe a Thai girl with RHS. She had short stature, ectodermal d...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2005.01722.x
更新日期:2005-05-01 00:00:00
abstract:BACKGROUND:Port-wine stains (PWS) are congenital capillary malformations that persist throughout life. Laser therapy is a common treatment for PWS, and pulsed-dye laser is the current treatment of choice. AIM:To compare the clinical results on untreated PWS of two dye lasers with different wavelengths and pulse durati...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03399.x
更新日期:2010-03-01 00:00:00
abstract::Photodynamic therapy (PDT) with topical 5-aminolaevulinic acid (5-ALA) is a promising new treatment for superficial malignant nonmelanoma tumours, including cutaneous malignant lymphoma. Here, we report a case of cutaneous anaplastic large cell lymphoma effectively treated by PDT with topical 5-ALA in combination with...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2004.01448.x
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance. AIM:The aim of our study was to analyse the results obtained with a novel autologous cell-h...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2009.03728.x
更新日期:2010-10-01 00:00:00
abstract::Melioidosis is a rare tropical disease caused by infection with the bacterium Burkholderia pseudomallei. It occurs predominantly in south-east Asia, northern and central Australia and central and south America. Patients often present to the internal medicine physicians with a severe, potentially fatal sepsis. We repor...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.2002.01021.x
更新日期:2002-06-01 00:00:00
abstract::Granuloma annulare and localized morphoea are both well described in the dermatological literature. We now present two patients with both of these diseases, a comorbidity rarely described. A possible pathogenic relationship is discussed. ...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1046/j.1365-2230.1999.00425.x
更新日期:1999-03-01 00:00:00
abstract::We report a patient of Malay ancestry with dermatopathia pigmentosa reticularis (DPR) resulting from a recurrent KRT14 p.R125C mutation. The patient has reticulate hyperpigmentation over his trunk and proximal limbs, together with onychodystrophy. Despite the absence of noncicatricial alopecia, he has acral nonscarrin...
journal_title:Clinical and experimental dermatology
pub_type: 杂志文章
doi:10.1111/j.1365-2230.2008.02950.x
更新日期:2009-04-01 00:00:00