Localized bullous pemphigoid in a patient with primary lymphoedema tarda.

Abstract:

:We report a case of localized bullous pemphigoid (BP) in a woman patient with primary lymphoedema tarda. There is only one previous case reported of localized pemphigoid in an area of lymphoedema, this being of the cicatricial variant. Slow circulation in the lymphatic vessels, increased capillary permeability with preferential localization of antibodies in the area, and potential cleavage of the epidermal junction due to increased hydrostatic pressure leading to autoimmunity, have all been advocated as possible pathogenic mechanisms. Nevertheless, we consider that the mechanism by which localized pemphigoid arises on lymphoedema remains elusive, based on a previous case of generalized BP sparing an area of postsurgical lymphoedema.

journal_name

Clin Exp Dermatol

authors

Perez A,Clements SE,Benton E,Robson A,Bhogal B,Stefanato CM,McGibbon D

doi

10.1111/j.1365-2230.2009.03722.x

subject

Has Abstract

pub_date

2009-12-01 00:00:00

pages

e931-3

issue

8

eissn

0307-6938

issn

1365-2230

pii

CED3722

journal_volume

34

pub_type

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