Extensive spinal hyperostosis in a patient receiving isotretinoin--progression after 4 years of etretinate therapy.

Abstract:

:A patient with Darier's disease was discovered to have persistent, asymptomatic cervical and thoracic spinal hyperostoses after receiving isotretinoin for 7 years. The spinal abnormalities have remained asymptomatic but have now progressed following 4 years of etretinate therapy. The development of skeletal abnormalities, in particular spinal hyperostosis, is well-documented in patients receiving the synthetic retinoid, isotretinoin (Accutane, Roaccutane). The occurrence of extraspinal tendon and ligament calcification has been emphasized following long-term therapy with etretinate (Tegison, Tigason), but the relationship between etretinate and spinal hyperostosis is less certain, there being a need for a long-term, prospective, appropriately controlled investigation of patients receiving etretinate. We report a patient with Darier's disease who was discovered to have prominent, asymptomatic cervical and thoracic spinal hyperostoses after receiving isotretinoin for 7 years. Subsequent treatment with etretinate for 4 years did not prevent progression of the spinal abnormalities.

journal_name

Clin Exp Dermatol

authors

Archer CB,Elias PM,Lowe NJ,Griffiths WA

doi

10.1111/j.1365-2230.1989.tb01993.x

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

319-21

issue

4

eissn

0307-6938

issn

1365-2230

journal_volume

14

pub_type

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