Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors.

abstract：:We report the case of a 24-year-old woman with an 8-month history of deep pelvic pain and postcoital bleeding. Examination revealed desquamation of the vaginal epithelium with tender fissured plaques in the vagina, initially thought to be vaginal intraepithelial neoplasia. Histology showed squamous mucosa with supraba...

journal_title：Clinical and experimental dermatology

authors： Kentley J,Cerio R,Khorshid M,Gibbon K

更新日期：2017-03-01 00:00:00

abstract：:A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining. The material showed positive labelling with an antikeratin monoclonal antibody consistent with the proposed origin of the amyloid as degener...

journal_title：Clinical and experimental dermatology

authors： Speight EL,Milne DS,Lawrence CM

更新日期：1993-05-01 00:00:00

abstract：:We present two patients who developed pseudoporphyria whilst taking isotretinoin (Roaccutane). At that time, both patients were receiving other agents which could be incriminated as causing their pseudoporphyria. However, it is significant that these other agents had been longstanding and that the porphyria-like cutan...

journal_title：Clinical and experimental dermatology

authors： Riordan CA,Anstey A,Wojnarowska F

更新日期：1993-01-01 00:00:00

abstract：:A 23-year-old woman presented with a 10 year history of excessive sweating (hyperhidrosis), mostly in the axillae, and to a lesser extent the groin and hands. Initial treatment with a sedative antihistamine and topical Driclor (aluminium chloride hexahydrate in 2% alcohol) for 14 weeks resulted in no improvement. Axil...

journal_title：Clinical and experimental dermatology

authors： Payne CM,Doe PT

更新日期：1998-01-01 00:00:00

abstract：:Longitudinal splitting of the nails can occur as a result of any growth arising in the nail matrix. We present a case of a 50-year-old woman who presented with an 18-month history of longitudinal splitting of the nail on her right little finger, along with pain in the proximal nail fold region, which was extremely ten...

journal_title：Clinical and experimental dermatology

authors： Jha AK,Sinha R,Kumar A,Bhadani P,Kumar S

更新日期：2016-10-01 00:00:00

abstract：:Three cases of chondrodermatitis nodularis helicis (CDNH) in patients with the limited form of systemic sclerosis are described. Two of the three cases were noted during regular follow-up visits and the third case was found as part of a survey of the 21 other patients with systemic sclerosis routinely seen in the depa...

journal_title：Clinical and experimental dermatology

authors： Bottomley WW,Goodfield MD

更新日期：1994-05-01 00:00:00

abstract：:Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases ...

journal_title：Clinical and experimental dermatology

authors： McKenna DB,Cooper EJ,Kavanagh GM,Davie RM,McLaren KM,Tidman MJ

更新日期：2000-11-01 00:00:00

abstract：:Immunosuppression is recognized to predispose to the development of disseminated superficial actinic porokeratosis and to cause the spread of pre-existing lesions. Porokeratosis of Mibelli has been less frequently described following immunosuppression and we report a further case. ...

journal_title：Clinical and experimental dermatology

authors： Wilkinson SM,Cartwright PH,English JS

更新日期：1991-01-01 00:00:00

abstract：:Four patients presenting with chronic pigmented purpuric dermatosis (CPPD) on the limbs were found to have granulomatous inflammation superimposed on the pathological changes of CPPD. Three of the four patients had hyperlipidaemia. Therefore, the granulomatous reaction observed could be associated with hyperlipidaemia...

journal_title：Clinical and experimental dermatology

authors： Lin WL,Kuo TT,Shih PY,Lin WC,Wong WR,Hong HS

更新日期：2007-09-01 00:00:00

abstract：:The disaccharide content of the chondroitinase-digestible glycosaminoglycans (GAGs) extracted from 6-mm skin punch biopsies from the atrophic and sclerotic skin of two patients with Werner's syndrome (WS) were determined using high-performance liquid chromatography after 1-phenyl-3-methyl-5-pyrazolone labelling. The t...

journal_title：Clinical and experimental dermatology

authors： Higuchi T,Ishikawa O,Hayashi H,Ohnishi K,Miyachi Y

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Tinea unguium is a dermatophyte infection of the nails. Itraconazole is a broad-spectrum antifungal drug used to treat this disease. It works by interfering with the synthesis of ergosterol in the cell membrane, thus causing changes that can be seen under scanning electron microscopy (SEM). AIM:To observe u...

journal_title：Clinical and experimental dermatology

authors： Yue X,Wang A,Sun Y,Li Q

更新日期：2018-12-01 00:00:00

abstract：:Cutaneous amyloidosis and multiple endocrine neoplasia 2A (MEN 2A) have been previously reported in several families. A genetic linkage of both disorders has recently been described. Notalgia paraesthetica has been suggested to be involved in the aetiology of amyloidosis in such patients. We report such an association...

journal_title：Clinical and experimental dermatology

authors： de Argila D,Ortiz-Romero PL,Ortiz-Frutos J,Rodriguez-Peralto JL,Iglesias L

更新日期：1996-07-01 00:00:00

abstract：BACKGROUND:Reactive oxygen species (ROS) contribute to the cell dysfunction and tissue damage that result from glucolipotoxicity in diabetes. ROS formation in cells causes oxidative stress, thereby activating oxidative damage-inducing genes. Nuclear factor erythroid 2-related factor 2 (Nrf2) has been shown to play an e...

journal_title：Clinical and experimental dermatology

authors： Lee YJ,Kwon SB,An JM,Kim CH,Lee SH,Choi CY,Nam DH,Park JW,Nam HS,Lee SH,Lee MW,Cho MK

更新日期：2015-03-01 00:00:00

abstract：:A case of disseminated Kaposi sarcoma in a 76-year-old woman treated with low-dose steroids for a seronegative polyarthritis is described. HIV serology was negative, whereas PCR for HHV-8 was positive. The patient presented with a profound reduction in the peripheral blood CD4+ cell count and a decrease in serum immun...

journal_title：Clinical and experimental dermatology

authors： Fierro MT,Savoia P,Quaglino P,Novero D,Bernengo MG

更新日期：2005-07-01 00:00:00

abstract：:An essential property of the immune system is its ability to generate diverse antibody and T-cell mediated responses to virtually any potential foreign particle. The basic molecular mechanisms responsible for producing this extensive diversity have now been elucidated. Each T cell expresses a unique membrane bound T-c...

journal_title：Clinical and experimental dermatology

authors： Whittaker S

更新日期：1996-03-01 00:00:00

abstract：BACKGROUND:The protein kynureninase (KYNU) has recently been reported to participate in the pathological processes of various diseases. AIM:To explore the expression and the biological function of KYNU in cutaneous squamous cell carcinoma (cSCC). METHODS:Expression of KYNU in cSCC cell lines and tissues was firstly e...

journal_title：Clinical and experimental dermatology

authors： Ci C,Wu C,Lyu D,Chang X,He C,Liu W,Chen L,Ding W

更新日期：2020-03-01 00:00:00

abstract：:Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

journal_title：Clinical and experimental dermatology

authors： Patel AN,Cohen SN,Leach IH,Scharrer K

更新日期：2012-04-01 00:00:00

abstract：BACKGROUND:Vitiligo is a pigmentation disorder of autoimmune aetiology. Polymorphisms in beta-defensin genes have been linked to a predisposition to some autoimmune disorders. AIM:To evaluate the role of polymorphisms in DEFB1, the gene encoding for human beta-defensin (HBD)-1 and its 5' untranslated region in nonsegm...

journal_title：Clinical and experimental dermatology

authors： Ochoa-Ramírez LA,Becerra-Loaiza DS,Díaz-Camacho SP,Muñoz-Estrada VF,Ríos-Burgueño ER,Prado-Montes de Oca E,Rangel-Villalobos H,Velarde-Félix JS

更新日期：2019-04-01 00:00:00

abstract：:Granuloma annulare and localized morphoea are both well described in the dermatological literature. We now present two patients with both of these diseases, a comorbidity rarely described. A possible pathogenic relationship is discussed. ...

journal_title：Clinical and experimental dermatology

authors： Ben-Amitai D,Hodak E,Lapidoth M,David M

更新日期：1999-03-01 00:00:00

abstract：:Myiasis is a condition resulting from the invasion of tissues or organs of man or animals by the larvae of dipterous flies. The distribution of myiasis is worldwide, with more cases being reported from tropical, subtropical, and warm temperate areas. The various forms of myiasis may be classified from an entomological...

journal_title：Clinical and experimental dermatology

authors： Delir S,Handjani F,Emad M,Ardehali S

更新日期：1999-07-01 00:00:00

abstract：:Treatment of autoimmune blistering diseases consists of systemic glucocorticosteroids usually in combination with additional immunosuppressants such as azathioprine and mycophenolate mofetil or immunomodulators such as dapsone, antibiotics, intravenous immunoglobulins, and immunoadsorption. In some patients, these tre...

journal_title：Clinical and experimental dermatology

authors： Schmidt E,Hunzelmann N,Zillikens D,Bröcker EB,Goebeler M

更新日期：2006-07-01 00:00:00

abstract：:We report a 73-year-old man who developed repeated episodes of erythematous, bullous plaques beginning 3 months after discontinuation of combination treatment with pegylated interferon (IFN)-alpha-2b and ribavirin for hepatitis C virus infection. The first episode resolved within a week without treatment, but the lesi...

journal_title：Clinical and experimental dermatology

authors： Sato M,Sueki H,Iijima M

更新日期：2009-12-01 00:00:00

abstract：:This article forms part of a series of annual updates that summarizes the evidence base for atopic eczema (AE). It provides a summary of key findings from 28 systematic reviews that were published or indexed during 2017, and focuses on the epidemiology, aetiology and risk factors of AE. AE is the largest single contri...

journal_title：Clinical and experimental dermatology

authors： Hale G,Davies E,Grindlay DJC,Rogers NK,Harman KE

更新日期：2019-12-01 00:00:00

abstract：:Palmoplantar punctate keratoses may be the main cutaneous sign of various diseases (porokeratosis punctata palmaris et plantaris, keratosis punctata of the palmar creases, familial punctate palmoplantar keratoderma) or represent a secondary feature [Cowden's syndrome (CS) and Darier's disease]. In CS, such keratoses u...

journal_title：Clinical and experimental dermatology

authors： Ferran M,Bussaglia E,Matias-Guiu X,Pujol RM

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Psoriasis is a common chronic inflammatory skin disease caused by genetic and epigenetic factors. There are conflicting results in the literature about the association between psoriasis and the methylenetetrahydrofolate reductase gene (MTHFR), ranging from strong linkage to no association. AIM:To investigat...

journal_title：Clinical and experimental dermatology

authors： Kilic S,Ozdemir O,Silan F,Isik S,Yildiz O,Karaagacli D,Silan C,Ogretmen Z

更新日期：2017-01-01 00:00:00

abstract：:Amyopathic dermatomyositis (ADM) is characterized clinically by typical skin lesions with hypomyopathy or no muscular involvement. ADM has been recently reported to be complicated by rapidly progressive interstitial lung disease (ILD), especially in patients with positive antibodies against melanoma differentiation-as...

journal_title：Clinical and experimental dermatology

authors： Molina-Ruiz AM,Romero F,Carrasco L,Feltes F,Haro R,Requena L

更新日期：2015-12-01 00:00:00

abstract：:Ichthyosis hystrix, Curth-Macklin type (IHCM) is an extremely rare autosomal dominant dermatosis caused by mutations in the keratin genes, KRT1 or KRT10, which often manifests as extensive, dark, spiky or verrucous plaques and severe palmoplantar keratoderma. We report a novel frameshift truncation mutation, c.1596_15...

journal_title：Clinical and experimental dermatology

authors： Yang Z,Xu Z,Zhang N,Ma L

更新日期：2020-08-01 00:00:00

abstract：:We report a case of localized bullous pemphigoid (BP) in a woman patient with primary lymphoedema tarda. There is only one previous case reported of localized pemphigoid in an area of lymphoedema, this being of the cicatricial variant. Slow circulation in the lymphatic vessels, increased capillary permeability with pr...

journal_title：Clinical and experimental dermatology

authors： Perez A,Clements SE,Benton E,Robson A,Bhogal B,Stefanato CM,McGibbon D

更新日期：2009-12-01 00:00:00

abstract：:We report a case of follicular porokeratosis of Mibelli affecting the natal cleft in a 42-year-old white man. To our knowledge, this is the first report in the English-language literature of follicular porokeratosis of Mibelli limited to the genitogluteal area. ...

journal_title：Clinical and experimental dermatology

authors： Yong AS,Singh M,Goulding JM,Swale VJ

更新日期：2009-01-01 00:00:00

abstract：:We present a case of neonatal lupus erythematosus (NLE) in a black infant presenting with symmetrical depigmented macules on the face resembling vitiligo. NLE is a rare condition affecting newborn infants of mothers who have connective tissue disease, with or without autoantibodies to extractable nuclear antigens Ro (...

journal_title：Clinical and experimental dermatology

authors： Jenkins RE,Kurwa AR,Atherton DJ,Black MM

更新日期：1994-09-01 00:00:00