Role of serum 25-hydroxyvitamin D levels and vitamin D receptor gene polymorphisms in patients with rosacea: a case-control study.

Abstract:

BACKGROUND:Vitamin D has significant effects on the immune system and thereby on the pathogenesis of rosacea. However, there is a lack of information on the vitamin D status and vitamin D receptors (VDRs) of patients with rosacea. AIM:To evaluate the role of vitamin D in rosacea susceptibility. METHODS:A case-control study was conducted, enrolling patients with rosacea and healthy controls (HCs). Five VDR gene single nucleotide polymorphisms (SNPs) (Cdx2, FokI, ApaI, BsmI and TaqI) and serum 25-hydroxyvitamin D3 [25(OH)D3 ] levels were compared between patients and HCs. RESULTS:The study enrolled 60 patients (M/F: 14/46) and 60 age- and sex-matched HCs (M/F: 14/46). Age (mean ± SD) was 48 ± 11 years for both groups. The serum 25(OH)D3 levels (median ± interquartile range) were higher in patients with rosacea (12.9 ± 6.8 ng/mL) than in HCs (10.5 ± 3.7 ng/mL) (P < 0.001). Subjects with high serum 25(OH)D3 levels had a 1.36-fold increased risk of rosacea (95% CI 1.17-1.58). Heterozygous and mutant ApaI polymorphisms increased rosacea risk by 5.26-fold (95% CI 1.51-18.35) and 3.69-fold (95% CI 1.19-11.48), respectively, whereas mutant TaqI polymorphisms decreased the risk by 4.69 times (95% CI 1.37-16.67). Heterozygosity for Cdx2 alleles increased rosacea risk, whereas wildtype ApaI and mutant TaqI alleles decreased it. CONCLUSIONS:The present study suggests that an increase in vitamin D levels may contribute to the development of rosacea. ApaI and TaqI polymorphisms, and heterozygous Cdx2, wildtype ApaI and mutant TaqI alleles were significantly associated with rosacea. These results indicate a possible role of vitamin D and VDR pathways in the pathogenesis of rosacea, although causality could not be assessed.

journal_name

Clin Exp Dermatol

authors

Akdogan N,Alli N,Incel Uysal P,Candar T

doi

10.1111/ced.13769

subject

Has Abstract

pub_date

2019-06-01 00:00:00

pages

397-403

issue

4

eissn

0307-6938

issn

1365-2230

journal_volume

44

pub_type

杂志文章
  • The finger-tip unit--a new practical measure.

    abstract::A finger-tip unit (FTU) is the amount of ointment expressed from a tube with a 5 mm diameter nozzle, applied from the distal skin-crease to the tip of the index finger. Thirty adult-patients treated various anatomical regions using FTU's of ointment. The number of FTU's required was: face and neck 2.5 (s.d. +/- 0.8); ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1991.tb01232.x

    authors: Long CC,Finlay AY

    更新日期:1991-11-01 00:00:00

  • Lichen planopilaris in a Latin American (Chilean) population: demographics, clinical profile and treatment experience.

    abstract:BACKGROUND:Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM:To analyse epidemiological data and clinical profiles of Chile...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.13203

    authors: Mardones F,Shapiro J

    更新日期:2017-10-01 00:00:00

  • Drug-induced subacute cutaneous lupus erythematosus associated with omeprazole.

    abstract::Subacute cutaneous lupus erythematosus (SCLE) is characterized by annular scaly erythematous plaques in a photosensitive distribution, and the presence of anti-Ro (SSA) and/or anti-La (SSB) antibodies. Most cases of SCLE are idiopathic, but occasional cases may be drug-induced or associated with a hereditary deficienc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2010.03926.x

    authors: Toms-Whittle LM,John LH,Buckley DA

    更新日期:2011-04-01 00:00:00

  • Seven novel COL7A1 mutations identified in patients with recessive dystrophic epidermolysis bullosa from Mexico.

    abstract::Recessive dystrophic epidermolysis bullosa (RDEB; OMIM #226600) is one of the most devastating subtypes of epidermolysis bullosa, a group of skin and mucous membrane blistering disorders often associated with extracutaneous manifestations. RDEB is caused by mutations in COL7A1, the gene encoding type VII collagen (C7)...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.13407

    authors: Saeidian AH,Youssefian L,Moreno Trevino MG,Fortuna G,Vahidnezhad H,Atanasova VS,Uitto J,Salas-Alanis JC,South AP

    更新日期:2018-07-01 00:00:00

  • Actinic comedonal plaque--a rare ectopic form of the Favre-Racouchot syndrome.

    abstract::A 59-year-old woman with a single cuff-like plaque, consisting of multiple skin-coloured to bluish cysts and comedones on her right forearm is reported. The solitary lesion resembled, morphologically and histologically, the Favre-Racouchot syndrome. The above condition is another case of the previously described actin...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1993.tb02181.x

    authors: John SM,Hamm H

    更新日期:1993-05-01 00:00:00

  • Familial Jessner's lymphocytic infiltration of the skin, occurring in a father and daughter.

    abstract::Familial occurrence of Jessner's lymphocytic infiltration of the skin is reported in a father and daughter. A definitive diagnosis of Jessner's disease was greatly facilitated by the presence of large numbers of plasmacytoid monocytes within the dermal infiltrates in both patients. A role for skin-directed lymphocyte ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1993.tb00996.x

    authors: Toonstra I,van der Putte SC,de la Faille HB,van Vloten WA

    更新日期:1993-03-01 00:00:00

  • Leukonychia due to cytostatic agents.

    abstract::Chromonychia induced by antineoplastic agents has been known for several years. The most frequent of these is melanonychia, either diffuse or in tranverse or longitudinal bands, that may co-exist with diffuse pigmentation of the skin. Although any cytostatic agent may be involved in melanonychia, this condition appear...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1992.tb02166.x

    authors: Unamuno P,Fernández-López E,Santos C

    更新日期:1992-07-01 00:00:00

  • Allergic airborne contact dermatitis from essential oils used in aromatherapy.

    abstract::Contact allergy to various essential oils used in aromatherapy was demonstrated on patch testing in a 53-year-old patient suffering from relapsing eczema resistant to therapy on various uncovered parts of the skin, in particular the scalp, neck and hands. Sensitization was due to previous exposure to lavender, jasmine...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1995.tb02719.x

    authors: Schaller M,Korting HC

    更新日期:1995-03-01 00:00:00

  • Angioblastoma (Nakagawa)--is it the same as tufted angioma?

    abstract::Four children affected by intradermal vascular proliferations are presented. The clinicopathological findings closely resemble those of cases described as angioblastoma, a familiar entity in the Japanese literature. Some people suggest that angioblastoma is the same as the tufted angioma described by Wilson-Jones. We ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1991.tb00318.x

    authors: Cho KH,Kim SH,Park KC,Lee AY,Song KY,Chi JG,Lee YS,Kim KJ

    更新日期:1991-03-01 00:00:00

  • Role of fibroblast-derived factors in the pathogenesis of melasma.

    abstract:BACKGROUND:The hyperactive melanocytes present in melasma skin are confined to the epidermis, but epidermal ablation to treat melasma pigmentation may lead to disease recurrence and aggravation. Melanocyte function is regulated by interactions between melanocytes and neighbouring cells such as keratinocytes and fibrobl...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12874

    authors: Byun JW,Park IS,Choi GS,Shin J

    更新日期:2016-08-01 00:00:00

  • Lichenoid keratosis is frequently misdiagnosed as basal cell carcinoma.

    abstract::Lichenoid keratosis (LK), also known as benign lichenoid keratosis or lichen planus-like keratosis, is a solitary, pink to red-brown scaly plaque representing a host immunological response to a variety of precursor lesions. LK is often misdiagnosed as a dermatological malignancy owing to its clinical resemblance to ba...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.13178

    authors: Maor D,Ondhia C,Yu LL,Chan JJ

    更新日期:2017-08-01 00:00:00

  • Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod.

    abstract::Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of sq...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2008.02938.x

    authors: Erkek E,Basar H,Bozdogan O,Emeksiz MC

    更新日期:2009-04-01 00:00:00

  • The association of smoking and acne in men in Hong Kong and in India: a retrospective case-control study in primary care settings.

    abstract::Previous studies on the association of smoking with acne vulgaris have reported conflicting results. The objective of this study was to investigate such an association. Our setting was three primary care practices in Hong Kong and one primary care practice in India. Patient characteristics in all four practices are si...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2230.2004.01646.x

    authors: Chuh AA,Zawar V,Wong WC,Lee A

    更新日期:2004-11-01 00:00:00

  • Mohs' micrographic surgery for basal cell carcinoma.

    abstract::Mohs' surgery for basal cell carcinoma (BCC) is widely recommended by dermatologists as first line surgical therapy for recurrent or ill-defined skin tumours. The technique assumes that BCC spread by contiguous growth and that all tumour cells have to be removed. Advocates claim that Mohs' surgery provides a better ch...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2230.1999.00433.x

    authors: Lawrence CM

    更新日期:1999-03-01 00:00:00

  • Polymorphic eruption of pregnancy developing in the puerperium.

    abstract::Polymorphic eruption of pregnancy is an uncommon disorder, usually developing in the third trimester and rapidly resolving in the first few weeks postpartum. It has been suggested that multiple pregnancy and excessive weight gain are associated features. We report a patient with the clinical and histological features ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2002.01099.x

    authors: Kirkup ME,Dunnill MG

    更新日期:2002-11-01 00:00:00

  • Encephalocraniocutaneous lipomatosis (Haberland syndrome) with bilateral cutaneous and visceral involvement.

    abstract::Encephalocraniocutaneous lipomatosis, or Haberland syndrome, is a rare congenital neurocutaneous disease. It is characterized clinically by unilateral lipomatous hamartomata of the scalp, eyelid, and outer globe of the eye, ipsilateral porencephalic cysts with cortical atrophy, cranial asymmetry, marked developmental ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2003.01329.x

    authors: Rubegni P,Risulo M,Sbano P,Buonocore G,Perrone S,Fimiani M

    更新日期:2003-07-01 00:00:00

  • A trial of accelerated PUVA in psoriasis.

    abstract::Ten psoriatic patients were treated with an accelerated PUVA regimen. Nine patients cleared in an average of 13.7 treatments (range 4-24) after an average total UVA dose of 83 J/cm2 (range 18-186). One patient had to withdraw due to pruritus and burning and six others had burning problems. The high incidence of burnin...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1993.tb02201.x

    authors: Green C,George S,Lakshmipathi T,Ferguson J

    更新日期:1993-07-01 00:00:00

  • Intravenous cidofovir for resistant cutaneous warts in a patient with psoriasis treated with monoclonal antibodies.

    abstract::Human papilloma virus is a common and often distressing cutaneous disease. It can be therapeutically challenging, especially in immunocompromised patients. We report a case of recalcitrant cutaneous warts that resolved with intravenous cidofovir treatment. The patient was immunocompromised secondary to monoclonal anti...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2011.04039.x

    authors: McAleer MA,Bourke J

    更新日期:2011-08-01 00:00:00

  • Acute generalized exanthematous pustulosis induced by itraconazole: an immunological approach.

    abstract::Acute generalized exanthematous pustulosis (AGEP) is an uncommon disease, which presents as a nonfollicular erythematous sterile pustular eruption. More than 90% of the cases are induced by adverse drug reactions, often triggered by anti-infectious systemic drugs. We report a case of itraconazole-induced AGEP in a 22-...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03440.x

    authors: Cançado GG,Fujiwara RT,Freitas PA,Correa-Oliveira R,Bethony JM

    更新日期:2009-12-01 00:00:00

  • Psychosomatic cofactors and psychiatric comorbidity in patients with chronic itch.

    abstract:BACKGROUND:While psychosomatic factors may be involved in eliciting as well as coping with chronic itch, psychiatric comorbidity often goes unrecognized in dermatological patients. AIM:To record psychiatric illness, psychiatric and psychotherapeutic pretreatment, and psychotherapy indication in dermatology inpatients ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2006.02211.x

    authors: Schneider G,Driesch G,Heuft G,Evers S,Luger TA,Ständer S

    更新日期:2006-11-01 00:00:00

  • The management of cutaneous leishmaniasis from Belize.

    abstract::We report 20 patients who contracted cutaneous leishmaniasis in Central and South America, 18 of them in Belize. The diagnosis was confirmed by the polymerase chain reaction (PCR) in 79% of those tested; the corresponding figure for histology was 62%, touch smear 46%, and culture 11%. Results of PCR can be falsely pos...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2001.00751.x

    authors: Palmer RA,Tran D,Hepburn NC,Ashton RE

    更新日期:2001-01-01 00:00:00

  • DRESS syndrome caused by efalizumab.

    abstract::We report a case of drug reaction with eosinophilia and systemic symptoms (DRESS) to efalizumab. A 52-year-old man developed a widespread papulovesicular rash after 4 weeks of treatment with efalizumab (1.0 mg/kg/week) for treatment-resistant severe psoriasis. Histology revealed a subepidermal blister with eosinophil-...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2007.02604.x

    authors: White JM,Smith CH,Robson A,Ash G,Barker JN

    更新日期:2008-01-01 00:00:00

  • Cutis marmorata telangiectatica congenita: a prospective study of 27 cases and review of the literature with proposal of diagnostic criteria.

    abstract:BACKGROUND:Cutis marmorata telangiectatica congenita (CMTC) is a congenital vascular anomaly of unknown aetiology. About 300 cases have been reported in the literature. The rate of associated anomalies varies between 20% and 70%. METHODS:We report a series of 27 children with CMTC, 18 of whom were followed-up prospect...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2230.2008.03074.x

    authors: Kienast AK,Hoeger PH

    更新日期:2009-04-01 00:00:00

  • Amyophatic dermatomyositis presenting as a flagellated skin eruption with positive MDA5 antibodies and thyroid cancer: a real association?

    abstract::Amyopathic dermatomyositis (ADM) is characterized clinically by typical skin lesions with hypomyopathy or no muscular involvement. ADM has been recently reported to be complicated by rapidly progressive interstitial lung disease (ILD), especially in patients with positive antibodies against melanoma differentiation-as...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12674

    authors: Molina-Ruiz AM,Romero F,Carrasco L,Feltes F,Haro R,Requena L

    更新日期:2015-12-01 00:00:00

  • Extensive naevus comedonicus in a child with Alagille syndrome.

    abstract::Naevus comedonicus is a rare condition, thought to be a hamartoma in which cells of the pilosebaceous unit fail to develop appropriately. Although it is usually an isolated phenomenon, it has been associated with other defects, including those of the skeletal, ocular and central nervous system. A girl with this condit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1994.tb01149.x

    authors: Woods KA,Larcher VF,Harper JI

    更新日期:1994-03-01 00:00:00

  • Pruritus in adult dermatomyositis.

    abstract::Dermatomyositis has a significant clinical component of pruritus that has not yet been studied. Pruritus can significantly affect the life of patients. The aim of the present work was to study the degree of pruritus experienced by patients. A four-question survey was sent to patients with documented dermatomyositis. T...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2004.01510.x

    authors: Shirani Z,Kucenic MJ,Carroll CL,Fleischer AB Jr,Feldman SR,Yosipovitch G,Jorizzo JL

    更新日期:2004-05-01 00:00:00

  • Inflammation of actinic keratoses subsequent to therapy with sorafenib, a multitargeted tyrosine-kinase inhibitor.

    abstract::The Ras-Raf-MEK-ERK signalling pathway is frequently dysregulated in human malignancies, as is angiogenesis and the vascular endothelial growth factor receptor (VEGF/VEGFR) pathway. These kinases are therefore important anticancer targets. The novel, oral treatment sorafenib (BAY 43-9006), has been shown to be an inhi...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2006.02223.x

    authors: Lacouture ME,Desai A,Soltani K,Petronic-Rosic V,Laumann AE,Ratain MJ,Stadler WM

    更新日期:2006-11-01 00:00:00

  • Juvenile colloid milium associated with ligneous conjunctivitis: report of a case and review of the literature.

    abstract::Juvenile colloid milium is an extremely rare skin condition with an onset prior to puberty; it can be distinguished histologically from the adult form. We report a case of juvenile colloid milium associated with ligneous conjunctivitis and gingival deposits of an amyloid-like homogenous eosinophilic material. We hypot...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2230.2000.00597.x

    authors: Chowdhury MM,Blackford S,Williams S

    更新日期:2000-03-01 00:00:00

  • Usefulness of the AMeX method for immunostaining with antikeratin antibodies.

    abstract::We performed an immunohistochemical study with 11 antikeratin antibodies using the newly developed AMeX (acetone-methylbenzoate-xylene) tissue processing method. Specimens processed with this method showed almost as good preservation and morphological detail as routinely processed, formalin-fixed and paraffin-embedded...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1994.tb01247.x

    authors: Ansai SI,Koseki S,Hozumi Y,Kondo S

    更新日期:1994-11-01 00:00:00

  • Verrucous trichilemmal cyst containing human papillomavirus.

    abstract::Verrucous cyst is an uncommon nonplantar epidermoid (infundibular) cyst with verrucous changes in its wall. We present the first case of trichilemmal cyst (isthmus-catagen cyst) with verrucous changes of its squamous lining. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2004.01645.x

    authors: Misago N,Narisawa Y

    更新日期:2005-01-01 00:00:00