Giant condyloma acuminata of Buschke-Löwenstein: successful treatment with a combination of surgical excision, oral acitretin and topical imiquimod.

Abstract:

:Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of squamous cell carcinoma. Various treatments have been used, but response is often poor and recurrence rates high. We present a case of GCA successfully treated with a combination of surgical excision, oral acitretin and topical imiquimod. The diagnosis was based on histological examination, immunohistochemical analysis and in situ hybridization for HPV 6 and 11. We recommend a trial of oral retinoid and topical imiquimod in selected cases of GCA.

journal_name

Clin Exp Dermatol

authors

Erkek E,Basar H,Bozdogan O,Emeksiz MC

doi

10.1111/j.1365-2230.2008.02938.x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

366-8

issue

3

eissn

0307-6938

issn

1365-2230

pii

CED2938

journal_volume

34

pub_type

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