Intercellular IgA dermatosis (IgA pemphigus)--two cases illustrating the clinical heterogeneity of this disorder.

Abstract:

:IgA pemphigus is rare but may be underdiagnosed. We describe two cases, a 50-year-old female with a pustular eruption resembling subcorneal pustular dermatosis and a 55-year-old male with a pruritic vesiculopustular eruption simulating dermatitis herpetiformis. They illustrate the clinical heterogeneity of IgA pemphigus which is likely to reflect differences in autoantigens, analogous to pemphigus vulgaris and pemphigus foliaceus. There is now evidence that IgA pemphigus encompasses at least two subgroups: a subcorneal pustular dermatosis (SPD)-type, (see case 1) characterized by subcorneal pustules and autoantibodies to desmocollin 1; and intra-epidermal neutrophilic dermatosis (IEN)-type cases (see case 2) which show intra-epidermal pustules and in whom the autoantigen may be desmoglein 3, the pemphigus vulgaris antigen.

journal_name

Clin Exp Dermatol

authors

Harman KE,Holmes G,Bhogal BS,McFadden J,Black MM

doi

10.1046/j.1365-2230.1999.00534.x

keywords:

subject

Has Abstract

pub_date

1999-11-01 00:00:00

pages

464-6

issue

6

eissn

0307-6938

issn

1365-2230

pii

ced534

journal_volume

24

pub_type

杂志文章
  • Histopathological study of perilesional skin in patients diagnosed with nonmelanoma skin cancer.

    abstract:BACKGROUND:Epidemiological and clinical data suggest that actinic damage to the skin is an important predictor of skin carcinogenesis. AIM:To investigate the association of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) with sun-damage alterations seen by histopathology. METHOD:In the current prospectiv...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12713

    authors: Apalla Z,Calzavara-Pinton P,Lallas A,Argenziano G,Kyrgidis A,Crotti S,Facchetti F,Monari P,Gualdi G

    更新日期:2016-01-01 00:00:00

  • Acquired cold urticaria: clinical picture and update on diagnosis and treatment.

    abstract::Acquired cold urticaria (ACU) is a frequent subtype of physical urticaria that is caused by the release of proinflammatory mast cell mediators after cold exposure. Although the underlying causes of ACU still remain to be clarified in detail, a wide range of diseases has been reported to be associated with ACU. This re...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2230.2007.02376.x

    authors: Siebenhaar F,Weller K,Mlynek A,Magerl M,Altrichter S,Vieira Dos Santos R,Maurer M,Zuberbier T

    更新日期:2007-05-01 00:00:00

  • The Laugier-Hunziker syndrome--a clinical review of six cases.

    abstract::The Laugier-Hunziker syndrome is an acquired, benign, macular hyperpigmentation of the lips and buccal mucosa. The nails are often involved with the development of melanonychia. Twenty-two previous cases have been recorded in the literature. We present details of six Caucasian patients with the Laugier-Hunziker syndro...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1990.tb02044.x

    authors: Kemmett D,Ellis J,Spencer MJ,Hunter JA

    更新日期:1990-03-01 00:00:00

  • Squamous cell carcinoma arising in a venous ulcer as a complication of the Klippel-Trenaunay syndrome.

    abstract::Klippel-Trenaunay (KT) syndrome is a vascular malformation characterized by a port-wine stain, varicose veins and hypertrophy of the affected limb. Ulceration is considered an uncommon complication of KT syndrome and occurrence of skin cancer has been previously reported only in one case. We observed a case of KT synd...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.2002.01009.x

    authors: De Simone C,Giampetruzzi AR,Guerriero C,De Masi M,Amerio P,Cina G

    更新日期:2002-05-01 00:00:00

  • Specific loss of connexin 26 expression in ductal sweat gland epithelium associated with the deletion mutation del(GJB6-D13S1830).

    abstract::A whole array of cutaneous syndromes is associated with distinct dominant mutations in GJB2 encoding the gap junction protein connexin 26 (C x 26), including Vohwinkel's syndrome and keratitis-ichthyosis-deafness syndrome. In contrast, recessive GJB2 mutations occur in a large proportion of individuals with hearing lo...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2005.01878.x

    authors: Common JE,Bitner-Glindzicz M,O'Toole EA,Barnes MR,Jenkins L,Forge A,Kelsell DP

    更新日期:2005-11-01 00:00:00

  • Naevoid hypertrichosis--report of a patient with multiple lesions.

    abstract::Naevoid hypertrichosis is an unusual congenital disorder consisting of a solitary circumscribed area of terminal hair growth which is not associated with any other systemic abnormalities. We describe a patient with multiple areas of circumscribed naevoid hypertrichosis on the trunk and limbs who also had lipodystrophy...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1989.tb00887.x

    authors: Cox NH,McClure JP,Hardie RA

    更新日期:1989-01-01 00:00:00

  • Famotidine in the treatment of acute urticaria.

    abstract::Recent studies suggest that histamine H2-receptor antagonists may be useful in the treatment of urticaria. This study was conducted to determine whether famotidine, a H2 antagonist, is effective in the treatment of acute urticaria and compare its effect with that of the H1 antagonist diphenhydramine. In this prospecti...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2230.2000.00609.x

    authors: Watson NT,Weiss EL,Harter PM

    更新日期:2000-05-01 00:00:00

  • Johnson square procedure for lentigo maligna and lentigo maligna melanoma.

    abstract:BACKGROUND:Lentigo maligna (LM) and lentigo maligna melanoma (LMM) can be difficult to manage surgically. Predetermined margins can be inadequate because of subclinical spread, or can affect function when margins are adjacent to the eye or mouth. AIM:To describe our 5-year experience in Nottingham of using the staged ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12363

    authors: Patel AN,Perkins W,Leach IH,Varma S

    更新日期:2014-07-01 00:00:00

  • Acquired dermal melanocytosis of the face and extremities.

    abstract::Acquired dermal melanocytosis (ADM) is a relatively rare, but well-described disease among adolescent to middle-aged East Asian women, particularly those of Japanese and Chinese descent. Clinically, ADM manifests as multiple punctate and greyish-brown pigmented areas 1-3 mm in diameter occurring on both sides of the f...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12867

    authors: Ouchi T,Ishii K,Nishikawa T,Ishiko A

    更新日期:2016-08-01 00:00:00

  • Linear lichen planus and lichen striatus--opposite ends of a spectrum.

    abstract::The linear pattern of lichen planus (LP) is extremely rare. In six publications 1256 patients with LP have been reviewed and only three cases of linear LP (LLP) are reported. The differential diagnosis of LLP includes a number of linear dermatoses in particular lichen striatus (LS) and the extent of overlap between th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1993.tb02211.x

    authors: Herd RM,McLaren KM,Aldridge RD

    更新日期:1993-07-01 00:00:00

  • Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology.

    abstract::Controlled trials and clinical experience indicate that systemic cyclosporin A and tacrolimus are effective treatments for psoriasis, and that cyclosporin A also improves atopic eczema. A variety of other inflammatory and non-inflammatory skin diseases are probably also responsive to these drugs. However, the widespre...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2230.2002.01148.x

    authors: Reynolds NJ,Al-Daraji WI

    更新日期:2002-10-01 00:00:00

  • Patients affected by a new variant of endemic pemphigus foliaceus have autoantibodies colocalizing with MYZAP, p0071, desmoplakins 1-2 and ARVCF, causing renal damage.

    abstract:BACKGROUND:We have previously reported that about 30% of patients affected by a new variant of endemic pemphigus foliaceus (EPF) in El Bagre, Colombia (termed El Bagre-EPF or pemphigus Abreu-Manu) have systemic compromise. In the current study, we focused on studying autoreactivity to the kidney and its pathological co...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.13566

    authors: Abreu-Velez AM,Howard MS,Yi H,Florez-Vargas AA

    更新日期:2018-08-01 00:00:00

  • Leucoderma after use of a skin-lightening cream containing kojic dipalmitate, liquorice root extract and Mitracarpus scaber extract.

    abstract::A lighter or whiter complexion is socially desirable in many cultures. This has led to an unregulated and highly profitable market in skin-lightening creams that are readily available over the counter or on the internet. Plant extracts and newer tyrosinase inhibitors such as kojic acid or its derivative kojic dipalmit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03690.x

    authors: Madhogaria S,Ahmed I

    更新日期:2010-06-01 00:00:00

  • Coexisting morphoea and granuloma annulare-are the conditions related?

    abstract::Granuloma annulare and localized morphoea are both well described in the dermatological literature. We now present two patients with both of these diseases, a comorbidity rarely described. A possible pathogenic relationship is discussed. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2230.1999.00425.x

    authors: Ben-Amitai D,Hodak E,Lapidoth M,David M

    更新日期:1999-03-01 00:00:00

  • What's new in atopic eczema? An analysis of systematic reviews published in 2015. Part 1: epidemiology and methodology.

    abstract::This review forms part of a series of annual updates that summarize the evidence base for atopic eczema (AE), providing a succinct guide for clinicians and patients. It provides a summary of key findings from 15 systematic reviews that were published during 2015, and focuses on the epidemiology and methodology issues ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/ced.13377

    authors: Davies E,Rogers NK,Lloyd-Lavery A,Grindlay DJC,Thomas KS

    更新日期:2018-06-01 00:00:00

  • Acneiform follicular mucinosis.

    abstract::Follicular mucinosis is a rare chronic inflammatory disease of unknown aetiology, presenting as mucin deposits around the follicles and sebaceous glands. It can progress to alopecia of the scalp and other hairy areas. Follicular mucinosis may be a benign primary idiopathic disorder or secondary to malignant lymphoprol...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2004.01551.x

    authors: Passaro EM,Silveira MT,Valente NY

    更新日期:2004-07-01 00:00:00

  • Tumoral calcinosis: an unusual cause of cutaneous calcification.

    abstract::Tumoral calcinosis is an uncommon ectopic calcification syndrome characterized clinically by the presence of irregular, painless, periarticular soft tissue calcifying masses, and pathologically by fibrous-walled cystic spaces containing structureless calcific debris and associated with a variable inflammatory reaction...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:

    authors: Harwood CA,Cook MG,Mortimer PS

    更新日期:1996-03-01 00:00:00

  • A review of high-dose intravenous immunoglobulin (hdIVIg) in the treatment of the autoimmune blistering disorders.

    abstract::High-dose intravenous immunoglobulin (hdIVIg) is being used increasingly for dermatological indications. Its mode of action is via a number of proposed mechanisms and it is not associated with the many side-effects of steroids and other immunosuppressive agents. The evidence for using hdIVIg in the treatment of autoim...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2230.2001.00779.x

    authors: Jolles S

    更新日期:2001-03-01 00:00:00

  • Nodular cystic fat necrosis in a patient with erythema nodosum.

    abstract::Nodular cystic fat necrosis shows a distinctive spectrum of clinical and histological features. Most of the lesions are mobile subcutaneous nodules in regions vulnerable to trauma, such as the elbows, knees, and shins. There have been no reports of an association with other conditions. The histology is characterized b...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1995.tb01319.x

    authors: Ahn SK,Lee BJ,Lee SH,Lee WS

    更新日期:1995-05-01 00:00:00

  • Scar sarcoidosis in childhood: case report and review of the literature.

    abstract::Sarcoidosis is a rare disease among children, manifesting differently in children below and above 4-5 years of age. Although the exact incidence and prevalence of childhood sarcoidosis is not known, the cutaneous involvement is frequent in both children and adults. Infiltration of old cutaneous scars with sarcoid gran...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2230.2005.01727.x

    authors: Singal A,Thami GP,Goraya JS

    更新日期:2005-05-01 00:00:00

  • Comparison of two dye lasers in the treatment of port-wine stains.

    abstract:BACKGROUND:Port-wine stains (PWS) are congenital capillary malformations that persist throughout life. Laser therapy is a common treatment for PWS, and pulsed-dye laser is the current treatment of choice. AIM:To compare the clinical results on untreated PWS of two dye lasers with different wavelengths and pulse durati...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2009.03399.x

    authors: Frohm Nilsson M,Passian S,Wiegleb Edstrom D

    更新日期:2010-03-01 00:00:00

  • Time to progression from discoid lupus erythematosus to systemic lupus erythematosus: a retrospective cohort study.

    abstract::Determining the risk of progression to systemic lupus erythematosus (SLE) among patients diagnosed with discoid lupus erythematosus (DLE), and the time frame of this risk, are important clinical questions. Past reports have demonstrated a wide time frame of progression from DLE to SLE, with mean time to progression of...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.14014

    authors: Elman SA,Joyce C,Costenbader KH,Merola JF

    更新日期:2020-01-01 00:00:00

  • Severe acute generalized exanthematous pustulosis with blistering mimicking toxic epidermal necrolysis, associated with a primary mumps infection.

    abstract::Acute generalized exanthematous pustulosis (AGEP) is a severe adverse cutaneous reaction, which is mostly due to drugs, but which has also been described as occurring after infections. We report a case of severe AGEP with extensive blistering mimicking toxic epidermal necrolysis (TEN) in a 47-year-old woman. This was ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12384

    authors: Azib S,Florin V,Fourrier F,Delaporte E,Staumont-Sallé D

    更新日期:2014-08-01 00:00:00

  • Association of the interleukin-10 distal promoter (-2763A/C) polymorphism with late-onset psoriasis.

    abstract::Polymorphisms of the IL-10 promoter have been implicated in the genetic susceptibility to many autoimmune diseases, including psoriasis. Four putative functional single-nucleotide polymorphisms (SNPs) within the interleukin-10 promoter region (-3575T/A, -2763A/C, -1082G/A and -592C/A) were analysed in 139 patients wit...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2007.02628.x

    authors: Wongpiyabovorn J,Hirankarn N,Ruchusatsawat K,Yooyongsatit S,Asawanonda P,Poovorawan Y

    更新日期:2008-03-01 00:00:00

  • Acral histiocytic nodules: a possible new variant of non-X histiocytosis.

    abstract::Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the backgr...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2011.04207.x

    authors: Patel AN,Cohen SN,Leach IH,Scharrer K

    更新日期:2012-04-01 00:00:00

  • The A/A genotype of an interleukin-17A polymorphism predisposes to increased severity of atopic dermatitis and coexistence with asthma.

    abstract:INTRODUCTION:Studies have found that the interleukin-23/T helper 17 (IL-23/Th17) pathway plays an important role in the pathogenesis of atopic dermatitis (AD). Inhibition of the IL-23/Th17 pathway with monoclonal antibodies reduces skin inflammation in animal models. AIM:To investigate the association between IL-17A a...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/ced.12438

    authors: Narbutt J,Wojtczak M,Zalińska A,Salinski A,Przybylowska-Sygut K,Kuna P,Majak P,Sysa-Jedrzejowska A,Lesiak A

    更新日期:2015-01-01 00:00:00

  • Cutaneous melanoma: a population-based epidemiology report with 989 patients in Hong Kong.

    abstract::Studies in white populations have confirmed advanced age as a risk factor for cutaneous melanoma, but in nonwhite populations, its role is less clear. To clarify a possible association in our local population, comprising 94.9% Chinese, a retrospective epidemiological study of 20 years of data on cutaneous melanoma bet...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.2007.02377.x

    authors: Hui SK,Tang WY,Wong TW,Lau KH,Lee S,Chong LY,Lo KK

    更新日期:2007-05-01 00:00:00

  • Localized multiple neurofibromas.

    abstract::Two cases of localized multiple neurofibromas are reported. The patients had fairly large, closely grouped neurofibromas limited to a circumscribed part of the body, a very different clinical feature from segmental neurofibromatosis, but with otherwise had typical histopathological features. Possible aetiology is disc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1992.tb00205.x

    authors: Mohri S,Atsusaka K,Sasaki T

    更新日期:1992-05-01 00:00:00

  • Therapeutic efficacy and safety of oral tranexamic acid and that of tranexamic acid local infiltration with microinjections in patients with melasma: a comparative study.

    abstract:BACKGROUND:Tranexamic acid (TXA) has been used orally, intravenously, topically and intradermally (microinjection, microneedling) for treating melasma. However, the comparative efficacy of these different routes of administration remains underevaluated. AIM:To ascertain the comparative efficacy of different routes of ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ced.13164

    authors: Sharma R,Mahajan VK,Mehta KS,Chauhan PS,Rawat R,Shiny TN

    更新日期:2017-10-01 00:00:00

  • Leg ulcers in hereditary spherocytosis.

    abstract::Refractory leg ulcers in two patients healed following splenectomy. Neither patient had the ethnic background or family history of haematological abnormalities to suggest a haemoglobinopathy. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2230.1991.tb00289.x

    authors: Lawrence P,Aronson I,Saxe N,Jacobs P

    更新日期:1991-01-01 00:00:00