HLA-DR and DQ polymorphisms in bullous pemphigoid from northern China.

Abstract:

:Bullous pemphigoid (BP) is an autoimmune disease mediated by autoantibodies against hemidesmosome components. This study used PCR-sequence-specific primers to genotype polymorphisms in HLA-DR and DQ in 25 BP patients and 57 normal controls from northern China. We found lower frequencies of DRB1*08 (DR8) and DRB1*08/DQB1*06 (DR8/DQ6) haplotypes in BP patients than in controls (4.08% vs. 15.19% and 1.54% vs. 13.82%, respectively; P < 0.05), suggesting a protective role for DR8 and DR8/DQ6 haplotypes in BP patients from northern China; there were no statistical differences among other alleles tested. This result is strikingly different from previous reports that DQB1*0301 is associated with BP in Caucasian patients and DRB1*1101, DQB1*0302, DRB1*04/DQA1*0301/DQB1*0302 and DRB1*1101/ DQA1*0505/DQB1*0302 with Japanese BP patients. Ethnic differences in the polymorphic composition of the HLA-DR and DQ genes may influence genetic susceptibility to BP.

journal_name

Clin Exp Dermatol

authors

Gao XH,Winsey S,Li G,Barnardo M,Zhu XJ,Chen HD,Song F,Zhai N,Fuggle S,Wojnarowska F

doi

10.1046/j.1365-2230.2002.01037.x

keywords:

subject

Has Abstract

pub_date

2002-06-01 00:00:00

pages

319-21

issue

4

eissn

0307-6938

issn

1365-2230

pii

1037

journal_volume

27

pub_type

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