Abstract:
:A 68-year-old Caucasian male presented with a 5-week history of a widespread pruritic papular eruption. Histology from a papule on the left shoulder showed a dense dermal infiltrate of large mononuclear cells which were positive for leucocyte common antigen, KP1 and PGM1, with an MIB-1 proliferating fraction of 40%, diagnostic of acute monocytic (M5) leukaemia cutis. Full blood count revealed pancytopaenia but no blasts. Bone marrow aspirate showed reduced red cell precursors and 10% blasts, consistent with myelodysplastic syndrome (refractory anaemia with excess blasts). The patient was managed with a 3 unit transfusion of packed red cells, after which his skin eruption resolved within 6 weeks and his peripheral blood counts returned to normal. No chemotherapy was administered. In conclusion, leukaemia can present in the skin, the eruption may be nonspecific and it may precede systemic involvement by either myelodysplastic syndrome or acute leukaemia.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Millard TP,Aitchison R,Wilkinson JDdoi
10.1046/j.1365-2230.2003.01172.xkeywords:
subject
Has Abstractpub_date
2003-03-01 00:00:00pages
148-50issue
2eissn
0307-6938issn
1365-2230pii
1172journal_volume
28pub_type
杂志文章abstract::The Langerhans cells in the lentigines of four patients with the Leopard syndrome contained large membrane bound accumulations of melanin granules. Giant melanosomes were only seen in two patients. The patients had no immune-based symptoms relating to their lentigines. The Leopard Syndrome, also known as multiple lent...
journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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journal_title:Clinical and experimental dermatology
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更新日期:1997-09-01 00:00:00
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journal_title:Clinical and experimental dermatology
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doi:
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