Sebaceous gland hyperplasia of the foreskin.

Abstract:

:Two men, aged in their 20s, presented with multiple, soft, rounded papules on the prepuce. The lesions were centrally umbilicated, resembling molluscum contagiosum, but clearly distinct from Tyson's glands. Surface microscopy showed well-defined, milky-white, bag-shaped structures, which under histological examination were found to be sebaceous glands with various features of hyperplasia. A lymphocytic T-cell infiltrate, closely associated with progressive degeneration and destruction of the sebocytes, was visible around the glands. In the differential diagnosis of penile papular lesions, this unusual clinical presentation supported by dermatoscopy is consistent with preputial sebaceous gland hyperplasia. As both patients had a prominent T-cell infiltration, it is possible that under inflammatory stimulation, sebaceous glands undergo hypertrophy and gradual central involution.

journal_name

Clin Exp Dermatol

authors

Ena P,Origa D,Massarelli G

doi

10.1111/j.1365-2230.2008.02998.x

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

372-4

issue

3

eissn

0307-6938

issn

1365-2230

pii

CED2998

journal_volume

34

pub_type

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