Role of autologous mesenchymal stem cells associated with platelet-rich plasma on healing of cutaneous wounds in diabetic mice.

Abstract:

BACKGROUND:Chronic cutaneous lesions affect 15% of human patients with diabetes, and the associated risk of limb amputations is 15-46 times greater than that of people with normal glycaemia. It is estimated that half of these limb amputations could be avoided by opportune treatment with somatic stem cells or platelet-rich plasma (PRP). METHODS:We evaluated the effects of autologous transplant of mesenchymal stem cells (MSCs) with or without combination with autologous PRP in the re-epithelialization of cutaneous lesions induced in diabetic mice. RESULTS:Animals treated with MSCs alone showed a similar level of re-epithelialization of cutaneous lesions to those treated with MSC plus PRP, and no significant difference was found between the two treatments. CONCLUSION:Both treatments gave better results than daily cleaning of the cutaneous lesions with saline or covering of the lesions with semipermeable adherent bandage.

journal_name

Clin Exp Dermatol

authors

Argôlo Neto NM,Del Carlo RJ,Monteiro BS,Nardi NB,Chagastelles PC,de Brito AF,Reis AM

doi

10.1111/j.1365-2230.2011.04304.x

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

544-53

issue

5

eissn

0307-6938

issn

1365-2230

journal_volume

37

pub_type

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