Abstract:
BACKGROUND:Chronic cutaneous lesions affect 15% of human patients with diabetes, and the associated risk of limb amputations is 15-46 times greater than that of people with normal glycaemia. It is estimated that half of these limb amputations could be avoided by opportune treatment with somatic stem cells or platelet-rich plasma (PRP). METHODS:We evaluated the effects of autologous transplant of mesenchymal stem cells (MSCs) with or without combination with autologous PRP in the re-epithelialization of cutaneous lesions induced in diabetic mice. RESULTS:Animals treated with MSCs alone showed a similar level of re-epithelialization of cutaneous lesions to those treated with MSC plus PRP, and no significant difference was found between the two treatments. CONCLUSION:Both treatments gave better results than daily cleaning of the cutaneous lesions with saline or covering of the lesions with semipermeable adherent bandage.
journal_name
Clin Exp Dermatoljournal_title
Clinical and experimental dermatologyauthors
Argôlo Neto NM,Del Carlo RJ,Monteiro BS,Nardi NB,Chagastelles PC,de Brito AF,Reis AMdoi
10.1111/j.1365-2230.2011.04304.xsubject
Has Abstractpub_date
2012-07-01 00:00:00pages
544-53issue
5eissn
0307-6938issn
1365-2230journal_volume
37pub_type
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