Generalized melanosis with malignant melanoma metastasizing to skin--a pathological study with S-100 protein and HMB-45.

abstract：BACKGROUND:In drug-induced toxic epidermal necrolysis (TEN), the epidermal destruction is associated with a slight to moderate lymphomonocytic cell infiltrate. Interleukin (IL)-8, which is a keratinocyte-derived pro-inflammatory cytokine, might be involved in this process. The IL-8 receptor CXCR2 has also been shown to...

journal_title：Clinical and experimental dermatology

authors： Paquet P,Ribbens C,Piérard GE

更新日期：2007-11-01 00:00:00

abstract：:Cryosurgery is an alternative treatment option to surgical excision for lentigo maligna. Clinical evidence of recurrence is usually characterized by repigmentation at the treated site. We report two patients who developed amelanotic malignant melanoma following cryosurgery for a pigmented lentigo maligna. These cases ...

journal_title：Clinical and experimental dermatology

authors： McKenna DB,Cooper EJ,Kavanagh GM,Davie RM,McLaren KM,Tidman MJ

更新日期：2000-11-01 00:00:00

abstract：:Steatocystoma multiplex is a rare, autosomal dominant condition characterized by multiple cysts, usually arising on the trunk and proximal extremities at puberty. We present two unrelated women with sporadic steatocystoma multiplex strictly confined to the vulva and arising at an older age. These cases represent an un...

journal_title：Clinical and experimental dermatology

authors： Rongioletti F,Cattarini G,Romanelli P

更新日期：2002-09-01 00:00:00

abstract：:The clinical characteristics associated with hidradenitis suppurativa (HS) severity are poorly understood. In this study, 124 patients with HS from 6 Italian dermatology centres participated in this study. Disease severity was assessed using the Hidradenitis Suppurativa Physician's Global Assessment score (HS-PGA) and...

journal_title：Clinical and experimental dermatology

authors： Bianchi L,Caposiena Caro RD,Ganzetti G,Molinelli E,Dini V,Oranges T,Romanelli M,Fabbrocini G,Monfrecola G,Napolitano M,Egan CG,Musumeci ML,Lacarrubba F,Micali G,Passoni E,Calzavara-Pinton PG,Venturini M,Zanca A,Offida

更新日期：2019-07-01 00:00:00

abstract：:A case of Bowen's disease is described in which striking quantities of amyloid were detected in the papillary dermis visualized easily by routine haematoxylin and eosin staining. The material showed positive labelling with an antikeratin monoclonal antibody consistent with the proposed origin of the amyloid as degener...

journal_title：Clinical and experimental dermatology

authors： Speight EL,Milne DS,Lawrence CM

更新日期：1993-05-01 00:00:00

abstract：:We report a 72-year-old man on haemodialysis who presented with multiple abscesses on his lower legs. Routine bacterial culture of abscess pus was reported as 'sterile' after 48 h, leading to the suspicion of a mycobacterial infection. Skin biopsy taken for mycobacterial microscopy and culture isolated a heavy growth ...

journal_title：Clinical and experimental dermatology

authors： Morris-Jones R,Fletcher C,Morris-Jones S,Brown T,Hilton RM,Hay R

更新日期：2001-07-01 00:00:00

abstract：:Rapp-Hodgkin syndrome (RHS) is an autosomal dominant disorder characterized by ectodermal dysplasia and cleft lip/cleft palate. Very recently, mutations in p63 have been identified as a cause of RHS; to date five such mutations have been identified. We describe a Thai girl with RHS. She had short stature, ectodermal d...

journal_title：Clinical and experimental dermatology

authors： Shotelersuk V,Janklat S,Siriwan P,Tongkobpetch S

更新日期：2005-05-01 00:00:00

abstract：:The Renbök phenomenon (or Inverse Köbner phenomenon) describes how the emergence of one skin condition inhibits another skin condition. The term was first coined in 1991 by Happle et al. to describe retained hair growth localised to psoriatic plaques in a patient with coexisting psoriasis and alopecia areata (AA). Sub...

journal_title：Clinical and experimental dermatology

authors： Nemazee L,Harries M

更新日期：2020-11-05 00:00:00

abstract：BACKGROUND:Previous studies have shown that concomitant administration of food may enhance the bioavailability of oral retinoids. AIM:To assess the influence of food on the pharmacokinetics (PK) of alitretinoin after a single oral dose. METHODS:This was a single-dose, open-label, randomized, crossover study, which en...

journal_title：Clinical and experimental dermatology

authors： Schmitt-Hoffmann AH,Roos B,Sauer J,Schleimer M,Kovācs P,Stoeckel K,Maares J

更新日期：2011-04-01 00:00:00

abstract：:Pruritus measurement is problematic, because of its subjective nature and poor localization. Ratio scales enhance the usefulness of the visual analogue scale (VAS) by reducing variation; other scales such as the generalized labelled magnitude scale may also be useful. Pruritus neuroanatomy includes peripheral receptor...

journal_title：Clinical and experimental dermatology

authors： Langner MD,Maibach HI

更新日期：2009-04-01 00:00:00

abstract：:Vitiligo usually begins in childhood with approximately half of the patients manifesting onset of disease prior to the age of 20 years. Treatment options in this age group are few and have disappointing response rates. This study was designed to evaluate the role of narrow-band UVB in the treatment of generalized viti...

journal_title：Clinical and experimental dermatology

authors： Kanwar AJ,Dogra S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Recently, increased evidence has shown that serum micro (mi)RNA levels are a useful biomarker for the diagnosis, prognosis and therapeutic value of various diseases. However, serum miRNA has not been investigated in patients with systemic sclerosis (SSc), to our knowledge. AIM:To investigate the possibility...

journal_title：Clinical and experimental dermatology

authors： Makino K,Jinnin M,Kajihara I,Honda N,Sakai K,Masuguchi S,Fukushima S,Inoue Y,Ihn H

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The main cause of lichen simplex chronicus (LSC) is not known but there is evidence to suggest that neurological abnormalities may be implicated in its aetiology. AIM:To investigate neuropathy in patients with LSC on the limbs. METHODS:In total, 23 consecutive patients [15 women (65.2%) and 8 men (34.8%); ...

journal_title：Clinical and experimental dermatology

authors： Solak O,Kulac M,Yaman M,Karaca S,Toktas H,Kirpiko O,Kavuncu V

更新日期：2009-06-01 00:00:00

abstract：:Photo-damage of the head and neck was assessed, by visual inspection, in 82 Northern European renal transplant recipients attending a dermatology clinic. Photo-damage was graded as absent, mild, moderate and severe and the presence or absence of skin telangiectasia, solar elastosis, erythema and pigmentation was asses...

journal_title：Clinical and experimental dermatology

authors： Cooper SM,Wojnarowska F

更新日期：2003-11-01 00:00:00

abstract：:Severe cases of psoriasis and psoriasis arthritis require systemic treatment. Although a number of established drugs are in clinical use, there is a need for new compounds with an improved risk-benefit ratio with a major emphasis on long-term safety. Furthermore, patients with moderate psoriasis ask for systemic drugs...

journal_title：Clinical and experimental dermatology

authors： Mrowietz U

更新日期：2001-06-01 00:00:00

abstract：:We report a patient of Malay ancestry with dermatopathia pigmentosa reticularis (DPR) resulting from a recurrent KRT14 p.R125C mutation. The patient has reticulate hyperpigmentation over his trunk and proximal limbs, together with onychodystrophy. Despite the absence of noncicatricial alopecia, he has acral nonscarrin...

journal_title：Clinical and experimental dermatology

authors： Goh BK,Common JE,Gan WH,Kumarasinghe P

更新日期：2009-04-01 00:00:00

abstract：:Dermanyssus gallinae is a mite that normally parasitizes small birds but may occasionally bite humans. We report an unusual case of an 82-year-old woman who presented with pruritus and bite-like lesions over her trunk. Other members of the household were also affected. On physical examination, mites < 1 mm in size wer...

journal_title：Clinical and experimental dermatology

authors： Collgros H,Iglesias-Sancho M,Aldunce MJ,Expósito-Serrano V,Fischer C,Lamas N,Umbert-Millet P

更新日期：2013-06-01 00:00:00

abstract：:We present a case of paraneoplastic pemphigus associated with Castleman's disease. Our patient had stomatitis and vulvar erosions followed by a cutaneous polymorphous eruption. Investigations for neoplasia disclosed a Castleman's tumour suggesting the diagnosis of paraneoplastic pemphigus. The diagnosis was supported ...

journal_title：Clinical and experimental dermatology

authors： Caneppele S,Picart N,Bayle-Lebey P,Paul J,Irsutti M,Oksman F,Joly P,Bazex J

更新日期：2000-05-01 00:00:00

abstract：:Fourteen patients with psoriasis received long-term treatment with cyclosporin (CsA). Among patients there was great variability in the minimal effective CsA dose. In most patients long-term treatment was limited due to dose reductions made necessary because of side-effects. The therapeutic window for CsA seems small....

journal_title：Clinical and experimental dermatology

authors： Korstanje MJ,Van de Staak WJ

更新日期：1991-01-01 00:00:00

abstract：:Common unifying features of the subepidermal blistering diseases are the presence of tense blisters clinically and demonstration by immunofluorescence of linear deposition of immunoreactants along the dermoepidermal junction. Further characterization of subtype is possible by identification of the target antigen by im...

journal_title：Clinical and experimental dermatology

authors： Rao R,Bhogal B,Groves R

更新日期：2013-04-01 00:00:00

abstract：:Pachydermodactyly describes a rare condition of localized fibromatosis, usually symmetrically affecting the interphalangeal joints of both hands. We describe a case of a new subtype of pachydermodactyly in a 14-year-old boy, which we term 'unilateral pachydermodactyly transgrediens'. This atypical pattern is caused by...

journal_title：Clinical and experimental dermatology

authors： Nicolay JP,Faulhaber J,Kutzner H,Schneider SW

更新日期：2015-08-01 00:00:00

abstract：:Refractory leg ulcers in two patients healed following splenectomy. Neither patient had the ethnic background or family history of haematological abnormalities to suggest a haemoglobinopathy. ...

journal_title：Clinical and experimental dermatology

authors： Lawrence P,Aronson I,Saxe N,Jacobs P

更新日期：1991-01-01 00:00:00

abstract：:Human papillomavirus (HPV) is the most common sexually transmitted disorder in young, sexually active populations in the USA and Europe. Giant condyloma acuminatum (GCA) is a unique variant of condyloma acuminata, characterized by local aggressive behaviour despite benign histology. It carries a substantial risk of sq...

journal_title：Clinical and experimental dermatology

authors： Erkek E,Basar H,Bozdogan O,Emeksiz MC

更新日期：2009-04-01 00:00:00

abstract：:Erosive pustular dermatosis (EPD) of the leg is an unusual form of amicrobial pustulosis, which typically affects elderly patients with chronic venous insufficiency. We report a patient who presented with painful erythema, crusted erosions and pustules on her right lower leg. Histology showed a dermal infiltration mad...

journal_title：Clinical and experimental dermatology

authors： Zhou Z,Zhang ZK,Liu TH

更新日期：2015-12-01 00:00:00

abstract：:A 69-year-old woman presented with a nonhealing ulcer on her right cheek. On histological examination of a biopsy, no evidence of granuloma formation or malignancy was found, and the overall picture was felt to be consistent with dermatitis artefacta (DA). The patient was referred to a joint psychodermatology clinic, ...

journal_title：Clinical and experimental dermatology

authors： Lowry CL,Bewley A,Taylor R

更新日期：2013-07-01 00:00:00

abstract：:Dapsone has potent anti-inflammatory effects, and is used in the treatment of leprosy, cutaneous vasculitis, neutrophilic dermatoses, and dermatitis herpetiformis and other blistering disorders. However, it may cause severe adverse reactions such as hypersensitivity syndrome, which is characterized by fever, skin rash...

journal_title：Clinical and experimental dermatology

authors： Chun JS,Yun SJ,Kim SJ,Lee SC,Won YH,Lee JB

更新日期：2009-12-01 00:00:00

abstract：:Hydroxyurea is an anti-tumour agent most commonly used to treat chronic myeloproliferative disorders in doses up to 4 g per day. Dermatological adverse effects reported so far have been observed predominantly in these patients. As we are treating selected psoriasis patients with low dose hydroxyurea we attempted to de...

journal_title：Clinical and experimental dermatology

authors： Kumar B,Saraswat A,Kaur I

更新日期：2002-01-01 00:00:00

abstract：:An earlier standard syphilology textbook states that 'If vesicles are an essential part of an eruption in an adult, the lesions are not due to secondary syphilis'. However, vesicular and bullous eruptions do occur in congenital syphilis and rare reports of both vesicular and pustular eruptions in adults with secondary...

journal_title：Clinical and experimental dermatology

authors： Lawrence P,Saxe N

更新日期：1992-01-01 00:00:00

abstract：:Drug reactions are common in HIV-1 disease, with the incidence having been reported to increase with increasing stage and with CD4+ T-cell counts below 200/microliters. However, there have been numerous reports of patients in which rechallenge, dosing changes or continued therapy have resulted in no recurrence or else...

journal_title：Clinical and experimental dermatology

authors： Smith KJ,Skelton HG,Yeager J,Ledsky R,Ng TH,Wagner KF

更新日期：1997-05-01 00:00:00

abstract：BACKGROUND:Lichen planopilaris (LPP) is characterized by lymphocytic infiltrate, fibrosis and potential destruction of the hair follicle. Demographic and clinical studies in LPP are limited, and racial differences have not been thoroughly investigated. AIM:To analyse epidemiological data and clinical profiles of Chile...

journal_title：Clinical and experimental dermatology

authors： Mardones F,Shapiro J

更新日期：2017-10-01 00:00:00