Quality of life, emotion dysregulation, attention deficit and psychiatric comorbidity in children and adolescents with vitiligo.


BACKGROUND:Vitiligo is an acquired pigmentation disorder, which can have a negative effect on patient quality of life (QoL). AIM:To evaluate QoL and psychiatric comorbidity in paediatric patients with vitiligo. METHODS:In total, 30 patients aged 8-18 years who were diagnosed with vitiligo and 30 age- and sex-matched healthy controls (HCs) were included in the study. The Children's Depression Inventory, Screen for Child Anxiety Related Disorders, State-Trait Anxiety Inventory for Children and Child Somatization Inventory were completed for both patients and controls. The Schedule for Affective Disorders and Schizophrenia for School Age Children-Present and Lifetime Version (K-SADS-PL) was administered to all patients by a child psychiatrist. Families were also asked to complete the Pediatric Quality of Life Inventory and Emotion Regulation Checklist for children. RESULTS:The K-SADS-PL evaluation showed that 90% of the patients in the vitiligo group had at least one psychiatric diagnosis, whereas this rate was 20% in the HCs (P < 0.001). There were statistically significant differences between vitiligo and HCs in terms of anxiety, state and trait anxiety scores (P < 0.05). Attention deficit and hyperactivity disorder (ADHD) was detected in 36.6% of the patients. CONCLUSION:The most important finding of this study is that anxiety disorders are more prominent than depression in childhood vitiligo. Another important finding of this study is that the prevalence of ADHD is significantly higher than the normal population.


Clin Exp Dermatol


Ucuz I,Altunisik N,Sener S,Turkmen D,Kavuran NA,Marsak M,Colak C




Has Abstract


2020-02-16 00:00:00






  • Paediatric vulval lichen sclerosus: a retrospective study.

    abstract:BACKGROUND:Lichen sclerosus (LS) is a chronic inflammatory dermatosis with a predilection for the anogenital region, which mainly affects prepubertal girls and postmenopausal women. The cause is unknown, but a number of potential aetiological factors have been identified. AIM:To examine a cohort of patients with prepu...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ismail D,Owen CM

    更新日期:2019-10-01 00:00:00

  • Sebaceous gland hyperplasia of the foreskin.

    abstract::Two men, aged in their 20s, presented with multiple, soft, rounded papules on the prepuce. The lesions were centrally umbilicated, resembling molluscum contagiosum, but clearly distinct from Tyson's glands. Surface microscopy showed well-defined, milky-white, bag-shaped structures, which under histological examination...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ena P,Origa D,Massarelli G

    更新日期:2009-04-01 00:00:00

  • Psoriasis or crusted scabies.

    abstract::We describe a case of a 67-year-old woman with a 1-year history of nail thickening and a non-itchy erythematous scaly eruption on the fingertips. She was diagnosed with psoriasis and started on methotrexate after having had no response to topical calcipotriol. The diagnosis was reviewed after it was revealed by anothe...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Goyal NN,Wong GA

    更新日期:2008-03-01 00:00:00

  • Does EMLA reduce the discomfort associated with local-anaesthetic infiltration?

    abstract::The effectiveness of EMLA cream in relieving the discomfort associated with percutaneous infiltration of lignocaine was assessed in a double-blind, placebo-controlled study. Patients undergoing minor skin surgery were divided into two groups, according to the number of lesions requiring surgery. The first group had a ...

    journal_title:Clinical and experimental dermatology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Jones SK,Handfield-Jones S,Kennedy CT

    更新日期:1990-05-01 00:00:00

  • Depigmentation therapy in vitiligo universalis with cryotherapy and 4-hydroxyanisole.

    abstract::Vitiligo is a disease characterized by the loss of melanocytes, resulting in progressive depigmentation of skin, and areas of normally pigmented skin can be of cosmetic concern. Several options have been tried to remove the pigment and make the skin a more even colour. We present an easy and effective therapeutic proc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Di Nuzzo S,Masotti A

    更新日期:2010-03-01 00:00:00

  • UVA1 phototherapy for treatment of necrobiosis lipoidica.

    abstract::The primary cause of collagen degeneration in necrobiosis lipoidica (NL) is proposed to be immunologically mediated vascular disease. Ultraviolet (UV)A1 has been used successfully to treat scleroderma in which both vascular damage and collagen dysregulation also occur. We treated six patients with NL [(five women; mea...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Beattie PE,Dawe RS,Ibbotson SH,Ferguson J

    更新日期:2006-03-01 00:00:00

  • Calcineurin inhibitors and sirolimus: mechanisms of action and applications in dermatology.

    abstract::Controlled trials and clinical experience indicate that systemic cyclosporin A and tacrolimus are effective treatments for psoriasis, and that cyclosporin A also improves atopic eczema. A variety of other inflammatory and non-inflammatory skin diseases are probably also responsive to these drugs. However, the widespre...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Reynolds NJ,Al-Daraji WI

    更新日期:2002-10-01 00:00:00

  • Intercellular IgA dermatosis (IgA pemphigus)--two cases illustrating the clinical heterogeneity of this disorder.

    abstract::IgA pemphigus is rare but may be underdiagnosed. We describe two cases, a 50-year-old female with a pustular eruption resembling subcorneal pustular dermatosis and a 55-year-old male with a pruritic vesiculopustular eruption simulating dermatitis herpetiformis. They illustrate the clinical heterogeneity of IgA pemphig...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Harman KE,Holmes G,Bhogal BS,McFadden J,Black MM

    更新日期:1999-11-01 00:00:00

  • Proopiomelanocortin (POMC): the cutaneous roles of its melanocortin products and receptors.

    abstract::The precursor protein proopiomelanocortin (POMC) produces many biologically active peptides via a series of enzymatic steps in a tissue-specific manner, yielding the melanocyte-stimulating hormones (MSHs), corticotrophin (ACTH) and beta-endorphin. The gene for alpha-MSH is encoded for by the POMC gene, but alpha-MSH c...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Millington GW

    更新日期:2006-05-01 00:00:00

  • Management of nail psoriasis.

    abstract::Nail involvement is estimated to affect 80-90% of patients with psoriasis at some point in their lives and is often associated with severe disease. Patients with nail involvement experience pain, functional impairment and social stigma, with significant restriction of daily activities and quality of life. Nail psorias...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Thomas L,Azad J,Takwale A

    更新日期:2021-01-01 00:00:00

  • Graham Little-Piccardi-Lassueur syndrome: effective treatment with cyclosporin A.

    abstract::Graham Little-Piccardi-Lassueur syndrome (GLPLS) is a rare lichenoid dermatosis defined by scarring alopecia, loss of pubic and axillary hairs and progressive development of horny follicular papules variously located. Topical or systemic corticosteroids, retinoids or PUVA therapy are the treatments usually proposed an...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Bianchi L,Paro Vidolin A,Piemonte P,Carboni I,Chimenti S

    更新日期:2001-09-01 00:00:00

  • Aspergillus fumigatus Majocchi's granuloma in a patient with acquired immunodeficiency syndrome.

    abstract::Majocchi's granuloma, also known as nodular granulomatous perifolliculitis, is an uncommon fungal infection of the skin and subcutaneous tissue. It can occur in healthy and immunocompromised patients. The most common cause of Majocchi's granuloma is Trichophyton rubrum. We report a case of a Majocchi's granuloma cause...

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    pub_type: 杂志文章


    authors: Saadat P,Kappel S,Young S,Abrishami M,Vadmal MS

    更新日期:2008-07-01 00:00:00

  • Nutritional factors and hair loss.

    abstract::The literature reveals what little is known about nutritional factors and hair loss. What we do know emanates from studies in protein-energy malnutrition, starvation, and eating disorders. In otherwise healthy individuals, nutritional factors appear to play a role in subjects with persistent increased hair shedding. H...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Rushton DH

    更新日期:2002-07-01 00:00:00

  • Precalcaneal congenital fibrolipomatous hamartoma.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Flann S,Munn SE

    更新日期:2009-06-01 00:00:00

  • Loceryl nail lacquer--realization of a new galenical approach to onychomycosis therapy.

    abstract::Loceryl nail lacquer was developed to provide the effective antifungal drug, amorolfine, in a once-weekly dosage regimen combined with a convenient mode of application. Traditional formulations such as creams and nail solutions do not fulfil these requirements because they are wiped or washed off very rapidly. Amorolf...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Pittrof F,Gerhards J,Erni W,Klecak G

    更新日期:1992-09-01 00:00:00

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Sheth N,Sarker SJ,Harries M,Healy C,Russell-Jones R,Acland K

    更新日期:2010-08-01 00:00:00

  • Urticaria associated with thyrotoxicosis.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Henderson CA,Highet AS

    更新日期:1995-03-01 00:00:00

  • Ceramide profile in hypohidrotic ectodermal dysplasia.

    abstract:BACKGROUND:Hypohidrotic ectodermal dysplasia (HED) is a rare genetic disease. The clinical presentation includes lack of sweating ability, and an often widely spread dermatitis resembling atopic dermatitis (AD). In AD, the skin-barrier defect is partly ascribed to the altered lipid profile in the stratum corneum and pa...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Jungersted JM,Høgh JK,Hellgren LI,Agner T,Jemec GB

    更新日期:2012-03-01 00:00:00

  • Pemphigus vulgaris following varicella infection.

    abstract::We describe a 26-year-old Indian man who presented with chickenpox and subsequently developed pemphigus vulgaris 17 days after initial resolution of lesions. The mechanism of progression from one disease to the other is postulated to be that of epitope spreading or molecular mimicry. ...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Goon AT,Tay YK,Tan SH

    更新日期:2001-11-01 00:00:00

  • Use of a novel autologous cell-harvesting device to promote epithelialization and enhance appropriate pigmentation in scar reconstruction.

    abstract:BACKGROUND:Epidermal replacement is an important step in the management of patients with post-traumatic and iatrogenic scars. Skin-colour variation from disease or trauma causes significant changes in self-image and appearance. AIM:The aim of our study was to analyse the results obtained with a novel autologous cell-h...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Cervelli V,De Angelis B,Spallone D,Lucarini L,Arpino A,Balzani A

    更新日期:2010-10-01 00:00:00

  • Acute severe bronchoconstriction precipitated by coal tar bandages.

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    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Ibbotson SH,Stenton SC,Simpson NB

    更新日期:1995-01-01 00:00:00

  • Partial atrophic tongue other than median rhomboid glossitis.

    abstract::A group of 23 patients with partial atrophic change of the tongue was examined for candidiasis. All of them reported pain in the tongue on eating hot or spicy food. The intensity of the tongue pain was evaluated before and after treatment using a visual analogue scale. Of the 23 patients, 10 (43.5%) had predisposing f...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Terai H,Shimahara M

    更新日期:2007-07-01 00:00:00

  • Immunobullous dermatosis associated with Waldenström macroglobulinaemia treated with rituximab.

    abstract::Waldenström macroglobulinaemia (WM) is a chronic lymphoproliferative disorder characterized by the presence of a monoclonal IgM paraprotein. Specific cutaneous features of WM include neoplastic cell infiltrates, IgM storage papules and IgM bullous dermatosis. We report a patient with subepidermal bullous disease assoc...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Chattopadhyay M,Rytina E,Dada M,Bhogal BS,Groves R,Handfield-Jones S

    更新日期:2013-12-01 00:00:00

  • 'I saw it on Facebook!' Assessing the influence of social media on patient presentation to a melanoma screening clinic.

    abstract:BACKGROUND:The motivations for patients presenting to melanoma screening clinics (MSCs) with concerning skin lesions are poorly understood. Social media (SoMe) refers to online platforms designed to facilitate sharing of information with billions of users worldwide. There is evidence of patients posting skin lesion 'se...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Guckian J,Jobling K,Oliphant T,Weatherhead S,Blasdale K

    更新日期:2020-04-01 00:00:00

  • Late onset vulvar steatocystoma multiplex.

    abstract::Steatocystoma multiplex is a rare, autosomal dominant condition characterized by multiple cysts, usually arising on the trunk and proximal extremities at puberty. We present two unrelated women with sporadic steatocystoma multiplex strictly confined to the vulva and arising at an older age. These cases represent an un...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Rongioletti F,Cattarini G,Romanelli P

    更新日期:2002-09-01 00:00:00

  • Serum triamcinolone levels during intensive, inpatient wet-dressing therapy.

    abstract:BACKGROUND:Wet dressings combined with topical corticosteroids are beneficial for patients with generalized and refractory dermatosis; however, to our knowledge, serum levels after topical corticosteroid absorption during intensive therapy have not been reported previously. AIM:To examine serum levels of triamcinolone...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Mirza SA,Wentworth AB,Harvey JA,Bridges AG,Camilleri MJ,El-Azhary RA,McEvoy MT,Sartori Valinotti JC,Wetter DA,Davis MDP

    更新日期:2020-07-01 00:00:00

  • Pyostomatitis vegetans.

    abstract::Pyostomatitis vegetans is a rare oral disorder often associated with gastrointestinal and/or cutaneous diseases and sometimes with other disorders. The association of pyostomatitis vegetans with inflammatory bowel disease, particularly ulcerative colitis, is well known and in most cases bowel disease precedes the onse...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章,评审


    authors: Hegarty AM,Barrett AW,Scully C

    更新日期:2004-01-01 00:00:00

  • First case of Rubinstein-Taybi syndrome with desquamation associated with a novel mutation in the bromodomain of the CREBBP gene.

    abstract::Rubinstein-Taybi syndrome (RSTS) is a rare congenital disorder, mainly characterized by postnatal growth retardation, intellectual disability, and facial and limb abnormalities. Although not considered as characteristic manifestations, numerous cutaneous anomalies have also been reported in patients with RSTS while th...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Wang L,Deng Y,Zhou XL,Ma JJ,Li W

    更新日期:2019-07-01 00:00:00

  • Pure hair-nail ectodermal dysplasia maps to chromosome 12p11.1-q21.1 in a consanguineous Pakistani family.

    abstract::Ectodermal dysplasias (ED) are developmental disorders affecting tissues of ectodermal origin including hair, nail, teeth and sweat glands. To date, four different types of ectodermal dysplasias involving only hair and nails have been described. In an effort to understand the molecular basis of ED of hair and nails, a...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Naeem M,John P,Ali G,Ahmad W

    更新日期:2007-09-01 00:00:00

  • Induction of hair growth in alopecia totalis with diphencyprone sensitization.

    abstract::The therapeutic use of the induction of an allergic contact sensitivity to diphencyprone in alopecia areata has been studied. Fourteen subjects had alopecia totalis and four had extensive and long-standing alopecia areata. Topical diphencyprone was capable of inducing an allergic contact sensitivity in 16 subjects (89...

    journal_title:Clinical and experimental dermatology

    pub_type: 杂志文章


    authors: Monk B

    更新日期:1989-03-01 00:00:00